The fate of eyes with wet AMD beyond 4 years of anti-VEGF therapy
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We would like to address several challenges that have arisen from the study by Garweg et al.  which can be specifically summarized below.
The first inclusion criterion for the patients in this series was the presence of choroidal neovascularization (CNV) confirmed angiographically, in the context of wet age-related macular degeneration (wAMD) requiring intravitreal therapy, as indicated by the loss of best-corrected visual acuity (BCVA) and the manifestation of intraretinal and subretinal fluid in optical coherence tomography. The wAMD patients were not investigated with regard to the possible presence of the following six angiographic subtypes of CNV, namely, the occult, minimally classic, predominantly classic, mixed CNV, the retinal angiomatous proliferation, and the polypoidal choroidal vasculopathy. The treatment would have had to be individualized according to the existing angiographic subtype . Indocyanine green angiography should be a standard investigation...
Both authors (D.C and M.C) were involved in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.
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Conflict of interest
The authors declare that they have no conflict of interest.