Vitrectomy does not increase the risk of open-angle glaucoma or ocular hypertension—a 5-year follow-up

  • Alice L. Yu
  • Wolfgang Brummeisl
  • Markus Schaumberger
  • Anselm Kampik
  • Ulrich Welge-LussenEmail author
Retinal Disorders



The goal of this study was to investigate the development of late onset open-angle glaucoma (OAG) or ocular hypertension after vitrectomy in phakic and pseudophakic eyes.


In this retrospective case series, the records of 441 patients who had undergone vitrectomy in one eye by a single surgeon were reviewed. The development of OAG or ocular hypertension in the vitrectomized and fellow control eyes was compared. Furthermore, the influence of the lens status (phakic or pseudophakic) on the onset of OAG or ocular hypertension in the vitrectomized and fellow control eyes was analysed. Additionally, the mean intraocular pressure (IOP) and the mean number of antiglaucomatous medications were calculated for both eyes.


A mean follow-up period of 79.5 ± 25.6 months was achieved. There were 19 vitrectomized eyes (4.31%) with postoperative OAG, and 19 vitrectomized eyes (4.31%) with postoperative ocular hypertension. Eleven control eyes (2.49%) had OAG, and 13 control eyes (2.95%) ocular hypertension. There were no statistically significant differences in the development of OAG or ocular hypertension between the vitrectomized and fellow control eyes. Furthermore, the lens status in vitrectomized eyes did not influence the late development of OAG or ocular hypertension. There were no significant differences in the mean IOP and the mean number of antiglaucomatous medications between the two eyes.


Contrary to previous reports, we could not observe an increased incidence of late onset OAG or ocular hypertension after vitrectomy. Similarly, the removal of the lens did not increase the risk of OAG or ocular hypertension in vitrectomized eyes.


Vitrectomy Open-angle glaucoma Ocular hypertension Cataract Long-term 



The data in this study are part of the medical thesis of Wolfgang A. Brummeisl at the Medical School of the Ludwig-Maximilian University, Munich, Germany.


  1. 1.
    Fine HF, Iranmanesh R, Iturralde D, Spaide RF (2007) Outcomes of 77 consecutive cases of 23-gauge transconjunctival vitrectomy surgery for posterior segment disease. Ophthalmology 114:1197–1200CrossRefPubMedGoogle Scholar
  2. 2.
    Spirn MJ (2009) Comparison of 25, 23 and 20-gauge vitrectomy. Curr Opin Ophthalmol 20:195–199CrossRefPubMedGoogle Scholar
  3. 3.
    Chen CJ (1998) Glaucoma after macular hole surgery. Ophthalmology 105:94–100CrossRefPubMedGoogle Scholar
  4. 4.
    Costarides AP, Alabata P, Bergstrom C (2004) Elevated intraocular pressure following vitreoretinal surgery. Ophthalmol Clin North Am 17:507–512CrossRefPubMedGoogle Scholar
  5. 5.
    Tranos P, Bhar G, Little B (2004) Postoperative intraocular pressure spikes: the need to treat. Eye 18:673–679CrossRefPubMedGoogle Scholar
  6. 6.
    Han DP, Lewis H, Lambrou FH Jr, Mieler WF, Hartz A (1989) Mechanisms for intraocular pressure elevation after pars plana vitrectomy. Ophthalmology 96:1357–1362PubMedGoogle Scholar
  7. 7.
    Desai UR, Alhalel AA, Schiffman RM, Campen TJ, Sundar G, Muhich A (1997) Intraocular pressure elevation after simple pars plana vitrectomy. Ophthalmology 104:781–786PubMedGoogle Scholar
  8. 8.
    Gedde SJ (2002) Management of glaucoma after retinal detachment surgery. Curr Opin Ophthalmol 13:103–109CrossRefPubMedGoogle Scholar
  9. 9.
    Yamashita T, Uemura A, Kita H, Sakamoto T (2007) Intraocular pressure after intravitreal injection of triamcinolone acetonide following vitrectomy for macular edema. J Glaucoma 16:220–224CrossRefPubMedGoogle Scholar
  10. 10.
    Honavar SG, Goyal M, Majji AB, Sen PK, Naduvilath T, Dandona L (1999) Glaucoma after pars plana vitrectomy and silicone oil injection for complicated retinal detachments. Ophthalmology 106:169–177CrossRefPubMedGoogle Scholar
  11. 11.
    Van Aken E, Lemij H, Vander Haeghen Y, de Waard P (2008) Baerveldt glaucoma implants in the management of refractory glaucoma after vitreous surgery. Acta Ophthalmol 2010 88:75–79CrossRefGoogle Scholar
  12. 12.
    Perez RN, Phelps CD, Burton TC (1976) Angle-closure glaucoma following scleral buckling operations. Trans Am Acad Ophthalmol Otolaryngol 81:247–252Google Scholar
  13. 13.
    Chang S (2006) LXII Edward Jackson lecture: open angle glaucoma after vitrectomy. Am J Ophthalmol 141:1033–1043CrossRefPubMedGoogle Scholar
  14. 14.
    Luk FO, Kwok AK, Lai TY, Lam DS (2009) Presence of crystalline lens as a protective factor for the late development of open angle glaucoma after vitrectomy. Retina 29:218–224CrossRefPubMedGoogle Scholar
  15. 15.
    Magnusson G, Abrahamsson M, Sjöstrand J (2000) Glaucoma following congenital cataract surgery: an 18-year longitudinal follow-up. Acta Ophthalmol Scand 78:65–70CrossRefPubMedGoogle Scholar
  16. 16.
    Friedman DS, Jampel HD, Lubomski LH, Kempen JH, Quigley H, Congdon N, Leykovitch-Verbin H, Robinson KA, Bass EB (2002) Surgical strategies for coexisting glaucoma and cataract. An evidence-based update. Ophthalmology 109:1902–1913CrossRefPubMedGoogle Scholar
  17. 17.
    Hayashi K, Hayashi H, Nakao F, Hayashi F (2000) Changes in anterior chamber angle width and depth after intraocular lens implantation in eyes with glaucoma. Ophthalmology 107:698–703CrossRefPubMedGoogle Scholar
  18. 18.
    Perasalo R (1997) Phaco-emulsification of cataract in eyes with glaucoma. Acta Ophthalmol Scand 75:299–230CrossRefPubMedGoogle Scholar
  19. 19.
    Pohjalainen T, Vesti E, Uusitalo RJ, Laatikainen L (2001) Phacoemulsification and intraocular lens implantation in eyes with open-angle glaucoma. Acta Ophthalmol Scand 79:313–316CrossRefPubMedGoogle Scholar
  20. 20.
    Mathalone N, Hyams M, Nieman S, Buckman G, Hod Y, Geyer O (2005) Long-term intraocular pressure control after clear corneal phacoemulsification in glaucoma patients. J Cataract Refract Surg 31:479–483CrossRefPubMedGoogle Scholar
  21. 21.
    Shingleton BJ, Pasternack JJ, Hung JW, O’Donoghue MW (2006) Three and five year changes in intraocular pressures after clear corneal phacoemulsification in open angle glaucoma patients, glaucoma suspects, and normal patients. J Glaucoma 15:494–498CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Alice L. Yu
    • 1
  • Wolfgang Brummeisl
    • 1
  • Markus Schaumberger
    • 1
  • Anselm Kampik
    • 1
  • Ulrich Welge-Lussen
    • 2
    • 3
    Email author
  1. 1.Department of OphthalmologyLudwig-Maximilians-UniversityMunichGermany
  2. 2.Augenklinik der Friedrich-Alexander-UniversitätErlangenGermany
  3. 3.Department of OphthalmologyFriedrich-Alexander UniversityErlangenGermany

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