ADenoVirus Initiative Study in Epidemiology (ADVISE)—results of a multicenter epidemiology study in Germany
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Adenoviral conjunctivitis (AVC) represents a common, contagious form of conjunctivitis that may lead to persistent morbidity including vision-threatening subepithelial corneal scars and dry-eye-disease [1, 2, 3, 4, 5, 6]. Signs and symptoms can last up to 3 weeks, and patients have to be quarantined under strict hygiene instructions to prevent spread of the disease . Adenovirus shedding may last up to 14 days after the beginning of signs and symptoms with marked reduction after 1 week [7, 8]. Hence, it is crucial to identify AVC patients as early as possible [1, 2, 4, 9, 10]. However, for physicians it can be sometimes challenging to diagnose AVC based on clinical signs only [2, 9, 10]. Polymerase chain reaction (PCR) and cell culture are not used routinely, since these expensive techniques are not available in all offices and are not providing prompt results. AdenoPlus® is a rapid antigen-based immunoassay detecting the presence of adenovirus at the point of care...
ADVISE study group
Katharina Bayerl-Löhe, Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany
Daniel Böhringer, Eye center, University Hospital Freiburg, Freiburg, Germany
Daniela Goos, Eye center, University Hospital Freiburg, Freiburg, Germany
Silvia Herb, Department of Ophthalmology, Staedtisches Klinikum Karlsruhe, Karlsruhe, Germany
Konrad R. Koch, Department of Ophthalmology, University of Cologne, Cologne, Germany
Stefan Koinzer, Department of Ophthalmology, University of Kiel, Kiel, Germany
Ines M. Lanzl, Department of Ophthalmology, Technical University of Munich, Munich, Germany
Katrin Lorenz, Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany
Kristina Rist, Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany
Thomas Reinhard, Eye center, University Hospital Freiburg, Freiburg, Germany
Heike Scheer-Baumann, Department of Ophthalmology, Staedtisches Klinikum Karlsruhe, Karlsruhe, Germany
Compliance with ethical standards
Supported by VISUfarma, Netherlands. The sponsor participated in the design and conduct of the study, data collection; management, analysis, and interpretation of the data; and preparation and review of the manuscript.
Conflict of interest
The authors declare that they have no conflict of interest.
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