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Pupillographic sleepiness testing in hypersomniacs and normals

  • H. Wilhelm
  • Holger Lüdtke
  • Barbara Wilhelm
CLINICAL INVESTIGATION

Abstract 

· Background: Pupillary oscillations in darkness are considered to be a sign of sleepiness. The purpose of this pilot study was to ascertain whether pupillary oscillations were more pronounced in patients with hypersomnia than in normals. · Methods: Seven patients (four with sleep apnea syndrome, three with narcolepsy) and seven age-matched controls underwent pupillography for 11 min in complete darkness. The changes in pupil size were analyzed mathematically to determine quantitatively the amount of pupillary instability. · Results: Hypersomniacs had much higher amounts of pupillary oscillations in darkness than normals. The differences were significant. Baseline pupil size did not differ significantly between the two groups. · Conclusion: This study showed that a pupillographic sleepiness test based on the evaluation of spontaneous pupillary changes in darkness is applicable in hypersomniacs and may facilitate therapy control, i.e. diagnostic grading by measuring daytime sleepiness objectively.

Keywords

Pilot Study Sleep Apnea Daytime Sleepiness Narcolepsy Pupil Size 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • H. Wilhelm
    • 1
  • Holger Lüdtke
    • 1
  • Barbara Wilhelm
    • 1
  1. 1.Department of Pathophysiology of Vision and Neuro-ophthalmology, University Eye Clinic, Schleichstrasse 12, D-72076 Tübingen, Germany, Tel. +49-7071-2984786, Fax +49-7071-295361, e-mail helmut.wilhelm@uni-tuebingen.deDE

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