Comparison of corneal sensitivity between FS-LASIK and femtosecond lenticule extraction (ReLEx flex) or small-incision lenticule extraction (ReLEx smile) for myopic eyes

  • Shengsheng Wei
  • Yan WangEmail author
Refractive Surgery



To compare the effect on corneal sensitivity between femtosecond laser-assisted laser in situ keratomileusis (FS-LASIK) and femtosecond lenticule extraction (ReLEx flex) or FS-LASIK and small-incision lenticule extraction (ReLEx smile) surgery.


Twenty-seven subjects (54 eyes) underwent FS-LASIK, 22 subjects (40 eyes) underwent ReLEx flex, and 32 subjects (61 eyes) underwent ReLEx smile surgery. Cochet-Bonnet esthesiometry (Luneau Ophthalmologie Chartres, Cedex, France) was used to evaluate corneal sensitivity preoperatively as well as at 1 week and 1 and 3 months after surgery.


At 1 week, central, superior, nasal, and temporal corneal sensitivity in the ReLEx flex group was significantly higher than in the FS-LASIK group (P = 0.007, 0.004, 0.020, 0.004 respectively) and in the central and inferior areas at 3 months (P = 0.002, 0.009 respectively). A higher corneal sensitivity after ReLEx smile surgery was observed in every quadrant at 1 week and 1 and 3 months compared with FS-LASIK surgery (P < 0.01). Furthermore, in the ReLEx smile group, there were no statistical differences in the superior and temporal quadrants at 1 month postoperatively compared with preoperatively (5.19 ± 0.61 cm, P = 0.198 and 5.64 ± 0.48 cm, P = 0.330 respectively) and no significant differences in any quadrant at 3 months.


Postoperative corneal sensitivity was not remarkably changed after ReLEx smile surgery compared with FS-LASIK. This might be because ReLEx is a flapless procedure.


Corneal sensitivity Femtosecond laser Lenticule extraction Small incision 



The authors are grateful for the technical support of Tianjin Eye Hospital & Eye Institute, Tianjin Key Lab of Ophthalmology and Visual Science, and the financial support from the National Natural and Science Program Grant.

Conflicts of interest and source of funding

Neither author has a financial nor proprietary interest in any material or method mentioned. This work has received a National Natural and Science Program Grant (No. 81170873).


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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Tianjin Eye Hospital & Eye Institute, Tianjin Key Lab of Ophthalmology and Visual ScienceTianjin Medical UniversityTianjinChina

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