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Enhanced-depth optical coherence tomography for imaging horizontal rectus muscles in Graves’ orbitopathy

  • Nathanael U. Häner
  • Muriel Dysli
  • Mathias Abegg
  • Martin S. ZinkernagelEmail author
Inflammatory Disorders

Abstract

Purpose

Graves’ orbitopathy (GO) is an extraocular eye disease with symptoms ranging from minor discomfort from dry eyes to strabismus and visual loss. One of the hallmarks of active GO is visible hyperemia at the insertion of the extraocular muscles. The aim of the present study was to evaluate the use of enhanced-depth imaging spectral domain anterior segment optical coherence tomography (EDI SD AS-OCT) for detecting pathological changes in horizontal recti muscles of patients with GO.

Methods

Prospective cross sectional study of 27 eyes. Only women were included. EDI AS-OCT was used to measure the thickness of the tendons of the horizontal recti muscles in a predefined area in patients with GO and healthy controls.

Results

EDI AS-OCT was able to image the tendons of the horizontal recti muscles in both healthy controls and patients suffering from GO. The mean thickness of the medial rectus muscle (MR) tendon was 256.4 μm [±17.13 μm standard deviation (SD)] in the GO group and, therefore, significantly thicker (p = 0.046) than in the healthy group which had a mean thickness of 214.7 μm (±5.516 μm SD). There was no significant difference in the mean thickness of the tendon of the lateral recti muscles (LRs) between these groups.

Conclusion

This is the first report showing that EDI AS-OCT is suitable to detect swelling at the insertion site of the MR muscle in GO. MR tendon thickness may be a useful parameter to monitor activity in these patients.

Keywords

Extraocular eye muscles Myopathy Anterior segment OCT Graves’ orbitopathy 

Notes

Conflict of interest

The authors acknowledge the use of the facilities and scientific and technical assistance of the Department for Clinical Research (DCR) of the University of Bern. These studies were supported by grants from the Inselspital Bern and the OPOS Foundation. Dr. Zinkernagel has served as a speaker for and has received funding from Heidelberg Engineering GMbH, Germany

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Nathanael U. Häner
    • 1
  • Muriel Dysli
    • 1
    • 2
  • Mathias Abegg
    • 1
  • Martin S. Zinkernagel
    • 1
    • 2
    Email author
  1. 1.Department of Ophthalmology, InselspitalBern University Hospital, and University of BernBernSwitzerland
  2. 2.Department of Clinical ResearchUniversity Hospital BernBernSwitzerland

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