Retinal sensitivity after selective retina therapy (SRT) on patients with central serous chorioretinopathy

  • Ayako Yasui
  • Manabu YamamotoEmail author
  • Kumiko Hirayama
  • Kunihiko Shiraki
  • Dirk Theisen-Kunde
  • Ralf Brinkmann
  • Yoko Miura
  • Takeya Kohno
Retinal Disorders



To assess retinal sensitivity after selective retina therapy (SRT) in patients with central serous chorioretinopathy (CSCR).


Seventeen eyes of 17 patients with CSCR lasting longer than 3 months were treated with SRT (wavelength 527 nm Nd: YLF laser, 50–150 μJ/pulse, spot diameter 200 μm). Measurement of best-corrected visual acuity (BCVA), optical coherence tomography, fluorescence angiography, and microperimetry (MAIA™) were conducted before, and 1 and 3 months after treatment. Microperimetry was performed in the central 10° of the macula, and at the test spots applied near the vascular arcade for energy titration. In addition to the treatment effect, all test irradiation spots were thoroughly analyzed with regard to their sensitivity changes.


The mean logMAR BCVA had improved from 0.06 to 0.02 after 1 month (p = 0.11) and to 0.03 after 3 months (p = 0.003). Eleven out of 17 eyes (64.7%) showed complete resolution of subretinal fluid after 3 months. Retinal sensitivity in the central 10° increased after 1 month (median: 25.9 dB) and 3 months (26.6 dB) as compared with that before treatment (23.0 dB) (p < 0.001). Analysis of the test spots revealed a slight decrease in retinal sensitivity after 1 month (ΔdB = −0.5 ± 2.1, p = 0.006), while there was no significant difference from baseline after 3 months (ΔdB = −0.3 ± 2.2, p = 0.09). No correlation was found between laser energy and the change in focal retinal sensitivity.


Results suggest that SRT is a safe and effective treatment for persistent CSCR and does not leave permanent scotoma regardless of irradiation energy in the therapeutic range.


Retinal sensitivity Microperimetry Central serous chorioretinopathy Subvisible laser Retinal pigment epithelium 



Authors would like to thank Veit Danicke for his technical assistance, and Kerstin Schlott for her support in analytical work.

Compliance with ethical standards


No funding was received for this research.

Conflict of Interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge, or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. For this type of study formal consent is not required.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Department of Ophthalmology and Visual SciencesOsaka City University Graduate School of MedicineOsakaJapan
  2. 2.Medical Laser Center Lübeck GmbHLübeckGermany
  3. 3.Institute of Biomedical OpticsUniversity of LübeckLübeckGermany
  4. 4.Department of OphthalmologyUniversity of LübeckLübeckGermany

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