Topical application of autologous adipose-derived mesenchymal stem cells (MSCs) for persistent sterile corneal epithelial defect

  • George I. Agorogiannis
  • Vassilia-Ismini Alexaki
  • Ourania Castana
  • George D. Kymionis
Case Report


  1. 1.
    Centeno CJ, Busse D, Kisiday J, Keohan C, Freeman M, Karli D (2008) Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells. Pain Physician 11:343–353PubMedGoogle Scholar
  2. 2.
    Arnalich-Montiel F, Pastor S, Blazquez-Martinez A, Fernandez-Delgado J, Nistal M, Alio JL (2008) Adipose-derived stem cells are a source for cell therapy of the corneal stroma. Stem Cells 26:570–579PubMedCrossRefGoogle Scholar
  3. 3.
    Bunnell BA, Flaat M, Gaqliardi C, Patel B, Ripoll C (2008) Adipose-derived stem cells: isolation, expansion and differentiation. Methods 45:115–120PubMedCrossRefGoogle Scholar
  4. 4.
    Alexaki VI, Notas G, Pelekanou V, Kampa M, Valkanou M, Theodoropoulos P, Stathopoulos EN, Tsapis A, Castanas E (2009) Adipocytes as immune cells: differential expression of TWEAK, BAFF and APRIL and their receptors (Fn14, BAFF-R, TACI and BCMA) at different stages of normal and pathological adipose tissue development. J Immunol 183:5948–5956PubMedCrossRefGoogle Scholar
  5. 5.
    Daher SR, Johnstone BH, Phinney DG, March KL (2008) Adipose stromal/stem cells: basic and translational advances: the IFATS collection. Stem Cells 26:2664–2665PubMedCrossRefGoogle Scholar
  6. 6.
    Uccelli A, Moretta L, Pistoia V (2008) Mesenchymal stem cells in health and disease. Nat Rev Immunol 8:726–736PubMedCrossRefGoogle Scholar
  7. 7.
    Phinney DG, Prockop DJ (2007) Mesenchymal stem/multi-potent stromal cells (MSCs): the state of transdifferentiation and modes of tissue repair — current views. Stem Cells 25:2896–2902PubMedCrossRefGoogle Scholar
  8. 8.
    Körbling M, Estrov Z (2003) Adult stem cells for tissue repair — a new therapeutic concept? N Engl J Med 349:570–582PubMedCrossRefGoogle Scholar
  9. 9.
    Quarto R, Mastrogiacomo M, Cancedda R, Kutepov SM, Mukhachev V, Lavroukov A, Kon E, Marcacci M (2001) Repair of large bone defects with the use of autologous bone marrow stromal cells. N Engl J Med 344:385–386PubMedCrossRefGoogle Scholar
  10. 10.
    Meirelles Lda S, Fontes AM, Covas DT, Caplan AI (2009) Mechanisms involved in the therapeutic properties of mesenchymal stem cells. Cytokine Growth Factor Rev 20:419–427PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • George I. Agorogiannis
    • 1
  • Vassilia-Ismini Alexaki
    • 2
  • Ourania Castana
    • 3
  • George D. Kymionis
    • 1
    • 4
  1. 1.Eye ClinicUniversity Hospital of Heraklion, CreteHeraklionGreece
  2. 2.Laboratory of Experimental EndocrinologyUniversity of Crete, School of MedicineHeraklionGreece
  3. 3.Department of Plastic and Reconstructive SurgeryEvangelismos General HospitalAthensGreece
  4. 4.University of Crete, School of Medicine, Department of OphthalmologyUniversity Hospital of CreteHeraklionGreece

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