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Transforming growth factor-β2 levels in aqueous humor of glaucomatous eyes

  • Masaru Inatani
  • Hidenobu Tanihara
  • Hideto Katsuta
  • Megumi Honjo
  • Noriaki Kido
  • Yoshihito Honda
Clinical Investigation

Abstract.

Purpose: To determine whether clinical characteristics are correlated with increased levels of transforming growth factor-β2 (TGF-β2) in aqueous humor in glaucomatous eyes. Methods: Aqueous humor samples were collected from 91 glaucomatous eyes. Included were samples from primary open-angle glaucoma (POAG) in 40 eyes, (pseudo)exfoliation syndrome (EXS) in 18 eyes, primary angle-closure glaucoma (PACG) in 26 eyes and uveitis-related secondary glaucoma (SG) in 7 eyes. TGF-β2 in aqueous humor was assessed with a specific-capture ELISA. Results: The mean concentration (± standard error) of mature (biologically active) TGF-β2 in the aqueous humor of eyes with POAG was 293.6±33.6 pg/ml, significantly higher than that in eyes with PACG, EXS and SG: 147.5±28.1, 135.8±30.2 and 41.0±10.7 pg/ml, respectively (P=0.0006, P=0.0010 and P=0.0003; analysis of variance). The mean concentration (± standard error) of total TGF-β2 in the aqueous humor of eyes with POAG was 1647.6±124.5 pg/ml, not significantly different from that in eyes with PACG, EXS and SG: 1482.9±148.2, 1442.7±187.8 and 1929.0±367.6 pg/ml, respectively. A multivariate analysis using logistic regression showed significant correlations between mature TGF-β2 concentration and history of cataract surgery (P=0.0225) and the use of carbonic anhydrase inhibitors (P=0.0143). Conclusions: Our results indicate that increased levels of TGF-β2 may play an important role in the pathogenesis of POAG.

Keywords

Logistic Regression Glaucoma Cataract Aqueous Humor Carbonic Anhydrase Inhibitor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Masaru Inatani
    • 1
  • Hidenobu Tanihara
    • 2
  • Hideto Katsuta
    • 1
  • Megumi Honjo
    • 1
  • Noriaki Kido
    • 1
  • Yoshihito Honda
    • 1
  1. 1.Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
  2. 2.Department of Ophthalmology, Tenri Hospital, Mishima-cho 200, Tenri, Nara 632-8552, Japan

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