Variation in the risk for liver and gallbladder cancers in socioeconomic and occupational groups in Sweden with etiological implications

Original Article

DOI: 10.1007/s00420-005-0015-1

Cite this article as:
Ji, J. & Hemminki, K. Int Arch Occup Environ Health (2005) 78: 641. doi:10.1007/s00420-005-0015-1

Abstract

Objectives: To examine the associations between socioeconomic/occupational factors and liver cancer at various anatomic sites (including primary liver, gallbladder and other cancers). Methods: We carried out a follow-up study on the economically active Swedish population, based on the Swedish Family-Cancer Database. Standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) were calculated in different social classes and occupations. Results: For primary liver cancer, farmers were at a decreased risk; increased risks were observed for male sales agents, journalists, seamen, waiters, cooks and female beverage manufacture workers. Similar patterns were observed for gallbladder cancer; workers employed as journalists, sales agents, cooks and stewards, and public safety workers showed increased risk. Only male transport workers showed increased risk of cancers in other parts. Conclusions: Occupations with high consumption of alcohol and/or high prevalence of smoking associated with a risk of liver and gallbladder cancers. The present study suggests that the effects of socioeconomic factors on liver cancer of different subsites are similar; alcohol drinking is a risk factor of gallbladder cancer because of the covariation of primary liver and gallbladder cancers in occupational groups.

Keywords

Liver cancer Primary gall bladder cancer Occupational exposures Follow-up study 

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  1. 1.Department of Bioscience at NovumKarolinska InstitutetHuddingeSweden
  2. 2.Division of Molecular Genetic EpidemiologyGerman Cancer Research Center (DKFZ)HeidelbergGermany

Personalised recommendations