Lack of association of VEGF gene 3’- UTR polymorphisms (C702T, C936T and G1612A) and the risk of developing advanced retinopathy of prematurity (ROP)

  • Daniela Gismondi
  • Livja Ndoja
  • Xianggui Qu
  • Barkur S. Shastry
Letter to the Editor

References

  1. 1.
    Shastry BS (2011) Genetic risk in the development of advanced retinopathy of prematurity. CML Ophthalmol 21:89–96Google Scholar
  2. 2.
    Shastry BS (2010) Genetic susceptibility to advanced retinopathy of prematurity. J Biomed Sci 17:69–75PubMedCrossRefGoogle Scholar
  3. 3.
    Pierce EA, Foley ED, Smith LEH (1996) Regulation of Vascular endothelial growth factor by oxygen in a model of retinopathy of prematurity. Arch Ophthalmol 114:1219–1228PubMedCrossRefGoogle Scholar
  4. 4.
    Alon T, Hemo I, Itin A, Peer J, Stone J, Keshet E (1995) Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nat Med 1:1024–1028PubMedCrossRefGoogle Scholar
  5. 5.
    Vannay A, Dunai G, Banyasz I, Szabo M, Vamos R, Treszl A, Hajdu J, Tulassay T, Vasarhelyi B (2005) Association of genetic polymorphisms of vascular endothelial growth factor and risk for proliferative retinopathy of prematurity. Pediatr Res 57:396–398PubMedCrossRefGoogle Scholar
  6. 6.
    Dunai G, Vasarhelyi B, Szabo M, Hajdu J, Meszaros G, Tulassay T, Treszl A (2008) Published genetic variants in retinopathy of prematurity: random forest analysis suggests a negligible contribution to risk and severity. Curr Eye Res 33:501–505PubMedCrossRefGoogle Scholar
  7. 7.
    Renner W, Kotschan S, Hoffmann C, Obermayer-Pietsch B, Pilger E (2000) A common 936 C/T mutation in the gene for vascular endothelial growth factor is associated with vascular endothelial growth factor plasma levels. J Vas Res 37:443–448CrossRefGoogle Scholar
  8. 8.
    Abe A, Sato K, Habuchi T, Wang L, Li Z, Tsuchiya N, Ohyama C, Satoh S, Ogawa S, Kato T (2002) Single nucleotide polymorphisms in the 3’- untranslated region of vascular endothelial growth factor gene in Japanese population with or without renal cell carcinoma. Tohoku J Exp Med 198:181–190PubMedCrossRefGoogle Scholar
  9. 9.
    Cooke RW, Drury JAQ, Mountford R, Clark D (2004) Genetic polymorphisms and retinopathy of prematurity. Invest Ophthalmol Vis Sci 45:1712–1715PubMedCrossRefGoogle Scholar
  10. 10.
    Kusuda T, Hikino S, Ohga S, Kinjo T, Ochiai M, Takahata Y, Tokunaga S, Ihara K, Hata Y, Hara T (2011) Genetic variation of vascular endothelial growth factor pathway does not correlate with the severity of retinopathy of prematurity. J Perinatol 31:246–250PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Daniela Gismondi
    • 1
  • Livja Ndoja
    • 1
  • Xianggui Qu
    • 2
  • Barkur S. Shastry
    • 1
  1. 1.Department of Biological SciencesOakland UniversityRochesterUSA
  2. 2.Department of Mathematics and StatisticsOakland UniversityRochesterUSA

Personalised recommendations