High HbA1c level was the most important factor associated with prevalence of diabetic retinopathy in Taiwanese type II diabetic patients with a fixed duration

  • Shwu-Jiuan Sheu
  • Ni-Chun Liu
  • Lu-Ping Ger
  • Wan-Ling Ho
  • Jiun-Yo Lin
  • Shih-Chou Chen
  • Yu-Harn Horng
  • Hing-Chung Lam
Retinal Disorders



To identify the prevalence and related risk factors for diabetic retinopathy (DR) in non-insulin dependent diabetes in Taiwan.


A retrospective review of type II diabetic patients in the Diabetes Shared Care System database of our Hospital enrolled from 2002 to 2009. A retinopathy severity score was assigned according to fundus examination by indirect ophthalmoscopy or binocular biomicroscopy.


Data was collected on 901 subjects, 497 males and 404 females. Of these, 230 (25.53 %) had DR at enrolment. Compared with patients without DR, those with DR were more likely to be female (p = 0.03) or have higher HbA1c (p < 0.001), longer duration of diabetes (p < 0.001), hypertension (p < 0.001), higher systolic blood pressure (p < 0.001), higher diastolic blood pressure (p = 0.05), as well as impaired renal function (p = 0.001). In subgroup analysis stratified by diabetes duration, HbA1c was the most consistent independent risk factor associated to the prevalence of DR. Higher systolic blood pressure and female sex were significantly independent risk factors only in patients with a duration of diabetes < 4 years. On the contrary, old onset age showed a protective effect against DR only in those with a disease duration > 8 years.


High HbA1c level was the most important factor associated with prevalence of DR in Taiwanese type II DM patients with a fixed duration.


Diabetes HbA1c Prevalence Retinopathy Risk factor 



Supported in part by grant NSC97-2314-B-075B-011 from the National Science Council and grant VGHKS100-065 from the Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan. We thank the statistical assistance from Huey-Shyan Lin PhD.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Shwu-Jiuan Sheu
    • 1
    • 2
  • Ni-Chun Liu
    • 1
  • Lu-Ping Ger
    • 3
  • Wan-Ling Ho
    • 1
    • 4
  • Jiun-Yo Lin
    • 1
  • Shih-Chou Chen
    • 1
  • Yu-Harn Horng
    • 1
  • Hing-Chung Lam
    • 5
  1. 1.Department of OphthalmologyKaohsiung Veterans General HospitalKaohsiungTaiwan
  2. 2.School of MedicineNational Yang-Ming UniversityTaipeiTaiwan
  3. 3.Department of Research and EducationKaohsiung Veterans General HospitalKaohsiungTaiwan
  4. 4.Graduate School of Dental HealthKaohsiung Medical UniversityKaohsiungTaiwan
  5. 5.Department of EndocrinologyKaohsiung Veterans General HospitalKaohsiungTaiwan

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