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Fundus autofluorescence in patients with retinal pigment epithelial (RPE) tears: an in-vivo evaluation of RPE resurfacing

  • Randev Mendis
  • Noemi Lois
Retinal Disorders

Abstract

Aim

Investigate RPE resurfacing by changes in fundus autofluorescence (AF) in patients with retinal pigment epithelial (RPE) tears secondary to age-related macular degeneration (AMD).

Methods

A retrospective case series of patients presenting with RPE tears from 1 March 2008 to 1 April 2011. The pattern and area of AF signal distribution in RPE tears were evaluated. The change in the size of the area of debrided RPE over the follow-up period was used as the main outcome measure. A reduction in this area was termed “RPE resurfacing”, and an enlargement termed “progression of RPE cell loss”.

Results

Thirteen patients (14 eyes) with RPE tears (mean age 82 years) were included in this study. The mean baseline area of reduced AF signal was 4.1 mm2 (range 0.33–14.9, median 0.29). “Resurfacing” of the RPE occurred in ten eyes and “progression of RPE cell loss” in four eyes after a median follow-up of 11.5 months (range, 1–39). The mean area of healing was 2.0 mm2, and progression was 1.78 mm2.

Conclusion

A consistent AF pattern was observed in patients with RPE tears. RPE resurfacing over the area of the RPE tear occurred, to a varying degree, in the majority of the cases.

Keywords

Retinal pigment epithelium Retinal pigment epithelial tears Autofluorescence Age-related macular degeneration 

Notes

Conflict of interests

The authors have no financial/conflicting interests to disclose.

References

  1. 1.
    Hoskin A, Bird AC, Sehmi K (1981) Tears of detached retinal pigment epithelium. Br J Ophthalmol 65:417–422PubMedCentralPubMedCrossRefGoogle Scholar
  2. 2.
    Gass JDM (1984) Pathogenesis of tears of the retinal pigment epithelium. Br J Ophthalmol 68:513–519PubMedCentralPubMedCrossRefGoogle Scholar
  3. 3.
    Barondes MJ, Pagliarini S, Chisholm IH et al (1992) Controlled trial of laser photocoagulation of pigment epithelial detachments in the elderly: 4 year review. Br J Ophthalmol 76:5–7PubMedCentralPubMedCrossRefGoogle Scholar
  4. 4.
    Gelisken F, Indhofen W, Partsch M et al (1984) Retinal pigment epithelial tea after photodynamic therapy for choroidal neovascularization. Am J Ophthalmol 98:700–706Google Scholar
  5. 5.
    Goldstein M, Heilweil G, Barak A et al (2005) Retinal pigment epithelial tear following photodynamic therapy for choroidal neovascularization secondary to AMD. Eye 19(12):1315–1324PubMedCrossRefGoogle Scholar
  6. 6.
    Meyer CH, Mennel S, Schmidt JC, Kroll P (2006) Acute retinal pigment epithelial tear following intravitreal bevacizumab (Avastin) injection for occult choroidal revascularization secondary to age related macular degeneration. Br J Ophthalmol 90:1207–1208PubMedCentralPubMedCrossRefGoogle Scholar
  7. 7.
    Carvounis PE, Kopel AC, Benz MS (2007) Retinal pigment epithelium tears following ranibizumab for exudative age related macular degeneration. Am J Ophthalmol 143:504–505PubMedCrossRefGoogle Scholar
  8. 8.
    Bakri SJ, Kitzmann AS (2007) Retinal pigment epithelial tear after intravitreal ranibizumab. Am J Ophthalmol 143:505–507PubMedCrossRefGoogle Scholar
  9. 9.
    Chan CK, Meyer CH, Gross JG et al (2007) Retinal pigment epithelial tears after intravitreal bevacizumab injection for neovascular age-related macular degeneration. Retina 27:541–551PubMedCrossRefGoogle Scholar
  10. 10.
    Chang LK, Sarraf D (2007) Tears of the retinal pigment epithelium: An old problem in a new era. Retina 27(5):523–533PubMedCrossRefGoogle Scholar
  11. 11.
    Cunningham ET Jr, Feiner L, Chung C et al (2011) Incidence of retinal pigment epithelial tears after intravitreal ranibizumab injection for neovascular age-related macular degeneration. Ophthalmology 118(12):2447–2452PubMedCrossRefGoogle Scholar
  12. 12.
    Karadimas P, Paleokastritis GP, Bouzas EA (2006) Fundus autofluorescence imaging findings in retinal pigment epithelial tear. Eur J Ophthalmol 16(5):767–769PubMedGoogle Scholar
  13. 13.
    von Ruckmann A, Fitzke FW, Bird AC (1995) Distribution of fundus autofluorescence with a scanning laser ophalmoscope. Br J Ophthalmol 79:407–412CrossRefGoogle Scholar
  14. 14.
    Delori FC, Dorey CK, Staurenhi G et al (1995) In vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristics. Invest Ophthalmol Vis Sci 36(3):718–729PubMedGoogle Scholar
  15. 15.
    Schmitz-Valckenberg S, Fleckenstein M, Scholl HP, Holtz FG (2009) Fundus autofluorescence and progression of age-related macular degeneration. Surv Ophthalmol 54(1):96–117PubMedCrossRefGoogle Scholar
  16. 16.
    Caramoy A, Kirchhof B, Fauser S (2011) Retinal pigment epithelium tears secondary to age-related macular degeneration. Arch Ophthalmol 129(5):575–579PubMedCrossRefGoogle Scholar
  17. 17.
    Peiretti E, Iranmanesh R, Lee JJ et al (2006) Repopulation of the retinal pigment epithelium after pigment epithelial rip. Retina 26(9):1097–1099PubMedCrossRefGoogle Scholar
  18. 18.
    Chuang EL, Bird AC (1998) Repair after tears of the retinal pigment epithelium. Eye 2:106–113CrossRefGoogle Scholar
  19. 19.
    Leonard DS, Zhang XG, Panozzo G et al (1997) Clinicopathological correlation of localized retinal pigment epithelium debridement. Invest Ophthalmol Vis Sci 38:1094–1109PubMedGoogle Scholar
  20. 20.
    Wang H, Ninomiya Y, Sugino IK, Zarbin MA (2003) Retinal pigment epithelium wound healing in human Bruch’s membrane explants. Invest Ophthalmol Vis Sci 44:2199–2210PubMedCrossRefGoogle Scholar
  21. 21.
    Del Priore LV, Kuo YH, Tezel TH (2002) Age related changes in human RPE cell density and apoptosis propotion in situ. Invest Ophthalmol Vis Sci 43(10):3312–3318PubMedGoogle Scholar
  22. 22.
    Caramy A, Fauser S, Kirchhof B (2012) Fundus autofluorescence and spectral domain optical coherence tomography findings suggesting tissue remodelling in retinal pigment epithelium tear. Br J Ophthalmol 96:1211–1216CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of OphthalmologyGrampian University Hospitals–NHS Trust, AberdeenAberdeenUK
  2. 2.Centre for Vascular and Visual SciencesQueens UniversityBelfastUK
  3. 3.Department of Ophthalmology, ACT Government HealthThe Canberra HospitalCanberraAustralia

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