Histochemistry and Cell Biology

, Volume 151, Issue 4, pp 283–289 | Cite as

Peroxisomes: new insights into protein sorting, dynamics, quality control, signalling and roles in health and disease

  • Joseph L. Costello
  • Einat Zalckvar
  • Stephan Kemp
  • Francesca di Cara
  • Peter K. Kim
  • Nicole Linka
  • Ida J. van der KleiEmail author
Meeting Report


The 6th Open European peroxisome meeting (OEPM) was held on the 26th and 27th of October (2018) in Groningen, the Netherlands. OEPM is a biannual meeting organized by a European peroxisome research group. Previous meetings were held in Leuven, BE (2006), Lunteren, NL (2010), Dijon, FR (2012), Neuss, GER (2014) and Vienna, AU (2016). Over 120 participants were registered from 14 European countries, as well as Israel, Canada, the USA and South Korea. A large number of European research groups participated, including established and younger groups, showing that peroxisome research is blooming in Europe. This will further expand with the EU Marie Curie Innovative training network PERICO (PERoxisome Interactions and COmmunication;; coordinated by Ida van der Klei), which recently started and aims to train the next generation of peroxisome researchers.

At OEPM young peroxisome researchers (PhD students, junior Post-docs) present their work to an...



  1. Beach A, Burstein MT, Richard VR et al (2012) Integration of peroxisomes into an endomembrane system that governs cellular aging. Front Physiol 3:283. CrossRefGoogle Scholar
  2. Bellu AR, Salomons FA, Kiel JA et al (2002) Removal of Pex3p is an important initial stage in selective peroxisome degradation in Hansenula polymorpha. J Biol Chem 277:42875–42880. CrossRefGoogle Scholar
  3. Bulow MH, Wingen C, Senyilmaz D et al (2018) Unbalanced lipolysis results in lipotoxicity and mitochondrial damage in peroxisome-deficient Pex19 mutants. Mol Biol Cell 29:396–407. CrossRefGoogle Scholar
  4. Cara FD, Bulow MH, Simmonds AJ et al (2018) Dysfunctional peroxisomes compromise gut structure and host defense by increased cell death and Tor-dependent autophagy. Mol Biol Cell 29:2766–2783. CrossRefGoogle Scholar
  5. Chen X, Devarajan S, Danda N, Williams C (2018) Insights into the Role of the Peroxisomal Ubiquitination Machinery in Pex13p Degradation in the Yeast Hansenula polymorpha. J Mol Biol 430:1545–1558. CrossRefGoogle Scholar
  6. Colasante C, Chen J, Ahlemeyer B, Baumgart-Vogt E (2015) Peroxisomes in cardiomyocytes and the peroxisome / peroxisome proliferator-activated receptor-loop. Thromb Haemost 113:452–463. CrossRefGoogle Scholar
  7. Costello JL, Castro IG, Hacker C et al (2017a) ACBD5 and VAPB mediate membrane associations between peroxisomes and the ER. J Cell Biol 216:331–342. CrossRefGoogle Scholar
  8. Costello JL, Castro IG, Schrader TA et al (2017b) Peroxisomal ACBD4 interacts with VAPB and promotes ER-peroxisome associations. Cell Cycle 16:1039–1045. CrossRefGoogle Scholar
  9. Di Cara F, Sheshachalam A, Braverman NE et al (2017) Peroxisome-Mediated Metabolism Is Required for Immune Response to Microbial Infection. Immunity 47:93–106 e107. CrossRefGoogle Scholar
  10. Dixit E, Boulant S, Zhang Y et al (2010) Peroxisomes are signaling platforms for antiviral innate immunity. Cell 141:668–681. CrossRefGoogle Scholar
  11. El Magraoui F, Brinkmeier R, Mastalski T et al (2019) The deubiquitination of the PTS1-import receptor Pex5p is required for peroxisomal matrix protein import. Biochim Biophys Acta Mol Cell Res 1866:199–213. CrossRefGoogle Scholar
  12. Fransen M, Nordgren M, Wang B et al (2013) Aging, age-related diseases and peroxisomes. Subcell Biochem 69:45–65. CrossRefGoogle Scholar
  13. Pedrosa AG, Francisco T, Bicho D et al (2018) Peroxisomal monoubiquitinated PEX5 interacts with the AAA ATPases PEX1 and PEX6 and is unfolded during its dislocation into the cytosol. J Biol Chem 293:11553–11563. CrossRefGoogle Scholar
  14. Sellin J, Wingen C, Gosejacob D et al (2018) Dietary rescue of lipotoxicity-induced mitochondrial damage in Peroxin19 mutants. PLoS Biol 16:e2004893. CrossRefGoogle Scholar
  15. Trompier D, Vejux A, Zarrouk A et al (2014) Brain peroxisomes Biochimie 98: 102–110. CrossRefGoogle Scholar
  16. Williams C, van der Klei IJ (2013) Pexophagy-linked degradation of the peroxisomal membrane protein Pex3p involves the ubiquitin-proteasome system. Biochem Biophys Res Commun 438:395–401. CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.BiosciencesUniversity of ExeterExeterUK
  2. 2.Department of Molecular GeneticsWeizmann Institute of ScienceRehovotIsrael
  3. 3.Amsterdam UMCAmsterdamThe Netherlands
  4. 4.Department of Microbiology and ImmunologyDalhousie UniversityHalifaxCanada
  5. 5.Hospital for Sick ChildrenUniversity of TorontoTorontoCanada
  6. 6.Heinrich-Heine-University DüsseldorfDüsseldorfGermany
  7. 7.University of GroningenGroningenThe Netherlands

Personalised recommendations