High HbA1c level was the most important factor associated with prevalence of diabetic retinopathy in Taiwanese type II diabetic patients with a fixed duration
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To identify the prevalence and related risk factors for diabetic retinopathy (DR) in non-insulin dependent diabetes in Taiwan.
A retrospective review of type II diabetic patients in the Diabetes Shared Care System database of our Hospital enrolled from 2002 to 2009. A retinopathy severity score was assigned according to fundus examination by indirect ophthalmoscopy or binocular biomicroscopy.
Data was collected on 901 subjects, 497 males and 404 females. Of these, 230 (25.53 %) had DR at enrolment. Compared with patients without DR, those with DR were more likely to be female (p = 0.03) or have higher HbA1c (p < 0.001), longer duration of diabetes (p < 0.001), hypertension (p < 0.001), higher systolic blood pressure (p < 0.001), higher diastolic blood pressure (p = 0.05), as well as impaired renal function (p = 0.001). In subgroup analysis stratified by diabetes duration, HbA1c was the most consistent independent risk factor associated to the prevalence of DR. Higher systolic blood pressure and female sex were significantly independent risk factors only in patients with a duration of diabetes < 4 years. On the contrary, old onset age showed a protective effect against DR only in those with a disease duration > 8 years.
High HbA1c level was the most important factor associated with prevalence of DR in Taiwanese type II DM patients with a fixed duration.
KeywordsDiabetes HbA1c Prevalence Retinopathy Risk factor
Supported in part by grant NSC97-2314-B-075B-011 from the National Science Council and grant VGHKS100-065 from the Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan. We thank the statistical assistance from Huey-Shyan Lin PhD.
- 2.Tai TY, Yang CL, Chang CJ, Chang SM, Chen YH, Lin BJ, Ko LS, Chen MS, Chen CJ (1987) Epidemiology of diabetes mellitus among adults in Taiwan, R.O.C. J Med Assoc Taiwan 70:42–48Google Scholar
- 14.American Diabetes Association (2007) Summary of revisions for the 2007 clinical practice recommendations. Diabet Care 30(suppl 1):S3Google Scholar
- 15.Tung TH, Chou P, Tsai ST, Chen SJ, Lee FL, Tsai CY, Woung LC, Shih HC, Liu JH (2005) The epidemiology and economic evaluation of diabetic retinopathy among type 2 diabetes. Acta Taiwan Ophthalmol 44:277–290Google Scholar
- 18.Park CY, Park SE, Bae JC, Kim WJ, Park SW, Ha MM, Song SJ (2012) Prevalence of and risk factors for diabetic retinopathy in Koreans with type II diabetes: baseline characteristics of Seoul Metropolitan City-Diabetes Prevention Program (SMC-DPP) participants. Br J Ophthalmol 96:151–155PubMedCrossRefGoogle Scholar
- 29.Kelin R, Davis MD, Moss SE, Klein BE, DeMets DL (1985) The Wisconsin Epidemiologic Study of Diabetic Retinopathy: a comparison of retinopathy in younger and older onset diabetic persons. Adv Exp Med Biol 189:321–335Google Scholar
- 32.Kawasaki R, Tanaka S, Tanaka S, Yamamoto T, Sone H, Ohashi Y, Akanuma Y, Yamada N, Yamashita H, on behalf of the Japan Diabetic Complications Study Group (2011) Incidence and progression of diabetic retinopathy in Japanese adults with type 2 diabetes: 8 year follow-up study of the Japan Diabetes Complications Study (JDCS). Diabetologia 54:228–2294CrossRefGoogle Scholar