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MHC expression in syngeneic and allogeneic retinal cell transplants in the rat

  • J. Larsson
  • Bengt Juliusson
  • Richard Holmdahl
  • Berndt Ehinger
SHORT COMMUNICATION

Abstract 

· Background: The major histocompatibility complexes, MHC class I and II, are found only sparsely or not at all in the retina. Since the eye is immunoprivileged, we decided to investigate how the MHC class I and II antigens were influenced by a retinal transplant and whether this could be correlated to rejection of the transplant. · Methods: Fetal neural retinas of Sprague-Dawley (SD) rats were implanted in the subretinal space of adult Lewis and SD rats. After 5 weeks the retinas and the transplants were evaluated with antibodies against MHC class I and II antigens as well as microglia. · Results: In the syngeneic transplants no upregulation of MHC class I antigen was seen and no MHC class II-positive cells could be detected. In the allogeneic transplants, on the other hand, there was marked upregulation of MHC class I antigen. Numerous MHC class II antigen-positive cells were seen in the subretinal transplant but also in the host retina. · Conclusion: Allogeneic retinal transplants seem to grow and thrive just as well as syngeneic transplants, but in the former there is considerable upregulation of MHC expression. Our interpretation of these results is that the allogeneic transplants are recognized as non-self, but that there is also something that modifies this reaction of the immune system at this level, preventing the rejection that would normally ensue.

Keywords

Immune System Retina Major Histocompatibility Complex Cell Transplant Retinal Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • J. Larsson
    • 1
  • Bengt Juliusson
    • 1
  • Richard Holmdahl
    • 2
  • Berndt Ehinger
    • 1
  1. 1.Department of Ophthalmology, Lund University Hospital, S-221 85 Lund, Sweden, Tel. +46 46 17 20 74, Fax +46 46 211 50 74, e-mail Jorgen.Larsson@oft.lu.seSE
  2. 2.Department of Medical Inflammation Research, Lund University Hospital, Lund, SwedenSE

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