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Recurrent disc hemorrhage does not increase the rate of visual field progression

  • Heather C. de BeaufortEmail author
  • Carlos Gustavo V. De Moraes
  • Christopher C. Teng
  • Tiago S. Prata
  • Celso Tello
  • Robert Ritch
  • Jeffrey M. Liebmann
Glaucoma

Abstract

Aims

To determine whether recurrent disc hemorrhage (DH) accelerates glaucomatous visual field (VF) loss compared to an isolated, single, detected DH.

Methods

We evaluated the disc photographs of consecutive patients with ≥5 SITA-Standard fields for DH. Group A had patients with a single DH in one eye, and group B had at least one recurrence in the same eye. Automated pointwise linear regression analysis was used to calculate rates of progression. Logistic regression was used to determine ocular or systemic variables associated with DH recurrence after baseline assessment.

Results

One hundred and seventeen patients were enrolled (group A = 72, group B = 45). The mean age was 67.1 ± 10.8 years; most patients were women (65%) of European ancestry (92%) diagnosed with primary open-angle glaucoma (47%). The mean number of VF after the initial DH was 7.9 ± 2.9, spanning a mean of 4.6 ± 2.2 years. None of the ocular or systemic characteristics revealed a significant difference between groups. The mean global rate of progression (group A, −0.8 ± 0.6 vs group B, −0.8 ± 0.7 dB/year, p = 0.93) and number of eyes reaching a progression endpoint (group A, 70% vs group B, 73%, p = 0.80) did not differ between groups. Recurrent DH eyes showed a tendency to be followed longer, with a greater number of disc photographs, which was not significant in the multivariate analysis. The global rates of progression between groups remained non-significant even after adjusting to follow-up time and number of VF tests (p = 0.69).

Conclusion

Recurrent DH does not result in a faster rate of VF progression compared to a single detected DH. Eyes with single or recurrent DH have similar risks for future disease progression.

Keywords

Disc hemorrhage Recurrence Glaucoma Progression 

Notes

Funding/Acknowledgement

Supported by the Edith C. Blum Foundation, New York, NY and the New York Glaucoma Research Institute, NY, NY.

Financial disclosure

None

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Heather C. de Beaufort
    • 1
    • 4
    • 5
    Email author
  • Carlos Gustavo V. De Moraes
    • 1
    • 2
  • Christopher C. Teng
    • 1
    • 2
    • 3
  • Tiago S. Prata
    • 2
  • Celso Tello
    • 2
    • 3
  • Robert Ritch
    • 2
    • 3
  • Jeffrey M. Liebmann
    • 1
    • 2
    • 3
    • 4
  1. 1.OphthalmologyNew York University School of MedicineNew YorkUSA
  2. 2.Einhorn Clinical Research CenterNew York Eye and Ear InfirmaryNew YorkUSA
  3. 3.New York Medical CollegeValhallaUSA
  4. 4.Manhattan EyeEar and Throat HospitalNew YorkUSA
  5. 5.New YorkUSA

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