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Full-field electroretinogram behavior in Vogt-Koyanagi-Harada disease: a 24-month longitudinal study in patients from acute onset evaluated with multimodal analysis

  • Viviane Mayumi SakataEmail author
  • Marcelo Mendes Lavezzo
  • Felipe T. da Silva
  • Ever Ernesto Caso Rodriguez
  • Celso Morita
  • Smairah Frutuoso Abdallah
  • Maria Kiyoko Oyamada
  • Carlos Eduardo Hirata
  • Joyce Hisae Yamamoto
Inflammatory Disorders

Abstract

Purpose

To prospectively evaluate the dynamic changes of the full-field electroretinogram (ff-ERG) and its association with inflammatory signs in patients with Vogt-Koyanagi-Harada disease (VKHD) followed up after acute onset.

Methods

Twelve acute VKHD patients, who were followed up for at least 24 months, were enrolled at a tertiary center from June 2011 to January 2017. Treatment consisted of intravenous methylprednisolone followed by 1 mg/kg/day of oral prednisone with a slow tapering associated with late non-steroidal immunosuppressive therapy in previously defined cases. Inflammation was systematically evaluated with clinical and posterior segment imaging (PSI) exams (fluorescein angiography, FA, indocyanine green angiography, ICGA, enhanced depth imaging optical coherence tomography, EDI-OCT). A ff-ERG was performed upon enrollment as well as at predefined intervals. Scotopic ff-ERG parameters changes between the 12th and 24th months defined the ERG-stable or ERG-worsening groups. “Flare” was defined as an appearance or worsening of inflammatory signs (after the initial 6 months following disease onset) under the predefined treatment protocol.

Results

ff-ERG parameters initially improved in all eyes; in the evaluation between the 12th and 24th months, ff-ERG results were stable in 17 eyes (71 %) and worsened in 7 eyes (29 %). Subnormal ff-ERG results were observed in 15 eyes (62 %) at the 24th month. On the other hand, the flare was observed in 8 eyes (33 %) as cells in the anterior chamber and in 24 eyes (100 %) as any PSI inflammatory sign. The ERG-worsening group presented thicker subfoveal choroid at the first month (p = 0.001) and fluctuations in choroidal thickness more often during follow-up when compared to the ERG-stable group (p = 0.02).

Conclusions

Scotopic ff-ERG parameters worsened between the 12th and 24th months in a quarter of the patients. Subclinical inflammation detected as an increase in CT seems to be related to worsening in visual function measured with ffERG.

Keywords

Vogt-Koyanagi-Harada Subclinical inflammation Indocyanine green angiography Electroretinogram Corticosteroid 

Notes

Acknowledgments

The authors thank Rogério Ruscitto Prado, PhD in Statistics, Department of Public Health and Preventive Medicine, University of São Paulo School of Medicine, São Paulo, Brazil, for his assistance in statistical analysis; Dr. Emmett Cunningham, Department of Ophthalmology, California Pacific Medical Center, San Francisco, California, USA, Department of Ophthalmology, Stanford University School of Medicine, Stanford, California, USA, Francis I. Proctor Foundation; UCSF School of Medicine, San Francisco, California, USA, for his critical reading and suggestions on the manuscript. Part of this paper was presented as an oral presentation at American Research in Vision and Ophthalmology (ARVO) 2015 in Denver, Colorado. No financial disclosure.

Authors’ Contributions

All authors contributed to the manuscript as follows:

VMS, MML, FTS, CM, EECR, SFA, CEH, MKO, JHY: conception, design, analysis, and interpretation of data.

VMS, JHY: drafting the paper.

CEH, MKO, JHY: revising paper critically for important intellectual content.

VMS, MML, FTS, CM, EECR, SFA, CEH, MKO, JHY: final approval of version sent out for publishing.

All authors read and approved the final manuscript.

Funding

This study was funded by the São Paulo Research Foundation (FAPESP) through grants 2011/19194-4 (VMS); 2013/07462-0 (SFA); 2014/01222-2 (SFA); 2011/50936-7, São Paulo Research Foundation (FAPESP). The other authors received no funding or support relative to this study.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in this study were in accordance with the ethical standards of the institutional research committee (0496/11) and the 1964 Helsinki declaration and its later amendments.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Viviane Mayumi Sakata
    • 1
    • 2
    Email author
  • Marcelo Mendes Lavezzo
    • 1
  • Felipe T. da Silva
    • 3
  • Ever Ernesto Caso Rodriguez
    • 1
  • Celso Morita
    • 1
  • Smairah Frutuoso Abdallah
    • 1
  • Maria Kiyoko Oyamada
    • 1
  • Carlos Eduardo Hirata
    • 1
  • Joyce Hisae Yamamoto
    • 1
  1. 1.Department of Ophthalmology, Faculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil
  2. 2.Department of Ophthalmology, Faculdade de MedicinaUniversidade Federal do ParanáCuritibaBrazil
  3. 3.Clinica GasparLagesBrazil

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