Clinical and etiologic characteristics of de novo uveitis in patients aged 60 years and above: experience of a French tertiary center
To describe the characteristics of de novo uveitis in patients ≥ 60 years old.
Retrospective review of patients with uveitis followed in our tertiary center over a 14-year period. Patients aged 60–70 years and patients aged > 70 years were compared.
A total of 283/1044 (27.1%) patients with uveitis were ≥ 60 years of age. Idiopathic uveitis (36.1%) and sarcoidosis (31.5%) were the most frequent etiologies. Sarcoidosis was significantly more frequent (31.5% vs. 13.7%, p < 0.0001) after the age of 60 years. Intraocular lymphoma (5.0% vs. 1.1%) and herpes virus infection (5.0% vs. 0.9%) were also more common in this age group, unlike HLA B27-related uveitis and spondyloarthritis (4.6% vs. 14.9%). Pure ophthalmologic entities: birdshot retinochoroidopathy (2.8%) or Fuchs uveitis (0.4%), were rare in patients ≥ 60 years of age and Posner Scholssman, Pars planitis, White dots syndrome, Behçet’s disease, and Multiple Sclerosis were never reported. In patients > 70 years old, idiopathic uveitis (41.1% vs. 31.7%) and presumed sarcoidosis (56.5% vs. 25.6%) were more frequent than in the 60–70-year age group.
In our center, sarcoidosis is the leading cause of non-idiopathic uveitis in older patients. Idiopathic uveitis and other entities account for less than two-thirds of cases. Ophthalmologic entities are rare after 60 years of age. We also report for the first time the characteristics of uveitis after 70 years of age.
KeywordsDiagnosis Epidemiology Etiology Older patients Sarcoidosis Uveitis
Compliance with ethical standards
Conflict of interest
P. Grumet declares that he has no conflict of interest.
S. Kerever declares that he has no conflict of interest.
T. Gilbert declares that he has no conflict of interest.
L. Kodjikian has received speaker honorarium from ABBVIE, ALLERGAN, BAYER, NOVARTIS, ROCHE, and THEA.
M. Gerfaud-Valentin has received a speaker honorarium from SOBI.
A. De Parisot declares that she has no conflict of interest.
Y. Jamilloux has received a speaker honorarium from SOBI.
P. Sève has received speaker honorarium from ABBVIE, AKCEA THERAPEUTICS, GSK, NOVARTIS, SOBI, and ROCHE; he is a member of committee PEPITE (NOVARTIS).
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
This article does not contain any studies with animals performed by any of the authors.
Informed consent was obtained from all individual participants included in the study.
- 7.Kirsch O, Lautier-Frau M, Labetoulle M, Offret H, Frau E (2003) Characteristics of uveitis presenting de novo in the elderly. J Fr Ophtalmol 26(7):720–724Google Scholar
- 10.Makley TA, Orlando RG (1982) Uveitis in older patients. Ann Ophthalmol 14(10):942–944Google Scholar
- 12.de Parisot A, Kodjikian L, Errera M-H, Sedira N, Heron E, Pérard L et al (2017) Randomized controlled trial evaluating a standardized strategy for uveitis etiologic diagnosis (ULISSE). Am J OphthalmolGoogle Scholar
- 16.Rudwaleit M, van der Heijde D, Landewé R, Listing J, Akkoc N, Brandt J et al (2009) The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II): validation and final selection. Ann Rheum Dis 68(6):777–783CrossRefGoogle Scholar
- 18.International Study Group for Behçet’s Disease (1990) Criteria for diagnosis of Behçet’s disease. Lancet. 335(8697):1078–1080Google Scholar
- 24.Acharya NR, Browne EN, Rao N, Mochizuki M, International Ocular Sarcoidosis Working Group. (2018) Distinguishing features of ocular sarcoidosis in an international cohort of uveitis patients. Ophthalmology.;125(1):119–126Google Scholar
- 25.Fisson S, Ouakrim H, Touitou V, Baudet S, Ben Abdelwahed R, Donnou S et al (2013) Cytokine profile in human eyes: contribution of a new cytokine combination for differential diagnosis between intraocular lymphoma or uveitis. PLoS One [Internet] 8(2)Google Scholar
- 29.Tsen C-L, Chen S-C, Chen Y-S, Sheu S-J (2017) Uveitis as an initial manifestation of acquired immunodeficiency syndrome. Int J STD AIDS:956462417694569Google Scholar