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Real-life clinical data for dexamethasone and ranibizumab in the treatment of branch or central retinal vein occlusion over a period of six months

  • Sibylle WinterhalterEmail author
  • Annabelle Eckert
  • Gerrit-Alexander vom Brocke
  • Alice Schneider
  • Dominika Pohlmann
  • Daniel Pilger
  • Antonia M. Joussen
  • Matus Rehak
  • Ulrike Grittner
Retinal Disorders
  • 529 Downloads

Abstract

Purpose

To evaluate the therapeutic outcome for dexamethasone implant (DEX) or intravitreal ranibizumab (IVR) injections over 6 months in patients with macular edema due to branch or central retinal vein occlusion (BRVO, CRVO), in a real-life setting.

Methods

A total of 107 patients with BRVO or CRVO were included into this retrospective single-center observational study. Patients were treated with monotherapy consisting of DEX or three monthly IVR injections following a pro re nata regimen (PRN). Best-corrected visual acuity (BCVA), central retinal thickness (CRT) and intraocular pressure (IOP) were compared between the two therapy groups after 1, 3 and 6 months.

Results

BRVO patients treated with DEX achieved a statistically significant gain in BCVA measured in logMAR after 1 month (mean gain, 95% CI: 0.21, 0.08–0.34, p = 0.001), 3 months (0.16, 0.03–0.28, p = 0.012) and 6 months (0.19, 0.07–0.32, p = 0.002), whereas patients treated with IVR showed a statistically significant BCVA gain in month 3 (mean improvement, 95% CI: 0.13, 0.01–0.26, p = 0.039) and month 6 (0.16, 0.03–0.29, p = 0.018). BCVA in CRVO patients with DEX worsened slightly at month 6 (mean worsening, 95% CI: −0.08, −0.24 to 0.08, p = 0.305), while IVR treated-patients achieved a statistically significant BCVA gain at 3 months (mean improvement, 95% CI: 0.14, 0.02–0.25, p = 0.021). Both therapies were accompanied by statistically significant CRT reductions of 150 to 200 μm (median). Adverse events reported were predictable and limited.

Conclusions

In a clinical setting, comparable improvement in BCVA and CRT were observed after DEX and IVR injections for treatment of BRVO. CRVO patients showed greater benefit with IVR.

Keywords

Dexamethasone Ranibizumab Branch retinal vein occlusion Central retinal vein occlusion Macular edema Real-world data 

Notes

Acknowledgements

We thank Dr. Patricia Buchholz for her advice.

Compliance with ethical standards

For this type of study, formal consent is not required.

Informed consent was obtained from all individual participants included in the study.

Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements) or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2017

Authors and Affiliations

  • Sibylle Winterhalter
    • 1
    Email author
  • Annabelle Eckert
    • 1
    • 2
  • Gerrit-Alexander vom Brocke
    • 1
  • Alice Schneider
    • 3
  • Dominika Pohlmann
    • 1
  • Daniel Pilger
    • 1
  • Antonia M. Joussen
    • 1
  • Matus Rehak
    • 1
    • 4
  • Ulrike Grittner
    • 3
  1. 1.Department of Ophthalmology, Campus Virchow-KlinikumCharité – University Medicine Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of HealthBerlinGermany
  2. 2.Ophthalmicus AugentagesklinikVillingen-SchwenningenGermany
  3. 3.Department of Biostatistics and Clinical EpidemiologyCharité – University Medicine Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of HealthBerlinGermany
  4. 4.Department of OphthalmologyUniversitätsklinikum LeipzigLeipzigGermany

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