Non-sensitising air pollution at workplaces and adult onset asthma
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The aim of this study was to elucidate further whether occupational exposure to non-sensitising air pollution at workplaces increases the risk of adult onset asthma.
One hundred and twenty persons with asthma diagnosed by general practitioners, aged 20–65 years, were compared with 446 referents matched for age and gender and living in the same community as the cases. Information about occupation, exposure to specific allergens, smoking habits, dwellings and atopy was obtained from a postal questionnaire. The subjects' occupations were categorised as clean or polluted, based on the judgement of the referents on their respective occupations.
Three years or more of work in air-polluted workplaces resulted in an odds ratio of 1.7 (95% confidence interval 1.0–2.7). Stratification of the material on smoking habits, gender or atopy did not alter the results, nor did exclusion of subjects exposed to specific allergens of statistical significance in this material, e.g. flour dust. Smoking per se did not bring any risk of asthma. Working in buildings affected by dampness and mould brought a fourfold significant risk.
In this study occupational exposure to unspecific air pollution at workplaces was associated with an increased risk of adult-onset asthma.
KeywordsDust Building dampness Non-allergic asthma Case–referent study Low-level RADS Exposure matrix
- Arbetsmarknadsstyrelsen Solna, Sweden (1983) Nordisk yrkesklassificering (in Swedish). Nordic classification of job titles, National Board of LabourGoogle Scholar
- Christiani D, Kern D (1993) Asthma risk and occupation as a respiratory therapist. Am Rev Respir 148:671–674Google Scholar
- Kipen H, Blume R, Hutt D (1994) Asthma experience in an occupational and environmental medicine clinic. Low-dose reactive airways dysfunction syndrome. J Med 36:1133–1137Google Scholar
- Larsson K, Ohlsen P, Larsson L, Malmberg P, Rydstrom PO, Ulriksen H (1993) High prevalence of asthma in cross country skiers. Br Med J 307:1326–1329Google Scholar
- Miyamoto T (1997) Epidemiology of pollution-induced airway disease in Japan. Allergy 52 [Suppl 38]:30–34Google Scholar
- Ng TP, Hong CH, Goh LG, Wong LM, Koh KT, Ling SL (1994) Risk of asthma associated with occupations in a community-based case-control study. Am J Ind Med 25:708–718Google Scholar
- Olin A-C (2002) Exhaled nitric oxide in epidemiological and experimental studies. Thesis. The Sahlgrenska Academy, Gothenburg University, SwedenGoogle Scholar
- Rothman K, Greenland S (1998) Modern epidemiology. Lippincott-Raven, Philadelphia, PennsylvaniaGoogle Scholar
- Statistics and Epidemiology Research Corporation (1995) Egret package for multiple logistic regression, version 0.26.01. Seattle, USAGoogle Scholar
- Tarlo S (2000) Workplace respiratory irritants and asthma. Occup Med: State of the Art Reviews 15:471–483Google Scholar