Spontaneous regression of congenital corneal opacity

  • Sooyeon Choe
  • Chang Ho Yoon
  • Mee Kum Kim
  • Joon Young Hyon
  • Young Suk Yu
  • Joo Youn OhEmail author



To determine the incidence of spontaneous regression of congenital corneal opacity (CCO) and identify clinical factors associated with the regression.


Medical records and anterior segment photographs were reviewed of 57 eyes in 35 patients with CCO that were not related to congenital glaucoma, tumors, infection, trauma, or metabolic disorders and were followed up without corneal transplantation for longer than one year at Seoul National University Hospital. Spontaneous regression of corneal opacity was defined as a decrease in corneal opacity significant enough for visual axis clearance. Data on demographics, systemic, and ocular characteristics were collected and compared between patients who had spontaneous regression of CCO and those who did not.


Spontaneous regression of corneal opacity developed in 32 eyes (22 patients, 56.1%) out of 57 CCO eyes (35 patients) at the mean 8.2 ± 5.4 months of age (the median 6.7 months). Absence of combined ocular anomalies such as iris anomaly, lens opacity, and peripheral corneal vascularization was significantly associated with the regression of opacity.


Corneal opacity can spontaneously regress in 56.1% of eyes with CCO during the first year of life. Careful follow-up with amblyopia management can be one of treatment options for CCO.


Congenital corneal opacity Corneal vascularization Neonatal corneal opacity Regression Spontaneous regression 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the Institutional Review Board of Seoul National University Hospital (IRB No. H-1810-029-977) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from guardians of all individual participants included in the study.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of OphthalmologySeoul National University HospitalSeoulKorea
  2. 2.Department of OphthalmologySeoul National University College of MedicineSeoulKorea
  3. 3.Department of OphthalmologySeoul National University Bundang HospitalSeongnamKorea

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