Subfoveal choroidal thickness as a predictor of treatment response to anti-vascular endothelial growth factor therapy for polypoidal choroidal vasculopathy

  • Hyesun Kim
  • Sung Chul Lee
  • Kye Yoon Kwon
  • Ji Hwan Lee
  • Hyoung Jun Koh
  • Suk Ho Byeon
  • Sung Soo Kim
  • Min Kim
  • Christopher Seungkyu LeeEmail author
Retinal Disorders



To investigate whether subfoveal choroidal thickness predicted treatment response to anti-vascular endothelial growth factor (VEGF) in polypoidal choroidal vasculopathy (PCV).


This retrospective observational case series included 66 eyes of 60 patients who were diagnosed with new-onset PCV and who were followed for a minimum of 6 months. Patients received three monthly intravitreal injections of 0.5 mg ranibizumab or 1.25 mg bevacizumab, at baseline, month 1, and month 2. “Good responders” were defined as those who showed complete resolution of subretinal and/or intraretinal fluid at month 3 after the loading injections, whereas “poor responders” were defined as those who showed persistent retinal fluid on optical coherence tomography (OCT) at month 3 after treatment. Differences in best-corrected visual acuity, indocyanine green angiography, and spectral domain-OCT findings at baseline were analyzed between the two groups.


The mean patient age was 68.2 ± 9.7 years, and the mean follow-up period was 27 ± 21 months. The mean subfoveal choroidal thickness was 273 ± 117 μm, and choroidal vascular hyperpermeability was observed in 35 eyes (53.0 %). Thirty-three eyes (50 %) showed good response to treatment, and a thinner subfoveal choroid at baseline significantly correlated with favorable treatment response (P = 0.024). However, there was no significant relationship between treatment response and choroidal vascular hyperpermeability (P = 0.999).


The subfoveal choroid was found to be significantly thinner among patients who achieved complete resolution of macular exudation after three loading injections of anti-VEGF agents.


Anti-vascular endothelial growth factor Polypoidal choroidal vasculopathy Subfoveal choroidal thickness 


Compliance with ethical standards


No funding was received for this research.

Conflict of Interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

For this type of study, formal consent is not required.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Hyesun Kim
    • 1
    • 2
  • Sung Chul Lee
    • 1
  • Kye Yoon Kwon
    • 1
  • Ji Hwan Lee
    • 1
  • Hyoung Jun Koh
    • 1
  • Suk Ho Byeon
    • 1
  • Sung Soo Kim
    • 1
  • Min Kim
    • 1
  • Christopher Seungkyu Lee
    • 1
    Email author
  1. 1.The Institute of Vision Research, Department of Ophthalmology, Severance HospitalYonsei University College of MedicineSeoulKorea
  2. 2.Siloam Eye HospitalSeoulKorea

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