Functional and anatomical outcomes following surgical management of persistent fetal vasculature: a single-center experience of 44 cases

  • Murat Karacorlu
  • Mumin Hocaoglu
  • Isil Sayman Muslubas
  • Serra Arf
  • Mehmet Giray Ersoz
  • Omer Uysal
Retinal Disorders
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Abstract

Purpose

To investigate the functional and anatomical outcomes following surgical management of persistent fetal vasculature (PFV).

Methods

Single-center, retrospective, interventional consecutive case series of 41 patients (44 eyes) who underwent vitrectomy with or without lensectomy through a limbal or pars plana/plicata approach with diagnosis of anterior, posterior, or combined anterior and posterior segment PFV were included.

Results

The median age at the time of surgery was 3 months (range, 1–36 months), and the mean follow-up period was 37.2 ± 38.1 months (range, 12–164 months). Of the 44 eyes, 5 (11%) had clinical and ultrasonographic findings of anterior PFV, 5 (11%) had posterior PFV, and 34 (78%) had components of both anterior and posterior disease. At the last visit, 38 eyes (87%) were aphakic, 5 eyes (11%) were phakic, and 1 eye (2%) was pseudophakic. The mean Snellen equivalent VA at the final visit for the 14 (32%) eyes with measurable VA was 20/283. Nine (20%) eyes had final VA of only light perception or no light perception. The remaining 21 (48%) eyes behaved consistently with form vision, but the patients were not able to report VA.

Conclusions

Most of the eyes achieved at least form vision, with acceptable postoperative complication rates. Functional and anatomical outcomes are not strictly dependent on axial length, and microphthalmic eyes with mild posterior segment involvement have the potential for good visual results. Outcomes after surgery for posterior PFV associated with tractional retinal detachment are limited. Anatomical success does not always equate to functional improvement.

Keywords

Pediatric vitrectomy Persistent fetal vasculature Persistent hyperplastic primary vitreous Tractional retinal detachment 
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Notes

Compliance with ethical standards

Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

For this type of study, formal consent is not required.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Murat Karacorlu
    • 1
  • Mumin Hocaoglu
    • 1
  • Isil Sayman Muslubas
    • 1
  • Serra Arf
    • 1
  • Mehmet Giray Ersoz
    • 1
  • Omer Uysal
    • 2
  1. 1.Istanbul Retina InstituteIstanbulTurkey
  2. 2.School of Medicine, Deparment of BiostatisticsBezmialem Vakif UniversityIstanbulTurkey

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