Distributed lag associations between respiratory illnesses and mortality with suspended particle concentration in Tula, a highly polluted industrial region in Central Mexico

  • Eva M. Melgar-Paniagua
  • Elizabeth Vega-Rangel
  • Luz M. Del Razo
  • Carlos A. Lucho-Constantino
  • Stephen J. Rothenberg
  • Andrea De Vizcaya-Ruiz
Original Article

Abstract

Purpose

We aimed to evaluate the association between changes in airborne particulate matter concentration (PM) with changes in cases of mortality, acute respiratory infections (ARI) and asthma over 2004–2008 in an industrialized and polluted region in central Mexico.

Methods

A generalized linear model with a Poisson distribution and a negative binomial analysis was used to evaluate the influence of PM and temperature on all-cause mortality (All-cause-M), cause-specific mortality (Cause-specific-M), ARI and asthma, using cubic spline functions and distributed lags of PM. Estimated changes in relative risk were calculated for an exposure corresponding to each increase of 10 μg/m3 in PM level.

Results

Associations between PM and mortality and morbidity were statistically most consistent for total suspended particulate (TSP) than for particulate matter <10 μM aerodynamic diameter (PM10). The greatest effects in mortality were observed with a 3-week lag, and effects were greater for Cause-specific-M. We also found a displacement effect up to 4-week lag for Cause-specific-M and TSP. The greatest effects in morbidity were observed at 0-week lag, yet they were statistically marginal and were greater for asthma. We found a displacement effect at 4–5–6-week lag for asthma and TSP. All associations of mortality and morbidity, expressed as change in relative risk, were greater with PM10; however, all of them were statistically marginal.

Conclusions

Increased respiratory morbidity and mortality is associated with weekly changes of PM air pollution in the region. A reduction in air pollutants from industrial sources would benefit life quality and health of the exposed population.

Keywords

Respiratory illnesses Mortality Air pollution Generalized linear model Distributed lag model Time-series 

References

  1. Abdo Arbex M, Conceição Martins L, Carvalho de Oliveira R et al (2007) Air pollution from biomass burning and asthma hospital admissions in a sugar cane plantation area in Brazil. J Epidemiol Community Health 61:395–400. doi:10.1136/jech.2005.044743 CrossRefGoogle Scholar
  2. Barraza-Villarreal A, Sunyer J, Hernandez-Cadena L, Escamilla-Nunez MC, Sienra-Monge JJ, Ramirez-Aguilar M et al (2008) Air pollution, airway inflammation, and lung function in a cohort study of Mexico City schoolchildren. Environ Health Perspect 116(6):832–838CrossRefGoogle Scholar
  3. Behndig AF, Mudway IS, Brown JL, Stenfors N, Helleday R, Duggan ST et al (2006) Airway antioxidant and inflammatory responses to diesel exhaust exposure in non-asthmatic humans. Eur Respir J 27:359–365CrossRefGoogle Scholar
  4. Beltrán I, Acevedo O, Alvarado P, Melgar-Paniagua EM, De Vizcaya-Ruiz A, Del Razo-Jimenez LM et al. (2008) Diagnósico de la calidad del Aire de la Región Tula–Tepeji, Hidalgo. Estado de Hidalgo, Gobierno del Estado de Hidalgo, Universidad Autónoma del Estado de Hidalgo, Universidad Politécnica de Pachuca, Centro de Investigación y de Estudios Avanzados del IPN, EnviroGlobe, S. A., SEMARNATGoogle Scholar
  5. Borja-Aburto VH, Loomis DP, Bangdiwala SI, Shy CM, Rascon-Pacheco RA (1997a) Ozone, suspended particulates, and daily mortality in Mexico City. Am J Epidemiol 145(3):258–268CrossRefGoogle Scholar
  6. Borja-Aburto VH, Munoz SR, Bustamante-Montes P (1997b) The case-control design in medical research. Rev Invest Clin 49(6):481–489Google Scholar
  7. Cakmak S, Dales RE, Vidal CB (2007) Air pollution and mortality in Chile: susceptibility among the elderly. Environ Health Perspect 115(4):524–527CrossRefGoogle Scholar
  8. Carbajal-Arroyo L, Miranda-Soberanis V, Medina-Ramón M, Rojas-Bracho L, Tzintzun G, Solís-Gutiérrez P, Méndez-Ramírez I, Hurtado-Díaz M, Schwartz J, Romieu I (2011) Effect of PM10 and O3 on infant mortality among residents in the Mexico City Metropolitan area: a case-crossover analysis, 1997–2005. J Epidemiol Community Health 65:715–721CrossRefGoogle Scholar
  9. CFE (2010) Estadisticas del Sector Eléctrico. http://www.sener.gob.mx/portal/industria_electrica_mexicana.html. Accessed on 2nd November 2011
  10. Chang G, Pan X, Xie X, Gao Y (2003) Time-series analysis on the relationship between air pollution and daily mortality in Beijing. Wei Sheng Yan Jiu 32(6):565–568Google Scholar
  11. Chatfield C (2004) The analysis of time series. An introduction, 6th edn. CRC, Chapman and Hall, LondonGoogle Scholar
  12. Cruz Mena E, Moreno Bolton R (1999) Asma bronquial. In: Aparato respiratorio, Fisiología y Clínica. 4ª Edición. Editorial Mediterráneo, Chile, pp 240–242Google Scholar
  13. Dear K, Ranmuthugala G, Kjelltröm T, Skinner C, Hanigan I (2005) Effects of temperature and ozone on daily mortality during the August 2003 heat wave in France. Arch Environ Occup Health 60(4):205–212CrossRefGoogle Scholar
  14. Dockery DW (2001) Epidemiologic evidence of cardiovascular effects of particulate air pollution. Environ Health Perspect 109(Suppl 4):483–486Google Scholar
  15. Dominici F, McDermott A, Zeger SL et al (2003) Airborne particulate matter and mortality: timescale effects in four US cities. Am J Epidemiol 157(12):1055–1065CrossRefGoogle Scholar
  16. GINA (2011) Global strategy for asthma management and prevention, global initiative for asthma. Available from: http://www.ginasthma.org/. Accessed on 2nd March 2012
  17. Goodman PG, Dockery DW, Clancy L (2004) Cause-Specific mortality and the extended effects of particulate pollution and temperature exposure. Environ Health Perspect 112(2):179–185CrossRefGoogle Scholar
  18. Hernandez-Cadena L, Tellez-Rojo MM, Sanin-Aguirre LH, Lacasana-Navarro M, Campos A, Romieu I (2000) Relationship between emergency consultations for respiratory diseases and air pollution in Juarez City, Chihuahua. Salud Publica Mex 42(4):288–297CrossRefGoogle Scholar
  19. Hernandez-Cadena L, Barraza-Villarreal A, Ramirez-Aguilar M, Moreno-Macias H, Miller P, Carbajal-Arroyo LA, Romieu I (2007) Infant morbidity caused by respiratory diseases and its relation with the air pollution in Juarez City, Chihuahua, Mexico. Salud Publica Mex 49(1):27–36CrossRefGoogle Scholar
  20. INEM (2005) Inventario Nacional de Emisiones de México 2005. Secretaría de Medio Ambiente y Recursos Naturales, Subsecretaría de Gestión para la Protección Ambiental, Dirección General de Gestión de la Calidad del Aire y RETC. December, 2011Google Scholar
  21. Kelsall JE, Samet JM, Zeger SL, Xu J (1997) Air pollution and mortality in Philadelphia, 1974–1988. Am J Epidemiol 146(9):750–762CrossRefGoogle Scholar
  22. Koenig JQ (1999) Air pollution and asthma. Department of Environmental Health, University of Washington, Seattle, Wash. 98195, USA. J Allergy Clin Immunol 104(4 Pt 1):717–722Google Scholar
  23. LaDou J (2005) Diagnóstico y tratamiento en medicina laboral y ambiental. 3ª. Edición. Editorial Manual Moderno, MéxicoGoogle Scholar
  24. Lippmann M, Ito K, Nadas A, Burnett RT (2000) Association of particulate matter components with daily mortality and morbidity in urban populations. Res Rep Health Eff Inst 95:5–72, discussion 73–82Google Scholar
  25. Loomis D, Castillejos M, Gold DR, McDonnell W, Borja-Aburto VH (1999) Air pollution and infant mortality in Mexico City. Epidemiology 10(2):118–123CrossRefGoogle Scholar
  26. McCullagh P, Nelder JA (1989) Generalized linear models. Chapman and Hall, LondonGoogle Scholar
  27. NOM-CCAM-002-ECOL-1993 (1993) Norma Oficial Mexicana que establece los métodos de medición para determinar la concentración de partículas suspendidas totales en el aire ambiente y el procedimiento para la calibración de los equipos de mediciónGoogle Scholar
  28. O’Neill MS, Loomis D, Borja-Aburto VH, Gold D, Hertz-Picciotto I, Castillejos M (2004) Do associations between airborne particles and daily mortality in Mexico City differ by measurement method, region, or modeling strategy? J Expo Anal Environ Epidemiol 14(6):429–439CrossRefGoogle Scholar
  29. PEMEX (2010) Anuario Estadístico 2010, Petróleos Mexicanos. http://www.ri.pemex.com/index.cfm?action=content&sectionID=134&catID=12202&media=pdf. Accessed on 2nd November 2011
  30. Rojas-Martinez R, Perez-Padilla R, Olaiz-Fernandez G et al (2007) Lung function growth in children with long-term exposure to air pollutants in Mexico City. Am J Respir Crit Care Med 176(4):377–384CrossRefGoogle Scholar
  31. Romieu I, Lugo MC, Velasco SR, Sanchez S, Meneses F, Hernandez M (1992) Air pollution and school absenteeism among children in Mexico City. Am J Epidemiol 136(12):1524–1531Google Scholar
  32. Romieu I, Meneses F, Ruiz S, Sienra JJ, Huerta J, Ruiz Velasco S, White MC, Etzel RA, Hernandez-Avila M (1995) Effects of urban air pollutants on emergency visits for childhood asthma in Mexico City. Am J Epidemiol 141(6):546–553Google Scholar
  33. Romieu I, Meneses F, Ruiz S, Sienra JJ, Huerta J, White MC, Etzel RA (1996) Effects of air pollution on the respiratory health of asthmatic children living in Mexico City. Am J Respir Crit Care Med 154(2 Pt 1):300–307Google Scholar
  34. Rosales-Castillo JA, Torres-Meza VM, Olaiz-Fernandez G, Borja-Aburto VH (2001) Acute effects of air pollution on health: evidence from epidemiological studies. Salud Publica Mex 43(6):544–555CrossRefGoogle Scholar
  35. Royston P, Sauerbrei W (2007) Multivariable modeling with cubic regression splines: a principled approach. Stata J 7(1):45–70Google Scholar
  36. Samoli E, Schwartz J, Wojtyniak B, Touloumi G, Spix C, Balducci F et al (2001) Investigating regional differences in short-term effects of air pollution on daily mortality in the APHEA project: a sensitivity analysis for controlling long-term trends and seasonality. Environ Health Perspect 109(4):349–353CrossRefGoogle Scholar
  37. Sánchez LR, Quadri GR, Martínez J, Pérez DR (1991) Evaluación de la calidad del aire en la Ciudad de México. Revista Internacional de Contaminación Ambiental 7(001):99–100Google Scholar
  38. Sasieni P (1994) Stata technical bulletin. STB22, Stata Corporation, New York. NovemberGoogle Scholar
  39. Schwartz J, Dockery DW (1992a) Increased mortality in Philadelphia associated with daily air pollution concentrations. Am Rev Respir Dis 145(3):600–604Google Scholar
  40. Schwartz J, Dockery DW (1992) Particulate air pollution and daily mortality in Steubenville, Ohio. Am J Epidemiol 135(1):12–19; discussion 20–15Google Scholar
  41. Schwartz J, Marcus A (1990) Mortality and air pollution in London: a time series analysis. Am J Epidemiol 131(1):185–194Google Scholar
  42. Secretaría de Salud (2008) Panorama Epidemiológico de la Región Tul-Tepeji, Hidalgo, Comisión para la Protección contra Riesgos Sanitarios del Estado de Hidalgo (COPRISEH), Subcomisión de Evidencia, Manejo de Riesgos y Trámites. Secretaría de Salud de HidalgoGoogle Scholar
  43. SEMARNAT (2006) Secretaria de Medio Ambiente y Recursos Naturales y Consejo Estatal de Ecología del Estado de Hidalgo. Inventario de emisiones de la Región Tula–Tepeji, 2002Google Scholar
  44. SEMARNAT (2009) Secretaria de Medio Ambiente y Recursos Naturales. Inventario de emisiones de la Región Tula–Tepej, 2005Google Scholar
  45. SINAVE (2006) Sistema Nacional de Vigilancia Epidemiológica. Manual de Procedimientos de la Notificación Semanal de Casos Nuevos. Secretaría de Salud, Primera Edición. pp 23–31Google Scholar
  46. SS (2008) Secretaria de Salud. Manual metodológico de camino a la excelencia 2008–2012Google Scholar
  47. Sunyer J, Schwartz J, Tobias A, Macfarlane D, Garcia J, Anto JM (2000) Patients with chronic obstructive pulmonary disease are at increased risk of death associated with urban particle air pollution: a case-crossover analysis. Am J Epidemiol 151(1):50–56CrossRefGoogle Scholar
  48. Takizawa H (2004) Diesel exhaust particles and their effect on induced cytokine expression in human bronchial epithelial cells. Curr Opin Allergy Clin Immunol 4:355–359CrossRefGoogle Scholar
  49. USEPA (1990) United Stats environmental protection agency. Code of federal regulations 40, Part 50, appendix B, revised July 1990, USAGoogle Scholar
  50. Welty LJ, Zeger SL (2005) Are the acute effects of particulate matter on mortality in the national morbidity, mortality, and air pollution study the result of inadequate control for weather and season? A sensitivity analysis using flexible distributed lag models. Am J Epidemiol 162(1):80–88CrossRefGoogle Scholar
  51. Zanobetti A, Schwartz J (2009) The effect of fine and coarse particulate air pollution on mortality: a national analysis. Environ Health Perspect 117(6):898–903CrossRefGoogle Scholar
  52. Zanobetti A, Schwartz J, Samoli E, Gryparis A, Touloumi G, Peacock J et al (2003) The temporal pattern of respiratory and heart disease mortality in response to air pollution. Environ Health Perspect 111(9):1188–1193CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Eva M. Melgar-Paniagua
    • 1
  • Elizabeth Vega-Rangel
    • 2
  • Luz M. Del Razo
    • 1
  • Carlos A. Lucho-Constantino
    • 3
  • Stephen J. Rothenberg
    • 1
    • 4
  • Andrea De Vizcaya-Ruiz
    • 1
  1. 1.Departamento de ToxicologíaCentro de Investigación y de Estudios Avanzados del Instituto Politécnico NacionalMexico Mexico
  2. 2.Programas de InvestigaciónInstituto Mexicano del PetróleoMexicoMexico
  3. 3.Ingeniería en BiotecnologíaUniversidad Politécnica de PachucaHidalgoMexico
  4. 4.Centro de Investigaciones en Salud PoblacionalInstituto Nacional de Salud Pública, Universidad No. 655, Col. Santa María AhuacatitlánCuernavacaMexico

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