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The association of myopia progression with the morphological changes of optic disc and β-peripapillary atrophy in primary school students

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Abstract

Purpose

To study the association of myopia progression with the morphological changes of optic disc and β-peripapillary atrophy (β-PPA) in 8–11 years old primary school students.

Methods

This study was a prospective, school-based investigation. This study included 610 children (1008 eyes) who were continuously observed and had data available from 2016 to 2017 in the Sanhe Cohort Study of the Risk Factors for Myopia (SCSRFM). The children underwent a comprehensive eye examination including measurement of visual acuity, autorefractometry, and posterior segment of the eye. β-PPA regions and optic disc ovality index were identified and measured on the fundus photographs.

Results

The prevalence of myopia was 72.62% (732/1008) in 2016. In myopic children, the prevalence of the vertical β-PPA, the horizontal β-PPA, and the oval optic disc were 75.68% (554/732), 75.96% (556/732) and, 11.61% (85/732) respectively. From 2016 to 2017, with the progression of vertical β-PPA, horizontal β-PPA, area of β-PPA, and optic disc ovality index, the myopic diopter and the axial length (AL) were increased. The progression of horizontal β-PPA was significantly correlated with the progression of myopic diopter and AL (all p < 0.05). The analysis on the distribution of progression rate of parameters in different groups found that the progression rate of horizontal β-PPA, area of β-PPA, and optic disc ovality index increased with the increase of the progression of diopter and AL. The progression of horizontal β-PPA, area of β-PPA, optic disc ovality index, and diopter in girls were greater than that in boys, and the progression of optic disc ovality index and diopter had a statistical significance (all p < 0.05).

Conclusions

The 1-year follow-up study of the third-grade primary school students showed that with the progression of myopia and the growth of AL, β-PPA and optic disc ovality index also changed. There was a positive correlation between the change of β-PPA and optic disc ovality index and the progression of myopia diopter and AL.

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Funding

The Beijing Hospitals Authority provided financial support in the form of Beijing Hospitals Authority Clinical medicine Development of special funding support (XMLX202133) funding; the work committee for women and children of China State department provided financial support in the form of Fund of work committee for women and children of China State department (2014108) funding; and the Beijing Institute of Ophthalmology provided financial support in the form of Beijing Institute of Ophthalmology Key Research Program Funding Projects (2019009) funding.

The sponsors had no role in the design or conduct of this research.

Author information

Authors and Affiliations

  1. Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital of Capital Medical University, Beijing, 100005, China

    Jing-Shang Zhang, Jin-Da Wang, Kai Cao, Si-Meng Hou, Mayinuer Yusufu, Meng Li, Ying-Yan Mao, Xiu-Li Sun, Shu-Ying Chen, Zhen-Yu Liu, Zi-Bing Jin, Ning-Li Wang & Xiu-Hua Wan

  2. Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Beijing Tongren Hospital of Capital Medical University, Beijing, 100005, China

    Jing Li, Ying Xiong & Kai-Jie Wang

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  1. Jing-Shang Zhang
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  2. Jing Li
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Contributions

Conception and design (XHW, JSZ, JL, JDW); acquisition of data (JSZ, JL, JDW, YX, SMH, XLS, SYC, ZYL); analysis and interpretation of data (JSZ, KC); drafting the article or revising it (SJZ, MY); final approval of the version (ZBJ, NLW, XHW).

Corresponding author

Correspondence to Xiu-Hua Wan.

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Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the Institutional Review Board of Beijing Tongren Hospital (QN20150228), Capital Medical University and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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The authors declare no competing interests.

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Zhang, JS., Li, J., Wang, JD. et al. The association of myopia progression with the morphological changes of optic disc and β-peripapillary atrophy in primary school students. Graefes Arch Clin Exp Ophthalmol 260, 677–687 (2022). https://doi.org/10.1007/s00417-021-05331-9

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  • DOI: https://doi.org/10.1007/s00417-021-05331-9

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