Acute central serous chorioretinopathy: a correlation study between fundus autofluorescence and spectral-domain OCT

  • Pierluigi Iacono
  • Parodi Maurizio Battaglia
  • Alexandros Papayannis
  • Carlo La Spina
  • Monica Varano
  • Francesco Bandello
Retinal Disorders



To evaluate the correlation between fundus autofluorescence (FAF) and spectral-domain OCT (SD-OCT) morphological analysis in eyes with acute central serous chorioretinopathy (CSCR).


Thirty-one patients with a first episode of CSCR and symptom duration of less than 6 weeks were prospectively enrolled. FAF and SD-OCT examination were performed at baseline and at 2-month intervals. Main outcome measure was the correlation between FAF and SD-OCT retinal morphology.


At baseline, 30/31 and 29/31 eyes showed a macular hypo-AF, corresponding to the neurosensory retinal detachment (SRD), on shortwave-FAF (SW-FAF) and near-infrared-FAF (NIR-FAF), respectively. While the SRD resolved, both FAF techniques showed a granular hyper-AF in 31 eyes. At first examination, SD-OCT confirmed the SRD with a photoreceptor outer-segment (OS) elongation in all cases. During SRD resolution, the photoreceptor layer appeared thicker and fragmented. Multiple hyper-reflective precipitates were detected in the outer plexiform and nuclear layer and between the photoreceptors and appeared colocalized with the hyper-AF dots composing the granular hyper-AF. After SRD resolution, the hypo-AF area reverted to a normal pattern on SW-FAF in all eyes and in 25/31 on NIR-FAF. Examination at 12 months showed that the granular hyper-AF was still detectable in 54 % eyes, whereas 6/31 eyes showed hypo-AF dots on NIR-FAF. On SD-OCT, the junction IS/OS was identifiable in 11/31 eyes soon after the SRD resolution and appeared completely restored in all patients at the final visit.


The simultaneous acquisition of FAF and SD-OCT provides detailed findings of retinal abnormalities of CSCR and may help to understand the evolving process linked to CSCR.


Fundus autofluorescence Shortwave-FAF Near infrared-FAF Spectral domain OCT Central serous chorioretinopathy 



The research for this paper was financially supported by Ministry of Health and Fondazione Roma.

Conflict of interest statement

All authors contributing to the present paper certify that they have NO financial interest or non-financial interest in the subject matter or materials discussed in this manuscript.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Pierluigi Iacono
    • 1
  • Parodi Maurizio Battaglia
    • 2
  • Alexandros Papayannis
    • 3
  • Carlo La Spina
    • 2
  • Monica Varano
    • 1
  • Francesco Bandello
    • 2
  1. 1.Fondazione G. B. Bietti per l’OftalmologiaIRCCS (Istituto di Ricovero e Cura a Carattere Scientifico)RomeItaly
  2. 2.Department of OphthalmologyUniversity Vita-Salute, Scientific Institute San RaffaeleMilanItaly
  3. 3.Department of Ophthalmology, Ospedale Conegliano VenetoConeglianoItaly

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