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Restoration of the photoreceptor layer and improvement of visual acuity in successfully treated optic disc pit maculopathy: a long follow-up study by optical coherence tomography

  • George P. Theodossiadis
  • Vlassis G. Grigoropoulos
  • Vasilis S. Liarakos
  • Alexandros Rouvas
  • Ioannis Emfietzoglou
  • Panagiotis G. Theodossiadis
Retinal Disorders

Abstract

Purpose

To investigate by optical coherence tomography (OCT) the evolution of the photoreceptor layer and its association with best-corrected visual acuity (BCVA) in optic disc pit (ODP) maculopathy after successful surgical treatment.

Methods

Fourteen eyes of 14 patients were included in this study, and followed up from 36 to 95 months (mean 57.36 ± 18.32 months). The follow-up period started at the time of complete subretinal fluid absorption. Examination was performed by time-domain OCT before and after treatment. Spectral-domain OCT was used after treatment. Parameters assessed were type of elevation, central foveal thickness, time elapsed from onset to treatment, type of treatment, BCVA, and inner segment outer segment (IS/OS) junction line. The IS/OS junction was characterized after treatment as intact, interrupted, or absent (not distinguishable).

Results

Significant restoration of the IS/OS junction line was first noticed between 6 and 12 months after fluid absorption (p = 0.02; Wilcoxon signed rank test). Restoration was continuous up to the 24th month of postoperative examination after fluid absorption (p = 0.14; Wilcoxon signed rank test). BCVA was 0.99 ± 0.38 logMar before treatment, 0.81 ± 0.26 logMar (p = 0.011; paired t-test) immediately after fluid absorption and 0.61 ± 0.33 logMar (p = 0.026; one-way ANOVA) 24 months after fluid resolution. BCVA was significantly positively correlated with the integrity of the IS/OS junction line during follow-up (Pearson r = 0.775; p < 0.001).

Conclusions

The IS/OS junction restoration cannot be detected immediately after fluid resolution in the majority of cases. It became evident 6–12 months later and was completed 24 months after fluid absorption. Improvement in BCVA was noticed only during the first 2 years of follow-up. No significant changes were noticed in BCVA or the IS/OS line after 2 years. Among the studied variables, the final photoreceptor layer condition and BCVA immediately after fluid absorption are the main factors predicting final BCVA after successful surgical treatment of ODP maculopathy.

Keywords

Optic disc pit maculopathy Inner outer segment junction line (IS/OS) Best-corrected visual acuity Optical coherence tomography 

Notes

Disclosure information

The above authors confirm that the manuscript with the above title submitted for consideration for publication in Graefe’s Archive for Clinical and Experimental Ophthalmology is not related with any proprietary or commercial interests. No sponsoring organizations have been involved, and no grants were received from any organization or institution.

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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • George P. Theodossiadis
    • 1
  • Vlassis G. Grigoropoulos
    • 1
  • Vasilis S. Liarakos
    • 2
  • Alexandros Rouvas
    • 2
  • Ioannis Emfietzoglou
    • 1
  • Panagiotis G. Theodossiadis
    • 2
  1. 1.2nd Department of OphthalmologyHenry Dunant HospitalAthensGreece
  2. 2.2nd Department of OphthalmologyUniversity of AthensAthensGreece

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