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Incidence and timing of recurrence of optic neuritis

  • Neuroophthalmology
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To describe the incidence and timing of recurrence in patients with optic neuritis (ON).

Methods

Medical documents of adult patients with ON were retrospectively reviewed. The incidence and timing of recurrence of an ON episode were analyzed.

Results

One hundred eleven patients with ON were included in this study. Their mean follow-up duration was 4.1 ± 3.1 years. Seven relapses occurred after intravenous methylprednisolone treatment. The estimated cumulative incidence of recurrence in either eye was 26% at 1 year, 33% at 3 years, 37% at 5 years, and 50% at 10 years after the first episode of ON. If there was no recurrence until 6 months after the first episode of ON, the next 5-year recurrence-free survival probability was 67%. If there was no recurrence until 1 year, the next 5-year survival probability was 72%. If there was no recurrence until 2 years, the next 5-year survival probability was 81%. Relapse within 1 month and the presence of neuromyelitis optica-immunoglobulin G were factors that increased the recurrence rate over time.

Conclusions

We evaluated the incidence and timing of the recurrence in patients with ON after the first episode. Lower probability of recurrence was observed in patients with longer recurrence-free follow-up period. However, monitoring for recurrence is needed even in patients with a single episode of ON due to the increasing tendency of the estimated cumulative incidence of recurrence over many years.

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Author notes

  1. Sei Yeul Oh

    Present address: Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Ilwon-dong, Kangnam-gu, Seoul, Republic of Korea

Authors and Affiliations

  1. Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Ilwon-dong, Kangnam-gu, Seoul, Republic of Korea

    Kyung-Ah Park

  2. Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

    Ju-Hong Min & Byoung Joon Kim

Authors
  1. Kyung-Ah Park
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  2. Sei Yeul Oh
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Contributions

Involved in study concept and design: Kyung-Ah Park and Sei Yeul Oh, Sungkyunkwan University, Neuro-Ophthalmology

Involved in collecting data: Kyung-Ah Park and Sei Yeul Oh, Sungkyunkwan University, Neuro-Ophthalmology, and Ju-Hong Min and Byoung Joon Kim, Sungkyunkwan University, Neurology

Involved in analysis and interpretation of data: Kyung-Ah Park, Sungkyunkwan University, Neuro-Ophthalmology, and Ju-Hong Min and Byoung Joon Kim, Sungkyunkwan University, Neurology

Involved in critical revision of manuscript for intellectual content: Sei Yeul Oh, Sungkyunkwan University, Neuro-Ophthalmology, and Ju-Hong Min and Byoung Joon Kim, Sungkyunkwan University, Neurology

Corresponding author

Correspondence to Sei Yeul Oh.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This study was approved by the Institutional Review Board of Samsung Medical Center (Seoul, South Korea). This study was conducted in accordance with the tenets of the Declaration of Helsinki.

Informed consent

Informed consent was not obtained in this study. Identifying information about participants was not presented in this study.

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Park, KA., Oh, S.Y., Min, JH. et al. Incidence and timing of recurrence of optic neuritis. Graefes Arch Clin Exp Ophthalmol 257, 651–655 (2019). https://doi.org/10.1007/s00417-018-04217-7

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  • DOI: https://doi.org/10.1007/s00417-018-04217-7

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