Reduced retinal blood flow-velocity in severe hyperlipidemia measured by the retinal function imager

  • Yael Birger
  • Oren Blumenfeld
  • Elisha Bartov
  • Zvia Burgansky-Eliash
Case Report


Severe hyperlipidemia is associated with rare ocular manifestations, including iris and retinal xanthomas, lipid keratopathy, and lipemia retinalis. The later condition of lipemic discolorization of the retinal vessels and fundus has rarely been described in cases of severe hypertriglyceridemia [1]. We report here a case of a patient with lipemia retinalis where retinal blood flow velocity was measured in the acute phase and after a reduction in triglyceride level was achieved.

Materials and method

A 43-year-old Caucasian male was admitted to the hospital due to new-onset diabetes mellitus, with blood glucose levels of 507 mg/dl. The patient's father died from chronic heart failure at the age of 81 years, and both his mother and sister suffer from dyslipidemia of unknown nature with no evidence of thrombo-embolic complications. Past history included hypertension and obstructive sleep apnea syndrome. Blood pressure was 135/81 mmHg and mean arterial pressure [MAP = diastolic...


Obstructive Sleep Apnea Diabetic Retinopathy Obstructive Sleep Apnea Syndrome Repaglinide Bezafibrate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors thank Hila Barash for her assistance with RFI imaging and analysis.


  1. 1.
    Rayner S, Lee N, Leslie D, Thompson G (1996) Lipaemia retinalis: A question of chylomicrons? Eye (Lond) 10(Pt 5):603–608CrossRefGoogle Scholar
  2. 2.
    Burgansky-Eliash Z, Nelson DA, Bar-Tal OP et al (2010) Reduced retinal blood flow velocity in diabetic retinopathy. Retina 30:765–773PubMedCrossRefGoogle Scholar
  3. 3.
    Lu CK, Chen SJ, Niu DM, Tsai CC, Lee FL, Hsu WM (2005) Electrophysiological changes in lipaemia retinalis. Am J Ophthalmol 139:1142–1145PubMedCrossRefGoogle Scholar
  4. 4.
    Burgansky-Eliash Z, Barak A, Barash H et al (2011) Increased retinal blood-flow velocity in patients with early diabetes. Retina [In press]Google Scholar
  5. 5.
    Giannattasio C, Zoppo A, Gentile G, Failla M, Capra A, Maggi FM, Catapano A, Mancia G (2005) Acute effect of high-fat meal on endothelial function in moderately dyslipidemic subjects. Arterioscler Thromb Vasc Biol 25:406–410PubMedCrossRefGoogle Scholar
  6. 6.
    Polak K, Schmetterer L, Luksch A, Gruber S, Polska E, Peternell V, Bayerle-Eder M, Wolzt M, Krebs M, Roden M (2001) Free fatty acids/triglycerides increase ocular and subcutaneous blood flow. Am J Physiol Regul Integr Comp Physiol 280:R56–R61PubMedGoogle Scholar
  7. 7.
    Bayerle-Eder M, Polska E, Kopf A, Roden M, Waldhausl W, Pleiner H, Wipler B, Wolzt M, Schmetterer L (2004) Free fatty acids exert a greater effect on ocular and skin blood flow than triglycerides in healthy subjects. Eur J Clin Investig 34:519–526CrossRefGoogle Scholar
  8. 8.
    Seplowitz AH, Chien S, Smith FR (1981) Effects of lipoproteins on plasma viscosity. Atherosclerosis 38:89–95PubMedCrossRefGoogle Scholar
  9. 9.
    Lee CY, Kim KC, Park HW, Song JH, Lee CH (2004) Rheological properties of erythrocytes from male hypercholesterolemia. Microvasc Res 67:133–138PubMedCrossRefGoogle Scholar
  10. 10.
    Cicha I, Suzuki Y, Tateishi N, Maeda N (2004) Effects of dietary triglycerides on rheological properties of human red blood cells (abstract). Clin Hemorheol Microcirc 30:301–305PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Yael Birger
    • 1
  • Oren Blumenfeld
    • 1
  • Elisha Bartov
    • 1
  • Zvia Burgansky-Eliash
    • 1
  1. 1.Department of Ophthalmology, The Edith Wolfson Medical CenterThe Sackler School of MedicineHolonIsrael

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