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Persulphate challenge in female hairdressers with nasal hyperreactivity suggests immune cell, but no IgE reaction

  • Kerstin Kronholm DiabEmail author
  • Lennart Truedsson
  • Maria Albin
  • Jørn Nielsen
Original Article

Abstract

Purpose

The aim of this study was to examine the effects of persulphate on the nasal mucosa and on the immune cells in hairdressers suffering from bleaching powder associated rhinitis (BAR) versus subjects with rhinitis not previously exposed to bleaching powder.

Methods

Fifteen hairdressers (S) with BAR, 14 without symptoms (WS) and 12 atopics (A) with rhinitis but without exposure to bleaching powder were studied. Each performed a nasal challenge with persulphates. Effect parameters were symptom score, acoustic rhinometry, albumin in nasal lavage, subpopulations of lymphocytes in blood and specific serum antibodies.

Results

The S group had a post-challenge increase in nasal symptoms and nasal lavage albumin. The A group reacted to a lesser intent. The S and A groups showed an increase in Th1 cells. An HLA class II cell expression was noticed in both groups of hairdressers. No evidence of a type 1 reaction (immediate type) to persulphate was noticed.

Conclusions

Persulphate challenge affects hairdressers with BAR, but also atopics. The reaction may be driven by a Th1 cell activation.

Keywords

Bleaching powder Hairdressers IgE Nasal challenge Persulphate Rhinitis 

Notes

Acknowledgments

We thank I. Bensryd RN, P. Aprea BT and E. Assarsson RN for assistance with the challenges; B. Björk BT, G. Johannesson Med. Lic., K. Paulsson BT, A. Andreasson BT and S. Jönsson BT for laboratory analysis and Anna Axmon, associate professor, for statistical assistance. Financial support was obtained from the Swedish Council for Working Life and Social Research (No. 2001-0217).

References

  1. Aalto-Korte K, Mäkinen-Kiljunen S (2003) Specific immunoglobulin E in patients with immediate persulfate hypersensitivity. Contact Dermatitis 49:22–25. doi: 10.1111/j.0105-1873.2003.00134.x PubMedCrossRefGoogle Scholar
  2. Aas K, Belin L (1973) Standardization of diagnostic work in allergy. Int Arch Allergy 45:57–60PubMedGoogle Scholar
  3. Albin M, Rylander L, Mikoczy Z, Lillienberg L, Dahlman Höglund A, Brisman J et al (2002) The incidence of asthma in female Swedish hairdressers. Occup Environ Med 59:119–123. doi: 10.1136/oem.59.2.119 PubMedCrossRefGoogle Scholar
  4. Andersson M, Kogerer BV, Andersson P, Pipkorn U (1987) Allergen-induced nasal hyperreactivity appears unrelated to the size of the nasal and dermal immediate allergic reaction. Allergy 42:631–637. doi: 10.1111/j.1398-9995.1987.tb00395.x PubMedCrossRefGoogle Scholar
  5. Banauch GI, Dhala A, Prezant DJ (2005) Pulmonary disease in rescue workers at the World Trade Center site. Curr Opin Pulm Med 11(2):160–168. doi: 10.1097/01.mcp.0000151716.96241.0a PubMedCrossRefGoogle Scholar
  6. Brisman J, Albin M, Rylander L, Mikoczy Z, Lillienberg L, Höglund AD et al (2003) The incidence of respiratory symptoms in female Swedish hairdressers. Am J Ind Med 44(6):673–678. doi: 10.1002/ajim.10293 PubMedCrossRefGoogle Scholar
  7. Hilberg O, Pedersen OF (2000) Acoustic rhinometry: recommendations for technical specifications and standard operating procedures. Rhinol Suppl 16:3–17PubMedGoogle Scholar
  8. Hollund BE, Moen BE, Egeland GM, Florvaag E (2002) Occupational exposure to hairdressing chemicals and immunoglobulin E synthesis. Scand J Work Environ Health 28:264–269PubMedGoogle Scholar
  9. Hytönen M, Leino T, Sala E, Kanerva L, Tupasela O, Malmberg H (1997) Nasal provocation test in the diagnosis of hairdressers’ occupational rhinitis. Acta Otolaryngol Suppl 529:133–136. doi: 10.3109/00016489709124104 PubMedCrossRefGoogle Scholar
  10. Johannesson G, Rosqvist S, Lindh CH, Welinder H, Jönsson BAG (2001) Serum albumins are the major site for in vivo formation of hapten-carrier protein adducts in plasma from humans and guinea pigs exposed to Type-1 allergy inducing hexahydrophthalic anhydride. Clin Exp Allergy 31(7):1021–1030. doi: 10.1046/j.1365-2222.2001.01109.x PubMedCrossRefGoogle Scholar
  11. Jung T, Schauer U, Heusser C, Neumann C, Rieger C (1993) Detection of intracellular cytokines by flow cytometry. J Immunol Methods 159:197–207. doi: 10.1016/0022-1759(93)90158-4 PubMedCrossRefGoogle Scholar
  12. Källström E, Roscher I, Andreasson A, Bäck O, van Hage-Hamsten M (2002) Decreased frequency of intracellular IFN-γ producing T cells in whole blood preparations from patients with atopic dermatitis. Exp Dermatol 11:556–563. doi: 10.1034/j.1600-0625.2002.110608.x PubMedCrossRefGoogle Scholar
  13. Leino T, Tammilehto L, Luukkonen R, Nordman H (1997) Self reported respiratory symptoms and diseases among hairdressers. Occup Environ Med 54(7):452–455PubMedCrossRefGoogle Scholar
  14. Leino T, Tammilehto L, Hytonen M, Sala E, Pakkulainen H, Kanerva L (1998) Occupational skin and respiratory diseases among hairdressers. Scand J Work Environ Health 24(5):398–406PubMedGoogle Scholar
  15. Leroyer C, Malo JL, Girard D, Dufour JG, Gautrin D (1999) Chronic rhinitis in workers at risk of reactive airways dysfunction syndrome due to exposure to chlorine. Occup Environ Med 56:334–338PubMedCrossRefGoogle Scholar
  16. Macchioni P, Kotopulos C, Talini D, De Santis M, Masino E, Paggiaro PL (1999) Asthma in hairdressers: a report of 5 cases. Med Lav 90:776–785PubMedGoogle Scholar
  17. Malm L, Wihl JÅ, Lamm CJ, Lindqvist N (1981) Reduction of metacholine-induced nasal secretion by treatment with a new topical steroid in perennial non-allergic rhinitis. Allergy 36:209–214. doi: 10.1111/j.1398-9995.1981.tb01836.x PubMedCrossRefGoogle Scholar
  18. Melillo G, Bonini S, Cocco G, Davies RJ, de Monchy JG, Frolund L et al (1997) EAACI provocation tests with allergens. Report prepared by the European Academy of Allergology and Clinical Immunology Subcommittee on provocation tests with allergens. Allergy 52(Suppl 35):1–35. doi: 10.1111/j.1398-9995.1997.tb02538.x PubMedGoogle Scholar
  19. Moscato G, Pignatti P, Yacoub MR, Romano C, Spezia S, Perfetti L (2005) Occupational asthma and occupational rhinitis in hairdressers. Chest 128:3590–3598. doi: 10.1378/chest.128.5.3590 PubMedCrossRefGoogle Scholar
  20. Mũnoz X, Cruz MJ, Orriols R, Bravo C, Espuga M, Morell F (2003) Occupational asthma due to persulfate salts. Chest 123:2124–2129. doi: 10.1378/chest.123.6.2124 PubMedCrossRefGoogle Scholar
  21. Mũnoz X, Cruz MJ, Orriols R, Torres F, Espuga M, Morell F (2004) Validation of specific inhalation challenge for diagnosis of occupational asthma due to persulphate salts. Occup Environ Med 61:861–866. doi: 10.1136/oem.2004.013177 PubMedCrossRefGoogle Scholar
  22. Pang S, Fiume MZ (2001) Final report of the safety assessment of ammonium, potassium and sodium persulfate. Int J Toxicol 20(Suppl 3):7–21. doi: 10.1080/10915810152630710 PubMedGoogle Scholar
  23. Parra FM, Igea JM, Quirce S, Ferrando MC, Martin JA, Losada E (1992) Occupational asthma in a hairdresser caused by persulphate salts. Allergy 47:656–660. doi: 10.1111/j.1398-9995.1992.tb02391.x PubMedCrossRefGoogle Scholar
  24. Picker LJ, Singh MK, Zdraveski Z, Treer JR, Waldrop SL, Bergstresser PR et al (1995) Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry. Blood 86:1408–1419PubMedGoogle Scholar
  25. Rom WN (1992) Environmental and occupational medicine, 2nd edn. Little, Brown and Company, BostonGoogle Scholar
  26. Syk I, Andreasson A, Truedsson L, Brunkwall J, Risberg B (1999) Postoperative downregulation of MHC class II antigen on monocytes does not differ between open and endovascular repair of aortic aneurysms. Eur J Surg 165:1035–1042. doi: 10.1080/110241599750007856 PubMedCrossRefGoogle Scholar
  27. van Loveren H, Steerenberg AP, Garssen J, van Bree L (1996) Interaction of environmental chemicals with respiratory sensitization. Toxicol Lett 86:163–167. doi: 10.1016/0378-4274(96)03686-7 PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Kerstin Kronholm Diab
    • 1
    Email author
  • Lennart Truedsson
    • 2
  • Maria Albin
    • 1
  • Jørn Nielsen
    • 1
  1. 1.Department of Occupational and Environmental MedicineUniversity HospitalLundSweden
  2. 2.Department of Clinical Microbiology and ImmunologyUniversity HospitalLundSweden

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