Enhanced-depth optical coherence tomography for imaging horizontal rectus muscles in Graves’ orbitopathy
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Graves’ orbitopathy (GO) is an extraocular eye disease with symptoms ranging from minor discomfort from dry eyes to strabismus and visual loss. One of the hallmarks of active GO is visible hyperemia at the insertion of the extraocular muscles. The aim of the present study was to evaluate the use of enhanced-depth imaging spectral domain anterior segment optical coherence tomography (EDI SD AS-OCT) for detecting pathological changes in horizontal recti muscles of patients with GO.
Prospective cross sectional study of 27 eyes. Only women were included. EDI AS-OCT was used to measure the thickness of the tendons of the horizontal recti muscles in a predefined area in patients with GO and healthy controls.
EDI AS-OCT was able to image the tendons of the horizontal recti muscles in both healthy controls and patients suffering from GO. The mean thickness of the medial rectus muscle (MR) tendon was 256.4 μm [±17.13 μm standard deviation (SD)] in the GO group and, therefore, significantly thicker (p = 0.046) than in the healthy group which had a mean thickness of 214.7 μm (±5.516 μm SD). There was no significant difference in the mean thickness of the tendon of the lateral recti muscles (LRs) between these groups.
This is the first report showing that EDI AS-OCT is suitable to detect swelling at the insertion site of the MR muscle in GO. MR tendon thickness may be a useful parameter to monitor activity in these patients.
KeywordsExtraocular eye muscles Myopathy Anterior segment OCT Graves’ orbitopathy
Conflict of interest
The authors acknowledge the use of the facilities and scientific and technical assistance of the Department for Clinical Research (DCR) of the University of Bern. These studies were supported by grants from the Inselspital Bern and the OPOS Foundation. Dr. Zinkernagel has served as a speaker for and has received funding from Heidelberg Engineering GMbH, Germany
- 5.Johnson KT, Wittig A, Loesch C, Esser J, Sauerwein W, Eckstein AK (2010) A retrospective study on the efficacy of total absorbed orbital doses of 12, 16 and 20 Gy combined with systemic steroid treatment in patients with Graves’ orbitopathy. Graefe’s archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle. Ophthalmologie 248:103–109Google Scholar
- 6.Bartalena L, Baldeschi L, Dickinson A, Eckstein A, Kendall-Taylor P, Marcocci C, Mourits M, Perros P, Boboridis K, Boschi A, Curro N, Daumerie C, Kahaly GJ, Krassas GE, Lane CM, Lazarus JH, Marino M, Nardi M, Neoh C, Orgiazzi J, Pearce S, Pinchera A, Pitz S, Salvi M, Sivelli P, Stahl M, von Arx G, Wiersinga WM (2008) Consensus statement of the European Group on Graves’ orbitopathy (EUGOGO) on management of GO. Eur J Endocrinol 158:273–285CrossRefPubMedGoogle Scholar
- 9.Nishida Y, Tian S, Isberg B, Hayashi O, Tallstedt L, Lennerstrand G (2002) Significance of orbital fatty tissue for exophthalmos in thyroid-associated ophthalmopathy. Graefe’s archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle. Ophthalmologie 240:515–520Google Scholar
- 10.Campi I, Vannucchi GM, Minetti AM, Dazzi D, Avignone S, Covelli D, Curro N, Ratiglia R, Guastella C, Pignataro L, Beck-Peccoz P, Salvi M (2013) A quantitative method for assessing the degree of axial proptosis in relation to orbital tissue involvement in Graves’ orbitopathy. Ophthalmology 120:1092–1098CrossRefPubMedGoogle Scholar