Advertisement

Impact of high myopia on the performance of SD-OCT parameters to detect glaucoma

  • Takuhei ShojiEmail author
  • Yui Nagaoka
  • Hiroki Sato
  • Etsuo Chihara
Glaucoma

Abstract

Background

The aim was to evaluate the effects of high myopia on spectral-domain optical coherence tomography (SD-OCT) parameters, as well as on their ability to detect glaucoma.

Methods

Ninety-three glaucoma and 86 non-glaucoma patients were divided into highly myopic group (HMG; 90 subjects, ≤ −5 diopters [D]) and emmetropic (EG; 89 subjects, spherical equivalent ≤1 D and ≥ −1D) groups in this cross-sectional comparative study. Macular ganglion cell complex (GCC) and circumpapillary retinal nerve fiber layer (cpRNFL) measurements obtained from the algorithms of the SD-OCT system were compared. The effects of refractive errors and glaucoma were assessed using a generalized linear model, after adjusting for age. A receiver operating characteristic curve was constructed for each parameter, and the areas under the curves (AUCs) were compared.

Results

The all cpRNFL measurements were significantly related to both refractive errors and glaucoma, while all GCC parameters were not significantly related to the refractive errors. The AUC for average GCC thickness was similar between the HMG (AUC, 0.935) and EG (AUC, 0.933), while the AUC for average cpRNFL thickness differed significantly (p = 0.028) between the HMG (AUC, 0.827) and EG (AUC, 0.939).

Conclusions

Macular GCC parameters showed good ability to detect glaucoma in both groups, whereas the ability of cpRNFL measurement in HMG subjects was inferior to that in EG subjects. Assessment of GCC parameters is a useful technique complementary to cpRNFL thickness assessment, for clinically evaluating patients with concomitant glaucoma and high myopia.

Keywords

Optical coherence tomography High myopia Glaucoma Ganglion cell complex 

Notes

Acknowledgments

Funding/support and financial disclosures

The authors received no financial support, and declare that they have no financial conflicts of interest.

Contributions of authors

Designing and conducting the study (T.S., E.C.); collection, management, analysis, and interpretation of data (T.S., Y.N., H.S., E.C.); preparation of manuscript (T.S.); and review and approval of the manuscript (H.S., E.C.).

Conflicts of interest

The authors have no proprietary interest in any aspect of this study. The authors report no conflicts of interest.

References

  1. 1.
    Mitchell P, Hourihan F, Sandbach J, Wang JJ (1999) The relationship between glaucoma and myopia: the Blue Mountains Eye Study. Ophthalmology 106:2010–2015PubMedCrossRefGoogle Scholar
  2. 2.
    Suzuki Y, Iwase A, Araie M, Yamamoto T, Abe H, Shirato S, Kuwayama Y, Mishima HK, Shimizu H, Tomita G, Inoue Y, Kitazawa Y (2006) Risk factors for open-angle glaucoma in a Japanese population: the Tajimi Study. Ophthalmology 113:1613–1617PubMedCrossRefGoogle Scholar
  3. 3.
    Chihara E, Liu X, Dong J, Takashima Y, Akimoto M, Hangai M, Kuriyama S, Tanihara H, Hosoda M, Tsukahara S (1997) Severe myopia as a risk factor for progressive visual field loss in primary open-angle glaucoma. Ophthalmologica 211:66–71PubMedCrossRefGoogle Scholar
  4. 4.
    Chihara E, Honda Y (1992) Preservation of nerve fiber layer by retinal vessels in glaucoma. Ophthalmology 99:208–214PubMedGoogle Scholar
  5. 5.
    Chihara E, Honda Y (1992) Multiple defects in the retinal nerve fiber layer in glaucoma. Graefes Arch Clin Exp Ophthalmol 230:201–205PubMedCrossRefGoogle Scholar
  6. 6.
    Leitgeb R, Hitzenberger C, Fercher A (2003) Performance of fourier domain vs. time domain optical coherence tomography. Opt Express 11:889–894PubMedCrossRefGoogle Scholar
  7. 7.
    Chen TC, Cense B, Pierce MC, Nassif N, Park BH, Yun SH, White BR, Bouma BE, Tearney GJ, de Boer JF (2005) Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging. Arch Ophthalmol 123:1715–1720PubMedCrossRefGoogle Scholar
  8. 8.
    Shoji T, Sato H, Ishida M, Takeuchi M, Chihara E (2011) Assessment of glaucomatous changes in subjects with high myopia using spectral domain optical coherence tomography. Invest Ophthalmol Vis Sci 52:1098–1102PubMedCrossRefGoogle Scholar
  9. 9.
    Kim NR, Lee ES, Seong GJ, Kang SY, Kim JH, Hong S, Kim CY (2011) Comparing the ganglion cell complex and retinal nerve fibre layer measurements by fourier domain OCT to detect glaucoma in high myopia. Br J Ophthalmol 95:1115–1121PubMedCrossRefGoogle Scholar
  10. 10.
    Hoh ST, Lim MC, Seah SK, Lim AT, Chew SJ, Foster PJ, Aung T (2006) Peripapillary retinal nerve fiber layer thickness variations with myopia. Ophthalmology 113:773–777PubMedCrossRefGoogle Scholar
  11. 11.
    Leung CK, Mohamed S, Leung KS, Cheung CY, Chan SL, Cheng DK, Lee AK, Leung GY, Rao SK, Lam DS (2006) Retinal nerve fiber layer measurements in myopia: an optical coherence tomography study. Invest Ophthalmol Vis Sci 47:5171–5176PubMedCrossRefGoogle Scholar
  12. 12.
    Rauscher FM, Sekhon N, Feuer WJ, Budenz DL (2009) Myopia affects retinal nerve fiber layer measurements as determined by optical coherence tomography. J Glaucoma 18:501–505PubMedCrossRefGoogle Scholar
  13. 13.
    Kim MJ, Lee EJ, Kim TW (2010) Peripapillary retinal nerve fibre layer thickness profile in subjects with myopia measured using the Stratus optical coherence tomography. Br J Ophthalmol 94:115–120PubMedCrossRefGoogle Scholar
  14. 14.
    Kang SH, Hong SW, Im SK, Lee SH, Ahn MD (2010) Effect of myopia on the thickness of the retinal nerve fiber layer measured by Cirrus HD optical coherence tomography. Invest Ophthalmol Vis Sci 51:4075–4083PubMedCrossRefGoogle Scholar
  15. 15.
    Hirasawa H, Tomidokoro A, Araie M, Konno S, Saito H, Iwase A, Shirakashi M, Abe H, Ohkubo S, Sugiyama K, Ootani T, Kishi S, Matsushita K, Maeda N, Hangai M, Yoshimura N (2010) Peripapillary retinal nerve fiber layer thickness determined by spectral-domain optical coherence tomography in ophthalmologically normal eyes. Arch Ophthalmol 128:1420–1426PubMedCrossRefGoogle Scholar
  16. 16.
    Tan O, Chopra V, Lu AT, Schuman JS, Ishikawa H, Wollstein G, Varma R, Huang D (2009) Detection of macular ganglion cell loss in glaucoma by fourier-domain optical coherence tomography. Ophthalmology 116:2305–2314PubMedCrossRefGoogle Scholar
  17. 17.
    Hanley JA, McNeil BJ (1982) The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology 143:29–36PubMedGoogle Scholar
  18. 18.
    Tong L, Chan YH, Gazzard G, Loon SC, Fong A, Selvaraj P, Healey PR, Tan D, Wong TY, Saw SM (2007) Heidelberg retinal tomography of optic disc and nerve fiber layer in singapore children: variations with disc tilt and refractive error. Invest Ophthalmol Vis Sci 48:4939–4944PubMedCrossRefGoogle Scholar
  19. 19.
    Leung CK, Cheng AC, Chong KK, Leung KS, Mohamed S, Lau CS, Cheung CY, Chu GC, Lai RY, Pang CC, Lam DS (2007) Optic disc measurements in myopia with optical coherence tomography and confocal scanning laser ophthalmoscopy. Invest Ophthalmol Vis Sci 48:3178–3183PubMedCrossRefGoogle Scholar
  20. 20.
    Varma R, Skaf M, Barron E (1996) Retinal nerve fiber layer thickness in normal human eyes. Ophthalmology 103:2114–2119PubMedGoogle Scholar
  21. 21.
    Qiu KL, Zhang MZ, Leung CK, Zhang RP, Lu XH, Wang G, Lam DS (2011) Diagnostic classification of retinal nerve fiber layer measurement in myopic eyes: a comparison between time-domain and spectral-domain optical coherence tomography. Am J Ophthalmol 152:646–653PubMedCrossRefGoogle Scholar
  22. 22.
    Rao HL, Kumar AU, Babu JG, Kumar A, Senthil S, Garudadri CS (2011) Predictors of normal optic nerve head, retinal nerve fiber layer, and macular parameters measured by spectral domain optical coherence tomography. Invest Ophthalmol Vis Sci 52:1103–1110PubMedCrossRefGoogle Scholar
  23. 23.
    Seong M, Sung KR, Choi EH, Kang SY, Cho JW, Um TW, Kim YJ, Park SB, Hong HE, Kook MS (2010) Macular and peripapillary retinal nerve fiber layer measurements by spectral domain optical coherence tomography in normal-tension glaucoma. Invest Ophthalmol Vis Sci 51:1446–1452PubMedCrossRefGoogle Scholar
  24. 24.
    Medeiros FA, Ng D, Zangwill LM, Sample PA, Bowd C, Weinreb RN (2007) The effects of study design and spectrum bias on the evaluation of diagnostic accuracy of confocal scanning laser ophthalmoscopy in glaucoma. Invest Ophthalmol Vis Sci 48:214–222PubMedCrossRefGoogle Scholar
  25. 25.
    Gonzalez-Garcia AO, Vizzeri G, Bowd C, Medeiros FA, Zangwill LM, Weinreb RN (2009) Reproducibility of RTVue retinal nerve fiber layer thickness and optic disc measurements and agreement with Stratus optical coherence tomography measurements. Am J Ophthalmol 147:1067–1074PubMedCrossRefGoogle Scholar
  26. 26.
    Garas A, Vargha P, Hollo G (2010) Reproducibility of retinal nerve fiber layer and macular thickness measurement with the RTVue-100 optical coherence tomograph. Ophthalmology 117:738–746PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Takuhei Shoji
    • 1
    • 4
    Email author
  • Yui Nagaoka
    • 2
  • Hiroki Sato
    • 3
  • Etsuo Chihara
    • 2
  1. 1.Department of OphthalmologyYukisada HospitalKawagoeJapan
  2. 2.Sensho-kai Eye InstituteUjiJapan
  3. 3.Department of Medical InformaticsNational Defense Medical College HospitalTokorozawaJapan
  4. 4.Department of OphthalmologyNational Defense Medical CollegeTokorozawaJapan

Personalised recommendations