Topical application of autologous adipose-derived mesenchymal stem cells (MSCs) for persistent sterile corneal epithelial defect
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Different causes of corneal persistent epithelial defects (PED) have been described including dry eye, corneal epithelial stem cell deficiency, diabetes mellitus, and neurotrophic keratopathy (after herpetic keratitis or corneal surgery). Corneal PEDs could lead to a cascade of events throughout the cornea, resulting in stromal degradation, thinning and in advanced cases, corneal perforation.
Several treatment options have been proposed for corneal PEDs (based on the etiology) such as eye patching, unpreserved artificial tears, bandage contact lens, punctual plugging, tarsorrhaphy, autologous serum eyedrops, limbal stem cells transplantation, and amniotic membrane grafting.
Mesenchymal stem cells (MSCs) are multipotent stem cells that can differentiate into a variety of cell types. Clinical uses of these cells have been proposed, such as in patients with degenerative joint disease (using percutaneously implanted autologous MSCs) , while adipose-derived MSCs have been...
KeywordsCentral Corneal Thickness Keratoconus Corrected Distance Visual Acuity Corneal Perforation Corneal Epithelial Defect
We thank the heads of the Ophthalmology and Experimental Endocrinology departments (University of Crete, School of Medicine, Heraklion, Greece), Professors Ioannis G Pallikaris and Elias Castanas, for their constant support and fruitful discussions, which stimulated the current study.
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