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Comparative study of vitrectomy versus intravitreous triamcinolone for diabetic macular edema on randomized paired-eyes

  • Norihito Doi
  • Taiji SakamotoEmail author
  • Yasushi Sonoda
  • Miho Yasuda
  • Koji Yonemoto
  • Noboru Arimura
  • Eisuke Uchino
  • Tatsuro Ishibashi
Retinal Disorders

Abstract

Background

The present study was performed to compare the effects of pars plana vitrectomy (PPV) and single intravitreaous triamcinolone acetonide (IVTA) on diabetic macular edema (DME) in paired eyes.

Methods

Prospective comparative study on randomized paired-eyes was carried out at two hospitals. Forty eyes of 20 patients with bilateral DME were included. One randomly-selected eye was treated with PPV (PPV group), and the other eye was treated with IVTA (4 mg, IVTA group). The central macular thickness (CMT) measured by optical coherence tomography (OCT) and best-corrected visual acuity (BCVA) were monitored for 12 months after treatment. Changes from baseline and differences between groups were analyzed using a mixed model.

Results

At 1 and 3 months, CMT decreased significantly in the IVTA group compared to baseline (p < 0.0001 both), but CMT then increased gradually and no significant difference was found at 12 months (p = 0.90). In the PPV group, CMT decreased continuously and reached a significant level at 12 months (p < 0.0001). CMT of the IVTA group was significantly less than that of the PPV group at 1 month (p = 0.009); however, there was no significant difference at 3 months. Conversely, CMT was significantly less in the PPV group than in the IVTA group at 12 months (p = 0.0003). The changes of BCVA paralleled those of CMT, but no significant difference was detected between baseline BCVA and any time point.

Conclusions

Despite the short-term improvement, DME recurred 6 months after IVTA, while it remained resolved after PPV. Although this study did not reveal a significant change of BCVA with either treatment, PPV resolved DME more effectively than IVTA at 1 year.

Keywords

Diabetic retinopathy Corticosteroid Central macular thickness Pars plana vitrectomy Pharmacologic therapy 

Notes

Acknowledgements

We appreciate the technical support by Drs Hiroki Otsuka, MD, and Toshifumi Yamashita, MD.

Grant support

Supported in part by a Grant from the Research Committee on Chorioretinal Degeneration and Optic Atrophy, Ministry of Health, Labor, and Welfare; by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, and Culture of the Japanese Government.

Conflict of interest

None.

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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Norihito Doi
    • 1
  • Taiji Sakamoto
    • 1
    Email author
  • Yasushi Sonoda
    • 1
  • Miho Yasuda
    • 2
  • Koji Yonemoto
    • 3
  • Noboru Arimura
    • 1
  • Eisuke Uchino
    • 1
  • Tatsuro Ishibashi
    • 2
  1. 1.Department of Ophthalmology Faculty of MedicineKagoshima University Graduate School of Medicine and Dental SciencesKagoshimaJapan
  2. 2.Kyushu University School of MedicineFukuokaJapan
  3. 3.Biostatics CenterKurume UniversityKurumeJapan

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