Metabolic disturbances in male workers with rotating three-shift work. Results of the WOLF study
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The aim of the present study was to investigate the relationship between important metabolic risk factors for coronary heart disease (CHD) and type 2 diabetes in shift workers and day workers.
Cross-sectional data from a sub-population in the WOLF study consisting of 665 day workers and 659 three-shift workers in two plants were analysed.
A higher proportion of shift workers than day workers had high triglyceride levels (≥1.7 mmol/l), low levels of HDL-cholesterol (<0.9 mmol/l) and abdominal obesity (waist/hip ratio>0.9). The risk of low HDL-cholesterol was doubled in shift workers, (odds ratio (OR): 2.02, 95% confidence interval (95% CI): 1.24–3.28) after being adjusted for age, socio-economic factors, physical activity, current smoking, social support and job strain. High levels of triglycerides were also significantly associated with shift work (OR: 1.40, 95% CI: 1.08–1.83). The OR for abdominal obesity was 1.19, (95% CI: 0.92–1.56). The prevalence of hyperglycaemia (serum glucose ≥7.0 mmol/l) was similar in day and shift workers. No significant interaction was seen between shift work and abdominal obesity with regard to the associations with triglycerides and HDL-cholesterol.
We found a significant association between shift work and lipid disturbances (i.e. low HDL-cholesterol and high triglyceride levels). We did not find any association with hyperglycaemia.
KeywordsShift work Metabolic factors Abdominal obesity job strain
This study was supported by a grant from the Swedish Work Environmental Fund. The authors would like to express their gratitude to the participants and the supportive management of the MoDo company. The collaborative part of this research was supported by the European Science Foundation Scientific Program 'Social Variations in Health Expectancy in Europe.'
- Boden G, Ruiz J, Urbain J-L, Xinhua C (1996) Evidence for a circadian rhythm of insulin. Am J Phys: E246–E252Google Scholar
- Costa G, Betta A, Uber D, Alexopoulos C (1990) Estimate of coronary risk in a group of Italian shiftworkers. In: Costa G, Cesana G, Kogi K, Wedderburn A (eds) Shiftwork: health, sleep and performance. Lang, Frankfurt am Main, pp 363–369Google Scholar
- De Backer G, Kornitzer M, Dramaix M, Peeters H, Kittel F (1987) Irregular working hours and lipid levels in men. In: G Schling, H Mörl (eds) Expanding horizons in atherosclerosis research. Springer, Berlin, pp 217–224Google Scholar
- Hampton SM, Morgan LM, Lawrance N, Anastasiadou T, Norris F, Deacon S, Ribeiro D, Arendt J (1996) Postprandial hormone and metabolic responses in simulated shiftwork. J Endocrinol 151:257–267Google Scholar
- Lasfargues G, Vol S, Cacès E, Le Clésiau H, Lecomte P, Tichet J (1996) Relations among nightwork, dietary habits, biological measures, and health status. Int J Behav Med 3:123–134Google Scholar
- Lennernäs MAC (1993) Nutrition and shiftwork. Thesis, Uppsala University, SwedenGoogle Scholar
- Lindahl B, Asplund K, Eliasson M, Evrin P-E (1996) Insulin resistance syndrome and fibrinolytic activity: the Northern Sweden MONICA study. Int J Epidemiol 25:1–9Google Scholar
- Mikuni E, Ohoshi T, Hayashi K, Miyamura K (1983) Glucose intolerance in an employed population. Tohoku J Exp Med 141 [Suppl]:251–256Google Scholar
- Nakamura K, Shimai S, Kikuchi S, Tominaga K, Takahashi H, Tanaka M, Nakano S, Motohashi Y, Nakadaira H, Yamamoto M (1997) Shiftwork and risk factors for coronary heart disease in Japanese blue-collar workers: serum lipids and anthropometric characteristics. Occup Med 47:142–146Google Scholar
- Niedhammer I, Lert F, Marne M-J (1996) Prevalence of overweight and weight gain in relation to night work in nurses' cohort. Int J Obes 20:625–633Google Scholar