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A case–control study to assess aspirin as a risk factor of bleeding in rhegmatogenous retinal detachment surgery

  • Retinal Disorders
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Abstract

Purpose

The purpose of this study was to evaluate the hemorrhagic risk factors during the management of primary rhegmatogenous retinal detachment (RD).

Methods

Three hundred and twenty-two patients with (n = 74) or without (n = 248) bleeding (anterior segment, choroidal, intravitreal and/or subretinal) during or after RD surgery were included in this case–control study. Exclusion criteria were: history of trauma, vitreoretinal surgery, diabetic retinopathy, and taking clopidogrel and/or a vitamin K antagonist. Univariate and multivariate analyses were performed to identify risk factors of perioperative bleeding.

Results

Aspirin was not significantly associated with bleeding complications during or after surgery (p = 0.8). Scleral buckling (with cryotherapy and gas tamponnade) was performed in 47 % of the cases and pars plana vitrectomy in 53 % of the cases. Independent risk factors of perioperative hemorrhage were the number of cryotherapy impacts (odds ratio =1.12 [1.06; 1.20], 95 % confidence interval), transscleral drainage (OR = 4.22 [1.62; 10.98]), and use of pars plana vitrectomy (OR = 3.39 [1.36; 8.47]). Bleeding complications were associated with a lower single-operation anatomical success rate (74 % vs 84 %, p = 0.03). There was also a trend toward an association between bleeding complications, a higher total number of RD recurrences (0.19 ± 0.5 in the non-bleeding group vs 0.34 ± 0.6, p = 0.06), and a lower final visual acuity (0.5 ± 0.6 logMAR vs 0.7 ± 0.7, p = 0.09).

Conclusion

This case–control study suggests that aspirin is not a major risk factor of hemorrhagic complications during and after RD surgery. Perioperative bleeding leads to a lower single-operation anatomic success rate.

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Conflict of interest

The authors have no proprietary or commercial interest in any materials discussed in this article.

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Authors and Affiliations

  1. UJF-Grenoble 1, Grenoble, F-38041, France

    Eva Brillat, Jean-Louis Quesada, Pierre Albaladejo, Florent Aptel, Jean-Paul Romanet & Christophe Chiquet

  2. Department of Ophthalmology, University Hospital, CHU Grenoble, Grenoble Cedex 09, F-38043, France

    Eva Brillat, Karine Palombi, Diane Bernheim, Florent Aptel, Jean-Paul Romanet & Christophe Chiquet

  3. Kleber Center of Ophthalmology, Lyon, France

    Frédéric Rouberol

  4. INSERM CIC03, Clinical Research Center, University Hospital, CHU Grenoble, Grenoble, F-38043, France

    Jean-Louis Quesada

  5. Department of Anaesthesia, University Hospital, CHU Grenoble, Grenoble, F-38043, France

    Pierre Albaladejo

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  1. Eva Brillat
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  2. Frédéric Rouberol
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  3. Karine Palombi
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  4. Jean-Louis Quesada
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  5. Diane Bernheim
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  6. Pierre Albaladejo
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  8. Jean-Paul Romanet
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  9. Christophe Chiquet
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Correspondence to Christophe Chiquet.

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Brillat, E., Rouberol, F., Palombi, K. et al. A case–control study to assess aspirin as a risk factor of bleeding in rhegmatogenous retinal detachment surgery. Graefes Arch Clin Exp Ophthalmol 253, 1899–1905 (2015). https://doi.org/10.1007/s00417-014-2900-3

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  • DOI: https://doi.org/10.1007/s00417-014-2900-3

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