Comparison of different devices to measure the intraocular pressure in thyroid-associated orbitopathy

  • Aylin Garip KueblerEmail author
  • Caroline Wiecha
  • Lukas Reznicek
  • Annemarie Klingenstein
  • Kathrin Halfter
  • Siegfried Priglinger
  • Christoph Hintschich
Oculoplastics and Orbit



To evaluate the correlation of the intraocular pressure measurements (IOP) with non-contact tonometer Corvis Scheimpflug technology (Corvis ST), Goldmann applanation tonometry (GAT), ocular response analyzer (ORA), and iCARE rebound tonometer in patients with thyroid-associated orbitopathy (TAO) and eye-healthy subjects (control group).


Twenty-nine consecutive patients with TAO (79% female) and 30 eye-healthy subjects (60% female) were included in this prospective, age- and sex-matched study. The IOP measurement with Corvis, ORA, GAT, iCARE, and central corneal thickness (CCT) with Corvis was obtained from all study participants.


The mean age of the patients was 51 ± 10 years in patients with TAO and 56 ± 13 years in the control group. The mean IOP measurements with GAT, Corvis, ORA, and iCARE were 15.93 ± 4.42 mmHg, 18.10 ± 7.54 mmHg, 18.40 ± 7.93 mmHg, and 16.61 ± 7.96 mmHg in patients with TAO and 14.52 ± 3.02 mmHg, 14.48 ± 3.38 mmHg, 15.29 ± 4.64 mmHg, and 14.13 ± 3.85 mmHg in the control group (P = 0.157, P = 0.004, P = 0.017, and P = 0.176 respectively). The mean CCT was 547.5 ± 39.2 μm in patients with TAO and 560.8 ± 49.8 μm in the control group ( P= 0.261).


The data collected shows an agreement between the iCARE and GAT IOP measurements in TAO patients and in eye-healthy patients. However, the mean value of IOP measurements with Corvis and ORA was significantly higher in patients with TAO in comparison with the control group (P = 0.044 and P = 0.029 respectively).


Thyroid-associated orbitopathy Intraocular pressure Corvis ST Goldmann applanation tonometry ORA iCARE 


Compliance with ethical standards

All procedures performed in this study were in accordance with the ethical standards of Institutional Review Board, Ludwig-Maximilians-University Eye Hospital, Munich in Germany, also with the 1964 Helsinki declaration and its later amendments. Informed consent was obtained from all individual participants included in the study.

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of OphthalmologyLudwig-Maximilians-UniversityMunichGermany
  2. 2.Private Praxis Professor Lachenmayr & PD ReznicekMunichGermany
  3. 3.The Institute for Medical Information Processing, Biometry, and EpidemiologyLudwig-Maximilians-UniversityMunichGermany

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