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A submicron emulsion of HU-211, a synthetic cannabinoid, reduces intraocular pressure in rabbits

  • N. Naveh
  • C. Weissman
  • S. Muchtar
  • S. Benita
  • R. Mechoulam
LABORATORY INVESTIGATION

Abstract 

Purpose: To study the ocular hypotensive effect of a nonpsychotropic cannabinoid, HU-211 (11-hydroxy-Δ8-tetra-hydrocannabinol, dimethylheptyl), an N-methyl-D-aspartate (NMDA) agonist, in normotensive rabbits. Methods: The cannabinoid HU-211, being lipophilic, was incorporated into a stable oil-in-water submicron sterile emulsion, consisting of 0.12% (w/w) HU-211. A single- dose, randomized and double-masked study was designed, using a Digilab 30R pneumotonometer to measure intraocular pressure (IOP) in normotensive rabbits. Results: Application of a single dose of HU-211 ophthalmic preparation resulted in an IOP reduction of 5.3 mmHg (24% of baseline), first evident at 1.5 h post application and persisting for over 6 h. A small but significant lowering of pressure (12.5% of baseline) occurred in the contralateral eyes of HU-211 treated rabbits, lasting for 4 h post treatment. Conclusion: Our work demonstrated that HU-211, incorporated into submicron emulsion, caused a 6-h-long reduction in IOP in the treated eye, with a lesser reduction in the contralateral untreated eye.

Keywords

NMDA Intraocular Pressure Hypotensive Effect Post Application Ophthalmic Preparation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • N. Naveh
    • 1
  • C. Weissman
    • 1
  • S. Muchtar
    • 2
  • S. Benita
    • 2
  • R. Mechoulam
    • 2
  1. 1.Glaucoma and Pharmacology Laboratory, Goldschleger Eye Research Institute, Sheba Medical Center, Tel Hashomer, 52621, Israel, Tel.: +972-3-6421902, Fax: +972-3-6421908IL
  2. 2.School of Pharmacy, The Hebrew University, Jerusalem, IsraelIL

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