Congenital optic tract syndrome misdiagnosed with normal tension glaucoma

  • Eun Ji Lee
  • Jae Hyoung Kim
  • Jeong-Min HwangEmail author
Letter to the Editor

Dear Editor,

Congenital optic tract syndrome (COTS) is a rare condition characterized by an isolated hypoplasia of unilateral optic tract accompanied by homonymous hemianopia [ 1, 2]. Although the diagnosis is confirmed by magnetic resonance (MR) imaging of the brain, it is prone to remain undetected because the lesion is generally subtle or the MR image is not of sufficient resolution. Up to now, only a limited number of case reports have described MR feature of COTS [ 1, 2, 3]. We recently experienced two cases with several months of treatment for bilateral normal-tension glaucoma in another hospital, which had been finally diagnosed with COTS with high-resolution brain imaging.
  1. Case 1
    A 40-year-old female had been treated for bilateral normal-tension glaucoma. Best-corrected visual acuities (BCVAs) were 20/20 OD, and 20/30 OS. Color vision was normal. Fundus examination showed bilaterally enlarged cupping with mild temporal pallor. Perimetric examination revealed left homonymous...


Glaucoma Retinal Nerve Fiber Layer Visual Field Defect Optic Tract Ganglion Cell Layer 
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Conflict of interest statement

All authors certify that they have NO affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge, or beliefs) in the subject matter or materials discussed in this manuscript.

No conflicting relationships exist for any author.

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Financial disclosure

The authors have no proprietary or commercial interest in any materials discussed in this article.


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© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Department of Ophthalmology, Seoul National University College of MedicineSeoul National University Bundang HospitalSeongnamKorea
  2. 2.Department of Radiology, Seoul National University College of MedicineSeoul National University Bundang HospitalSeongnamKorea

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