Comparison of conventional color fundus photography and multicolor imaging in choroidal or retinal lesions
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Our purpose was to compare the characteristics of the retinal and choroidal lesions including choroidal nevus, choroidal melanoma and congenital hypertrophy of the retina pigment epithelium using conventional color fundus photography (CFP) and multicolor imaging (MCI).
The paired images of patients with retinal or choroidal lesions were assessed for the visibility of lesion’s border, halo and drusen using a grading scale (0–2). The area of the lesion was measured on both imaging modalities. The same grading was also done on the individual color channels of MCI for a further evaluation.
Thirty-three eyes of 33 patients were included. There were no significant differences in the mean border, drusen and halo visibility scores between the two imaging modalities (p = 0.12, p = 0.70, p = 0.35). However, the mean area of the lesion was significantly smaller on MCI than that on CFP (14.9±3.3 versus 18.7±3.4 mm2, p = 0.01).
The appearance of choroidal and/ or retinal lesions on MCI may be different than that on CFP. Though MCI can provide similar information with CFP for the features of retinal and/ or choroidal lesions including border, halo and drusen; the infrared light reflection on MCI underestimates the extent of the choroidal lesion by 33%.
KeywordsMulticolor imaging Fundus photography Choroidal nevus Choroidal melanoma Congenital hypertrophy of the retina pigment epithelium Pseudocolor
This work was supported in part by an unrestricted grant from NIH grant R01 EY016323-09A1 (D.U.B.) and a core grant from the National Eye Institute P30 EY022589, and an unrestricted grant from Research to Prevent Blindness, NY (WRF). The funding organizations had no role in the design or conduct of this research.
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Conflict of interest
All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
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