PM10 air pollution exposure during pregnancy and term low birth weight in Allegheny County, PA, 1994–2000
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Low birth weight has been associated with increased risks of mortality and/or morbidity in childhood and adulthood. Epidemiological studies suggest that maternal exposure to air pollution, especially particulate matter during pregnancy, is associated with an increased risk of delivering a low birth weight infant. The aim of this study is to explore the association between exposure to particulate matter (PM10) during pregnancy and term low birth weight (LBW: birth weight <2,500 g and gestation age ≥ 37 weeks).
Birth data from the Allegheny County Health Department, Pittsburgh, PA, USA and PM10 air data generated with inverse-distance interpolation by RAND’s Center for Population Health and Health Disparities, were obtained. The study population consisted of all term singleton live births (gestational age ≥ 37 weeks) born between January 1, 1994 to December 31, 2000. Infants with birth weight <2,500 g were classified as LBW. Logistic regression with robust variance estimation was performed to estimate the odds ratios of LBW per inter-quartile range increase in PM10.
The results showed that the odds ratios of term LBW per inter-quartile range increase in PM10 were 1.13 (95% CI: 1.02–1.25) during the first trimester and 1.10 (95% CI: 1.00–1.22) during the second trimester after adjustment for other important covariates, respectively.
The findings of the study support the hypothesis that exposure to PM10 is associated with increased levels of term LBW. Further studies are warranted to corroborate these findings.
KeywordsAir pollution PM10 Low birth weight Adverse pregnancy outcomes
This study was supported by CDC Environmental Public Health Tracking Program Grant (Grant #: RFA 05074).
Conflict of interest statement
The authors declare that they have no conflict of interest.
- Aguilera I, Guxens M, Garcia-Esteban R, Corbella T, Nieuwenhuijsen MJ, Foradada CM, Sunyer J (2009) Association between GIS-based exposure to urban air pollution during pregnancy and birth weight in the INMA Sabadell Cohort. Environ Health Perspect 117(8):1322–1327Google Scholar
- Anderson HR, Spix C, Medina S, Schouten JP, Castellsague J, Rossi G, Zmirou D, Touloumi G, Wojtyniak B, Ponka A et al (1997) Air pollution and daily admissions for chronic obstructive pulmonary disease in 6 European cities: results from the APHEA project. Eur Respir J 10(5):1064–1071CrossRefGoogle Scholar
- Barker DJ (2004) The developmental origins of adult disease. J Am Coll Nutr 23(6 Suppl):588S–595SGoogle Scholar
- Jedrychowski W, Bendkowska I, Flak E, Penar A, Jacek R, Kaim I, Spengler JD, Camann D, Perera FP (2004) Estimated risk for altered fetal growth resulting from exposure to fine particles during pregnancy: an epidemiologic prospective cohort study in Poland. Environ Health Perspect 112(14):1398–1402CrossRefGoogle Scholar
- Perera FP, Jedrychowski W, Rauh V, Whyatt RM (1999) Molecular epidemiologic research on the effects of environmental pollutants on the fetus. Environ Health Perspect 107(Suppl 3):451–460Google Scholar
- Perera F, Hemminki K, Jedrychowski W, Whyatt R, Campbell U, Hsu Y, Santella R, Albertini R, O’Neill JP (2002) In utero DNA damage from environmental pollution is associated with somatic gene mutation in newborns. Cancer Epidemiol Biomarkers Prev 11(10 Pt 1):1134–1137Google Scholar
- Pope DP, Mishra V, Thompson L, Siddiqui AR, Rehfuess EA, Weber M, Bruce NG (2010) Risk of low birth weight and stillbirth associated with indoor air pollution from solid fuel use in developing countries. Epidemiol RevGoogle Scholar
- Schwartz J, Slater D, Larson TV, Pierson WE, Koenig JQ (1993) Particulate air pollution and hospital emergency room visits for asthma in Seattle. Am Rev Respir Dis 147(4):826–831Google Scholar
- USPIRG. U.S. Public Interest Research Group (2003) Danger in the air: unhealthy levels of air pollution in 2003. http://cdn.publicinterestnetwork.org/assets/Lphh5tAz7dtIhP8S2dTIdg/Danger_In_The_Air.pdf. Accessed on May 2, 2010
- Wang X, Ding H, Ryan L, Xu X (1997) Association between air pollution and low birth weight: a community-based study. Environ Health Perspect 105(5):514–520Google Scholar
- Zhang M, Song Y, Cai X (2007) A health-based assessment of particulate air pollution in urban areas of Beijing in 2000–2004. Sci Total Environ 376(1–3):100–108Google Scholar