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Better performance of RTVue than Cirrus spectral-domain optical coherence tomography in detecting band atrophy of the optic nerve

  • Makoto NakamuraEmail author
  • Kumiko Ishikawa-Tabuchi
  • Akiyasu Kanamori
  • Yuko Yamada
  • Akira Negi
Neuro-ophthalmology

Abstract

Background

To assess the agreement and diagnostic performance between retinal nerve fiber layer (RNFL) thickness measurements obtained using the Cirrus (Carl Zeiss Meditec) and RTVue (Optovue Inc.) devices for detection of band atrophy (BA) in patients with permanent temporal hemianopia.

Methods

In this retrospective study, 26 eyes with BA and 64 control eyes were enrolled. The Cirrus optic disc cube protocol and the RTVue optic nerve head map protocol were used. The Cirrus measurements were extracted and regrouped to be topographically matched with the RTVue measurements. Concordance correlation and 95 % limits of agreement were assessed. Areas under the receiver operating characteristic curves (AUC) and the Spearman’s correlation coefficient between average Humphrey total deviation in the temporal hemifield and average RNFL thickness were calculated.

Results

RTVue measured consistently thicker values than Cirrus in controls, whereas in eyes with BA, nasal segment measurements from the RTVue were thinner than those obtained using the Cirrus. Each quadrant showed moderate to close agreement in controls, whereas in eyes with BA, the nasal and temporal quadrants exhibited poor agreement. The RTVue measurements demonstrated significantly higher AUCs for nasal segments just above (0.95) and below (0.96) the horizontal meridian than Cirrus measurements (0.80 and 0.66, respectively) and a significant correlation with visual field loss (rs = 0.46, P = 0.02 for RTVue vs. rs = 0.26, P = 0.22 for Cirrus).

Conclusions

The RTVue RNFL thickness measurements in nasal sectors showed better diagnostic performance in detecting BA and higher correlations with temporal hemianopia than the Cirrus measurements.

Keywords

Band atrophy Chiasmal compression Optical coherence tomography Retinal nerve fiber layer thickness Bitemporal hemianopia 

Notes

Acknowledgments

This study was supported in part by Grants-in-Aid 22390324 (A.N., Y.Y., M.N.) and 20592043 (M.N., A.N.) from the Ministry of Education, Culture, Sports, and Science and Technology of the Japanese government.

References

  1. 1.
    Unsold R, Hoyt WF (1980) Band atrophy of the optic nerve. The histology of temporal hemianopsia. Arch Ophthalmol 98(9):1637–1638PubMedCrossRefGoogle Scholar
  2. 2.
    Schuman JS, Hee MR, Arya AV, Pedut-Kloizman T, Puliafito CA, Fujimoto JG, Swanson EA (1995) Optical coherence tomography: a new tool for glaucoma diagnosis. Curr Opin Ophthalmol 6(2):89–95PubMedCrossRefGoogle Scholar
  3. 3.
    Kanamori A, Nakamura M, Matsui N, Nagai A, Nakanishi Y, Kusuhara S, Yamada Y, Negi A (2004) Optical coherence tomography detects characteristic retinal nerve fiber layer thickness corresponding to band atrophy of the optic discs. Ophthalmology 111(12):2278–2283PubMedCrossRefGoogle Scholar
  4. 4.
    Monteiro ML, Leal BC, Rosa AA, Bronstein MD (2004) Optical coherence tomography analysis of axonal loss in band atrophy of the optic nerve. Br J Ophthalmol 88(7):896–899PubMedCrossRefGoogle Scholar
  5. 5.
    Monteiro ML, Moura FC, Medeios FA (2007) Diagnostic ability of optical coherence tomography with a normative database to detect band atrophy of the optic nerve. Am J Ophthalmol 143(5):896–899PubMedCrossRefGoogle Scholar
  6. 6.
    Danesh-Meyer HV, Papchenko T, Savino PJ, Law A, Evans J, Gamble GD (2008) In vivo retinal nerve fiber layer thickness measured by optical coherence tomography predicts visual recovery after surgery for parachiasmal tumors. Investig Ophthalmol Vis Sci 49(5):1879–1885CrossRefGoogle Scholar
  7. 7.
    Danesh-Meyer HV, Carroll SC, Foroozan R, Savino PJ, Fan J, Jiang Y, Vander Hoorn S (2006) Relationship between retinal nerve fiber layer and visual field sensitivity as measured by optical coherence tomography in chiasmal compression. Investig Ophthalmol Vis Sci 47(11):4827–4835CrossRefGoogle Scholar
  8. 8.
    Monteiro ML, Cunha LP, Costa-cunha LV, Maia OO Jr, Oyamada MK (2009) Relationship between optical coherence tomography, pattern electroretinogram and automated perimetry in eyes with temporal hemianopia from chiasmal compression. Investig Ophthalmol Vis Sci 50(8):3535–3541CrossRefGoogle Scholar
  9. 9.
    Johansson C, Lindblom B (2009) The role of optical coherence tomography in the detection of pituitary adenoma. Acta Ophthalmol 87(7):776–779PubMedCrossRefGoogle Scholar
  10. 10.
    Sung KR, Kim DY, Park SB, Kook MS (2009) Comparison of retinal nerve fiber layer thickness measured by Cirrus HD and Stratus optical coherence tomography. Ophthalmology 116(7):1264–1270PubMedCrossRefGoogle Scholar
  11. 11.
    Lee ES, Kang SY, Choi EH, Kim JH, Kim NR, Seong GJ, Kim CY (2011) Comparisons of nerve fiber layer thickness measurements between Stratus, Cirrus, and RTVue OCTs in healthy and glaucomatous eyes. Optom Vis Sci 88(6):751–758PubMedCrossRefGoogle Scholar
  12. 12.
    Costa-Cunha LV, Cunha LP, Malta RF, Monteiro ML (2009) Comparison of Fourier-domain and time-domain optical coherence tomography in the detection of band atrophy of the optic nerve. Am J Ophthalmol 147(1):56–63PubMedCrossRefGoogle Scholar
  13. 13.
    Leite MT, Rao HL, Zangwill LM, Weinreb RN, Medeiros FA (2011) Comparison of the diagnostic accuracies of the Spectralis, Cirrus, RTVue optical coherence tomography devices in glaucoma. Ophthalmology 118(7):1334–1339PubMedGoogle Scholar
  14. 14.
    Monteriro ML, Costa-Cunha LV, Cunha LP, Malta RF (2010) Correlation between macular and retinal nerve fiber layer Fourier-domain OCT measurements and visual field loss in chiasmal compression. Eye 24(8):1382–1390CrossRefGoogle Scholar
  15. 15.
    Savini G, Carbonelli M, Barboni P (2010) Retinal nerve fiber layer thickness measurement by Fourier-domain optical coherence tomography: a comparison between cirrus-HD OCT and RTVue in healthy eyes. J Glaucoma 19(6):369–372PubMedCrossRefGoogle Scholar
  16. 16.
    Lin LI (1989) A concordance correlation coefficient to evaluate reproducibility. Biometrics 45(1):255–268PubMedCrossRefGoogle Scholar
  17. 17.
    Quinn C, Haber MJ, Pan Y (2009) Use of the concordance correlation coefficient when examining agreement in dyadic research. Nurs Res 58(1):368–373PubMedCrossRefGoogle Scholar
  18. 18.
    Bland JM, Altman DG (1986) Statistical methods for assessing agreement between two methods of clinical measurements. Lancet 1(8476):307–310PubMedCrossRefGoogle Scholar
  19. 19.
    DeLong ER, DeLong DM, Clarke-Pearson DL (1988) Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 44(3):837–845PubMedCrossRefGoogle Scholar
  20. 20.
    Watson GM, Keltner JL, Chin EK, Harvey D, Nguyen A, Park SS (2011) Comparison of retinal nerve fiber layer and central macular thickness measurements among five different optical coherence tomography instruments in patients with multiple sclerosis and optic neuritis. J Neuro-ophthalmol 31(2):110–116CrossRefGoogle Scholar
  21. 21.
    Leite MT, Rao HL, Weinreb RN, Zangwill AM, Bowd C, Sample CA, Tafreshi A, Medeiros FA (2011) Agreement among spectral-domain optical coherence tomography instruments for assessing retinal nerve fiber layer thickness. Am J Ophthalmol 151(1):85–92PubMedCrossRefGoogle Scholar
  22. 22.
    Knighton RW, Qian C (2000) An optical model of th human retinal nerve fiber layer: implications of directional reflectance for variability of clinical measurements. J Glaucoma 9(1):56–62PubMedCrossRefGoogle Scholar
  23. 23.
    Paunescu LA, Schuman JS, Price LL, Stark PC, Beaton S, Ishikawa H, Wollstein G, Fujimoto JG (2004) Reproducibility of nerve fiber thickness, macular thickness, and optic nerve head measurements using Stratus OCT. Investig Ophthalmol Vis Sci 45(6):1716–1724CrossRefGoogle Scholar
  24. 24.
    Gabriele ML, Ishikawa H, Wollstein G, Bilonick RA, Townsend KA, Kagemann L, Wojtkowski M, Srinivasan VJ, Fujimoto JG, Duker JS, Schuman JS (2008) Optical coherence tomography scan circle location and mean retinal nerve fiber layer measurement variability. Investig Ophthalmol Vis Sci 49(6):2315–2321CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Makoto Nakamura
    • 1
    Email author
  • Kumiko Ishikawa-Tabuchi
    • 1
  • Akiyasu Kanamori
    • 1
  • Yuko Yamada
    • 1
  • Akira Negi
    • 1
  1. 1.Division of Ophthalmology, Department of SurgeryKobe University Graduate School of MedicineKobeJapan

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