Incidence and timing of recurrence of optic neuritis
- 41 Downloads
To describe the incidence and timing of recurrence in patients with optic neuritis (ON).
Medical documents of adult patients with ON were retrospectively reviewed. The incidence and timing of recurrence of an ON episode were analyzed.
One hundred eleven patients with ON were included in this study. Their mean follow-up duration was 4.1 ± 3.1 years. Seven relapses occurred after intravenous methylprednisolone treatment. The estimated cumulative incidence of recurrence in either eye was 26% at 1 year, 33% at 3 years, 37% at 5 years, and 50% at 10 years after the first episode of ON. If there was no recurrence until 6 months after the first episode of ON, the next 5-year recurrence-free survival probability was 67%. If there was no recurrence until 1 year, the next 5-year survival probability was 72%. If there was no recurrence until 2 years, the next 5-year survival probability was 81%. Relapse within 1 month and the presence of neuromyelitis optica-immunoglobulin G were factors that increased the recurrence rate over time.
We evaluated the incidence and timing of the recurrence in patients with ON after the first episode. Lower probability of recurrence was observed in patients with longer recurrence-free follow-up period. However, monitoring for recurrence is needed even in patients with a single episode of ON due to the increasing tendency of the estimated cumulative incidence of recurrence over many years.
KeywordsIncidence Timing Recurrence Optic neuritis
Involved in study concept and design: Kyung-Ah Park and Sei Yeul Oh, Sungkyunkwan University, Neuro-Ophthalmology
Involved in collecting data: Kyung-Ah Park and Sei Yeul Oh, Sungkyunkwan University, Neuro-Ophthalmology, and Ju-Hong Min and Byoung Joon Kim, Sungkyunkwan University, Neurology
Involved in analysis and interpretation of data: Kyung-Ah Park, Sungkyunkwan University, Neuro-Ophthalmology, and Ju-Hong Min and Byoung Joon Kim, Sungkyunkwan University, Neurology
Involved in critical revision of manuscript for intellectual content: Sei Yeul Oh, Sungkyunkwan University, Neuro-Ophthalmology, and Ju-Hong Min and Byoung Joon Kim, Sungkyunkwan University, Neurology
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
This study was approved by the Institutional Review Board of Samsung Medical Center (Seoul, South Korea). This study was conducted in accordance with the tenets of the Declaration of Helsinki.
Informed consent was not obtained in this study. Identifying information about participants was not presented in this study.
- 4.Beck RW, Gal RL, Bhatti MT, Brodsky MC, Buckley EG, Chrousos GA, Corbett J, Eggenberger E, Goodwin JA, Katz B, Kaufman DI, Keltner JL, Kupersmith MJ, Miller NR, Moke PS, Nazarian S, Orengo-Nania S, Savino PJ, Shults WT, Smith CH, Trobe JD, Wall M, Xing D (2004) Visual function more than 10 years after optic neuritis: experience of the optic neuritis treatment trial. Am J Ophthalmol 137:77–83CrossRefGoogle Scholar
- 5.Wingerchuk DM, Banwell B, Bennett JL, Cabre P, Carroll W, Chitnis T, de Seze J, Fujihara K, Greenberg B, Jacob A, Jarius S, Lana-Peixoto M, Levy M, Simon JH, Tenembaum S, Traboulsee AL, Waters P, Wellik KE, Weinshenker BG (2015) International consensus diagnostic criteria for neuromyelitis optica spectrum disorders. Neurology 85:177–189. https://doi.org/10.1212/wnl.0000000000001729 CrossRefGoogle Scholar
- 6.Polman CH, Reingold SC, Edan G, Filippi M, Hartung HP, Kappos L, Lublin FD, Metz LM, McFarland HF, O'Connor PW, Sandberg-Wollheim M, Thompson AJ, Weinshenker BG, Wolinsky JS (2005) Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald criteria”. Ann Neurol 58:840–846. https://doi.org/10.1002/ana.20703 CrossRefGoogle Scholar
- 7.McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD, McFarland HF, Paty DW, Polman CH, Reingold SC, Sandberg-Wollheim M, Sibley W, Thompson A, van den Noort S, Weinshenker BY, Wolinsky JS (2001) Recommended diagnostic criteria for multiple sclerosis: guidelines from the international panel on the diagnosis of multiple sclerosis. Ann Neurol 50:121–127CrossRefGoogle Scholar
- 8.Wingerchuk DM, Lennon VA, Pittock SJ, Lucchinetti CF, Weinshenker BG (2006) Revised diagnostic criteria for neuromyelitis optica. Neurology 66:1485–1489. https://doi.org/10.1212/01.wnl.0000216139.44259.74 CrossRefGoogle Scholar