Dual antiplatelet therapy may lead to hemorrhagic complications in vitrectomy of proliferative diabetic retinopathy

  • Mohammad ZareiEmail author
Letter to the Editor

Dear editor,

I read with great interest the distinguished article by Meillon et al. “Antiplatelet and anticoagulant agents in vitreoretinal surgery: a prospective multicenter study involving 804 patients” [1]. The authors concluded that these drugs should be considered safe regarding hemorrhagic complications during vitreoretinal surgeries. Although valid in many cases, this may not be applicable in diabetics who need vitreoretinal surgery for complications of proliferative diabetic retinopathy (DR) while receiving dual antiplatelet therapy (DAPT) for recently placed coronary stents. As the authors discussed, currently there is no established consensus about the perioperative management of antiplatelet therapy (APT) in patients with coronary stents. There are some arguments against applying the conclusion of this study to these patients. First, only 12 out of 804 patients were receiving DAPT. Second, the type of vitreoretinal surgeries in these 12 patients was not specified; the...


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Conflict of interest

The author declares that there is no conflict of interest.


  1. 1.
    Meillon C, Gabrielle PH, Luu M, Aho-Glele LS, Bron AM, Creuzot-Garcher C (2018) Antiplatelet and anticoagulant agents in vitreoretinal surgery: a prospective multicenter study involving 804 patients. Graefes Arch Clin Exp Ophthalmol 256:461–467CrossRefGoogle Scholar
  2. 2.
    Rodriguez A, Guilera N, Mases A, Sierra P, Oliva JC, Colilles C (2018) Management of antiplatelet therapy in patients with coronary stents undergoing noncardiac surgery: association with adverse events. Br J Anaesth 120:67–76CrossRefGoogle Scholar
  3. 3.
    Columbo JA, Lambour JA, Sundling RA, Chauhan NB, Bessen SY, Linshaw DL, Riblet NBV, Goodney PP, Stone DH (2018) A meta-analysis of the impact of aspirin, clopidogrel, and dual antiplatelet therapy on bleeding complications in noncardiac surgery. Ann Surg 267:1–10CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Retina Service, Farabi Eye HospitalTehran University of Medical SciencesTehranIran

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