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Non-arteritic anterior ischemic optic neuropathy and thrombophilia

  • Sohan Singh HayrehEmail author
Editorial

Non-arteritic anterior ischemic optic neuropathy (NA-AION) is a common, visually disabling disorder occurring in the middle-aged and elderly, but no age group is immune to it—in two large series the youngest persons with NA-ION were 18 [1] and 13 [2] years old. NA-AION is a multifactorial disease; several risk factors play a role in its development, some acting as predisposing and others as precipitating risk factors, as discussed detail elsewhere [3, 4, 5, 6]. Some studies have mentioned thrombophilia [7, 8, 9, 10, 11, 12] as a risk factor, including one published in this issue of this journal [13]. To place the role of thrombophilia in proper perspective, it is essential to discuss two basic issues, i.e., the pathogenesis of NA-AION and whether thrombophilia has any role in that or not.

Pathogenesis of NA-AION

One often hears and reads that the pathogenesis of NA-AION is unknown, but that is no longer true with our current knowledge of the subject. The pathogenesis of NA-AION is discussed at length elsewhere [4]. NA-AION represents a multifactorial acute ischemic disorder of the optic nerve head (ONH) which is supplied by the posterior ciliary artery.

There is a widespread belief among ophthalmologists and neurologists that NA-AION has a pathogenesis similar to that of a stroke, i.e., both being thromboembolic disorders; however, the evidence does not support this view.
  1. 1.

    First and foremost, fluorescein fundus angiography soon after the onset of NA-AION shows only a delayed and slow filling of the peripapillary choroid and/or choroidal watershed zones, but no permanent occlusion [14], whereas a thromboembolic occlusive disorder (such as arteritic AION [14]) is always associated with complete occlusion of the posterior ciliary artery supplying the ONH.

     
  2. 2.

    The severity of ONH ischemic damage depends upon the severity and duration of the ONH ischemia, and that determines the extent of recovery of visual function following the acute episode. The following provides the important relevant information on this subject.

     
  3. A.

    Our studies have shown that in the vast majority of NA-AION patients, the main factor precipitating the development of NA-AION is transient nonperfusion or hypoperfusion of the ONH circulation during sleep in persons with other predisposing risk factors [4, 15]. This is supported by the following:

     
  4. (i)

    A study of 925 episodes of NA-AION showed that, in 73% of the episodes, the patients first discovered visual loss upon awakening or at first opportunity to use vision critically after sleeping [15]. This indicates that nocturnal arterial hypotension precipitated the development of NA-AION in persons with other risk factors; most of the other patients could not recollect definitely time when they first discovered the visual loss, suggesting that the visual loss development during sleep may be much higher than 73%.

     
  5. (ii)

    Twenty-four-hour ambulatory blood pressure monitoring showed not only a marked fall of blood pressure during sleep (Fig. 1) but also a significant relationship between progressive visual field deterioration and nocturnal arterial hypotension in NA-AION [16, 17].

     
  6. (iii)

    Among about 1,500 patients with NA-AION whom I have seen over the years, I have from time to time seen patients whose NA-AION was precipitated by the patient starting to take an arterial hypotensive medication in the evening or bedtime, producing abnormal nocturnal arterial hypotension [17]. There is evidence to suggest that the development of NA-AION following the use of erectile dysfunction drugs is primarily caused by fall of blood pressure in persons in the presence of other risk factors [18, 19].

     
Fig. 1

Ambulatory blood pressure monitoring records (based on individual readings) over a 24-hour period starting from about 11 a.m., in a 58-year old woman with bilateral NA-AION, and on no medication. The blood pressure is perfectly normal during the waking hours but there is marked nocturnal arterial hypotension during sleep

A transient fall of blood pressure during sleep results in a fall of perfusion pressure (perfusion pressure = mean blood pressure minus intraocular pressure) in the ONH vessels, causing transient nonperfusion or hypoperfusion of those vessels. A fall in perfusion pressure in the capillaries of the ONH below the critical autoregulatory range level, in susceptible persons, results in ischemia of the ONH and development of NA-AION. The severity of ONH ischemia following transient nonperfusion or hypoperfusion may vary from mild to marked, depending upon the severity and the duration of the transient ischemia and other factors influencing the blood flow in the ONH [20].
  1. B.

    In NA-AION, because there is only transient nonperfusion or hypoperfusion in the ONH circulation, there is usually much less severe and less extensive ONH damage than in arteritic AION due to thrombotic occlusion of the posterior ciliary artery [21]. Two large studies [22, 23] have shown that 41% of NA-AION eyes show spontaneous visual acuity improvement. In sharp contrast to that, no such visual improvement is seen in arteritic AION (a thrombotic disorder) [24].

     

Thus, the available evidence indicates that NA-AION is usually NOT a thromboembolic disorder but is due to a transient fall of perfusion pressure in the ONH vessels during nocturnal arterial hypotension, which results in transient nonperfusion or hypoperfusion of those vessels.

Further proof that NA-AION, unlike stroke, is not a thromboembolic disorder is provided by the following:
  1. (i).

    While there is a significant association between smoking and cerebrovascular accident (a thromboembolic disorder) [25], no such association has been found between smoking and NA-AION [1, 26].

     
  2. (ii).

    While the beneficial effect of aspirin in cerebrovascular accident (a thromboembolic disorder) is well-established, studies have shown that aspirin has no beneficial effects in NA-AION (being a hypotensive disorder) [26, 27, 28].

     

There is highly prevalent misconception in the ophthalmic community that a small or absent cup is actually the primary factor in the development of NA-AION; this has resulted in catchy terms like “disc at risk”. The role of an absent or small cup in the pathogenesis of development of NA-AION is discussed in detail elsewhere [29, 30]. Briefly, in the multifactorial scenario of the pathogenesis of NA-AION, an absent or small cup is simply a secondary contributing factor, ONCE the process of NA-AION has started, and NOT a primary factor [29, 30].

Thus the pathogenesis of NA-AION is complex but not, as often stated, unknown.

Thrombophilia

Thrombophilia is an inherited or acquired predisposition to thrombosis [31]. To evaluate whether thrombophilia has any role in development of NA-AION, one has to consider the following facts.
  1. 1.

    Thrombophilic factors cause circulatory disorders by causing thrombosis. However, as discussed about, NA-AION in the vast majority is NOT a thrombotic disorder.

     
  2. 2.

    The principal clinical manifestation of thrombophilia is venous thromboembolism [31]. NA-AION is not a venous thrombotic disorder but an arterial ischemic disorder.

     
  3. 3.

    As discussed above, aspirin, which is effective in treating thromboembolic disorders, has been shown to have no protective effect in NA-AION [26, 27, 28].

     
  4. 4.

    There are studies that have shown no association between NA-AION and thrombophilic risk factors. For example, Salomon et al. [32] in 61 patients with NA-AION found no association with Protein C, protein S, antithrombin III, lupus anticoagulant, and three prothrombotic polymorphisms (i.e., factor V G1691A, factor II G20210A, and methylenetetrahydrofolate reductase [MTHFR] C677T). Similarly, Biousse et al. [33] in 14 patients with NA-AION found homocysteine within normal limits in all of them, and mutation positive and mutation negative patients for MTHFR C677T did not differ with respect to clinical data concerning risk factors for NA-AION. Both studies concluded that there was no association between NA-AION and thrombophilic risk factors.

     

If testing of NA-AION patients reveals the presence of one or more abnormal thrombophilic factors that does not automatically imply a cause-and-effect relationship. That may be purely a coincidental finding and may explain some of the reported positive findings.

Thus, in the light of the above facts, there is little evidence that thrombophilia plays a role in development of NA-AION in the vast majority of cases. Of course, the possibility that thrombophilia may be involved in a rare case cannot be ruled out—in medicine there is no such thing as “never”. That raises the important question whether all patients with NA-AION should be tested for thrombophilia, as advocated by some [13]. According to Heit [31], “Currently, there is no single laboratory assay or simple set of assays that will identify all thrombophilias. Consequently, a battery of complex and potentially expensive assays is usually required. Many of these laboratory analyses are affected by other conditions (e.g., warfarin reduces protein C and S levels) such that the correct interpretation of the results can be complicated and always requires clinical correlation.” Leiden mutation of the factor V gene is associated with a procoagulant state, especially in the venous bed, and its association with arterial thrombotic disease remains unclear. Thus, testing patients with NA-AION for thrombophilia is unwarranted, unless there is a medical or family history of thrombosis.

Among the various studies on thrombophilia in NA-AION claiming an association between NA-AION and thrombophilia, there is not only conflicting and contradictory information but also there are other problems. Following are some examples:
  1. 1.

    The study by Giambene et al. [13], published in this issue, reported plasma levels of homocysteine and lipoprotein(a) significantly higher in patients with NA-AION compared with controls, with no significant difference in MTHFR C677T polymorphism between the two groups. They found arterial hypertension and dyslipidemia significantly more prevalent in patients than in controls, but that was not the case with diabetes mellitus and smoking. Their findings that there was no difference in prevalence of diabetes between the control and NA-AION groups in their study conflicts with the well-established fact that diabetes is significantly more common in NA-AION than controls [3, 5, 6]. This fact indicates a serious problem with the type of patients in the study and indirectly, the validity of their other findings. The authors also state that they did not register nutritional habits of their patients—which would be important to determine the role of diet on vitamin B6 and homocysteine circulating values. Nor did they measure homocysteine post-methionine plasma levels, which could be useful to reveal an impairment of homocysteine metabolism in a number of subjects. Their findings of significantly higher homocysteine in patients with NA-AION compared with controls is contradicted by the study by Biousse et al. [33], who found no such difference. Thus, one has to interpret the claims of Giambene et al. [13] in the light of these limitations, with caution.

     
  2. 2.

    Misleading information can be the result of several other factors. When diseases that look superficially very similar occur in different organs, there is a strong tendency to assume that the diseases pathogenesis and management are the same in the different organs. This is how the pathogenesis and management of stroke has been extrapolated to NA-AION. This represents a serious error of judgment. Similarly, the pathogenesis and management of central retinal vein occlusion and deep vein thrombosis are usually considered similar, although they have nothing in common morphologically, pathologically or clinically except for the thrombus. Also, some studies have lumped together all kinds of ocular vascular occlusive diseases in their thrombophilic evaluations, as if they were pathogenetically all one clinical entity. For example, Pianka et al. [8] and Stanger et al. [34] combined NA-AION with retinal vascular occlusions in their study on thrombophilia, which is unwarranted because that comprises at least five distinct ocular vascular disorder, with very different pathogeneses and other basic aspects.

     

These and other similar issues result in not only misleading information but also controversy on the pathogenesis and management of various diseases.

Studies have shown that severe hyperhomocysteinemia is a risk factor for development of atherosclerosis [35] and arteriosclerosis [36]. As discussed above, NA-AION is a disease of the middle-aged and elderly, a population in which there is a high incidence of atherosclerosis, arteriosclerosis, hyperlipidemia, diabetes mellitus, and other cardiovascular and other systemic diseases [3, 4]. Thus, finding of hyperhomocysteinemia in some NA-AION patients may simply be a manifestation of those vascular disorders and not in any way related to NA-AION.

Conclusions

In the light of all the available evidence, there is no scientifically rational basis for believing that thrombophilia has any role to play in NA-AION. Thus, testing patients with NA-AION for thrombophilia is unwarranted, unless there is a definite medical or family history of thrombosis.

Notes

Acknowledgements

I am grateful to Mrs. Patricia Duffel for her invaluable help with bibliography, and to my wife, Shelagh, for her help with this manuscript.

References

  1. 1.
    Hayreh SS, Jonas JB, Zimmerman MB (2007) Nonarteritic anterior ischemic optic neuropathy and tobacco smoking. Ophthalmology 114:804–809. doi: 10.1016/j.ophtha.2006.07.062 PubMedCrossRefGoogle Scholar
  2. 2.
    Preechawat P, Bruce BB, Newman NJ, Biousse V (2007) Anterior ischemic optic neuropathy in patients younger than 50 years. Am J Ophthalmol 144:953–960. doi: 10.1016/j.ajo.2007.07.031 PubMedCrossRefGoogle Scholar
  3. 3.
    Hayreh SS, Joos KM, Podhajsky PA, Long CR (1994) Systemic diseases associated with nonarteritic anterior ischemic optic neuropathy. Am J Ophthalmol 118:766–780PubMedGoogle Scholar
  4. 4.
    Hayreh SS (1996) Acute ischemic disorders of the optic nerve: pathogenesis, clinical manifestations, and management. Ophthalmol Clin North Am 9:407–442Google Scholar
  5. 5.
    Jacobson DM, Vierkant RA, Belongia EA (1997) Nonarteritic anterior ischemic optic neuropathy. A case-control study of potential risk factors. Arch Ophthalmol 115:1403–1407PubMedGoogle Scholar
  6. 6.
    Hayreh SS, Zimmerman MB (2008) Nonarteritic anterior ischemic optic neuropathy: clinical characteristics in diabetic patients versus nondiabetic patients. Ophthalmology 115:1818–1825 doi: 10.1016/j.ophtha.2007.05.027 PubMedCrossRefGoogle Scholar
  7. 7.
    Kawasaki A, Purvin VA, Burgett RA (1999) Hyperhomocysteinaemia in young patients with non-arteritic anterior ischaemic optic neuropathy. Br J Ophthalmol 83:1287–1290PubMedCrossRefGoogle Scholar
  8. 8.
    Pianka P, Almog Y, Man O, Goldstein M, Sela BA, Loewenstein A (2000) Hyperhomocystinemia in patients with nonarteritic anterior ischemic optic neuropathy, central retinal artery occlusion, and central retinal vein occlusion. Ophthalmology 107:1588–1592 doi: 10.1016/S0161-6420(00)00181-0 PubMedCrossRefGoogle Scholar
  9. 9.
    Weger M, Stanger O, Deutschmann H, Simon M, Renner W, Schmut O, Semmelrock J, Haas A (2001) Hyperhomocyst(e)inaemia, but not MTHFR C677T mutation, as a risk factor for non-arteritic ischaemic optic neuropathy. Br J Ophthalmol 85:803–806. doi: 10.1136/bjo.85.7.803 PubMedCrossRefGoogle Scholar
  10. 10.
    Nagy V, Facsko A, Takacs L, Balazs E, Berta A, Balogh I, Edes I, Czuriga I, Pfliegler G (2004) Activated protein C resistance in anterior ischaemic optic neuropathy. Acta Ophthalmol Scand 82:140–143. doi: 10.1111/j.1600-0420.2004.00226.x PubMedCrossRefGoogle Scholar
  11. 11.
    Glueck CJ, Wang P, Bell H, Rangaraj V, Goldenberg N (2004) Nonarteritic anterior ischemic optic neuropathy: associations with homozygosity for the C677T methylenetetrahydrofolate reductase mutation. J Lab Clin Med 143:184–192. doi: 10.1016/j.lab.2003.10.015 PubMedCrossRefGoogle Scholar
  12. 12.
    Nagy V, Steiber Z, Takacs L, Vereb G, Berta A, Bereczky Z, Pfliegler G (2006) Thrombophilic screening for nonarteritic anterior ischemic optic neuropathy. Graefes Arch Clin Exp Ophthalmol 244:3–8 doi: 10.1007/s00417-005-1154-5 PubMedCrossRefGoogle Scholar
  13. 13.
    Giambene B, Sodi A, Sofi F, Marcucci R, Fedi S, Abbate R, Prisco D, Menchin U (2008) Evaluation of traditional and emerging cardiovascular risk factors in patients with non arteritic anterior ischaemic optic neuropathy: a case-control study. Graefes Arch Clin Exp Ophthalmol (in press)Google Scholar
  14. 14.
    Hayreh SS (1985) Inter-individual variation in blood supply of the optic nerve head. Its importance in various ischemic disorders of the optic nerve head, and glaucoma, low-tension glaucoma and allied disorders. Doc Ophthalmol 59:217–246. doi: 10.1007/BF00159262 PubMedCrossRefGoogle Scholar
  15. 15.
    Hayreh SS, Podhajsky PA, Zimmerman B (1997) Nonarteritic anterior ischemic optic neuropathy: time of onset of visual loss. Am J Ophthalmol 124:641–647PubMedGoogle Scholar
  16. 16.
    Hayreh SS, Zimmerman MB, Podhajsky P, Alward WL (1994) Nocturnal arterial hypotension and its role in optic nerve head and ocular ischemic disorders. Am J Ophthalmol 117:603–624PubMedGoogle Scholar
  17. 17.
    Hayreh SS, Podhajsky P, Zimmerman MB (1999) Role of nocturnal arterial hypotension in optic nerve head ischemic disorders. Ophthalmologica 213:76–96 doi: 10.1159/000027399 PubMedCrossRefGoogle Scholar
  18. 18.
    Hayreh SS (2005) Erectile dysfunction drugs and non-arteritic anterior ischemic optic neuropathy: is there a cause and effect relationship? J Neuroophthalmol 25:295–298. doi: 10.1097/01.wno.0000189059.90057.98 PubMedGoogle Scholar
  19. 19.
    Hayreh SS (2008) Non-arteritic anterior ischemic optic neuropathy and phosphodiesterase-5 inhibitors. Br J Ophthalmol (in press)Google Scholar
  20. 20.
    Hayreh SS (2001) Blood flow in the optic nerve head and factors that may influence it. Prog Retin Eye Res 20:595–624. doi: 10.1016/S1350-9462(01)00005-2 PubMedCrossRefGoogle Scholar
  21. 21.
    Hayreh SS, Podhajsky PA, Zimmerman B (1998) Ocular manifestations of giant cell arteritis. Am J Ophthalmol 125:509–520. doi: 10.1016/S0002-9394(99)80192-5 PubMedCrossRefGoogle Scholar
  22. 22.
    Ischemic Optic Neuropathy Decompression Trial Research Group (1995) Optic nerve decompression surgery for nonarteritic anterior ischemic optic neuropathy (NAION) is not effective and may be harmful. JAMA 273:625–632 doi: 10.1001/jama.273.8.625 CrossRefGoogle Scholar
  23. 23.
    Hayreh SS, Zimmerman MB (2008) Nonarteritic anterior ischemic optic neuropathy: natural history of visual outcome. Ophthalmology 115:298–305. doi: 10.1016/j.ophtha.2007.05.027 PubMedCrossRefGoogle Scholar
  24. 24.
    Hayreh SS, Zimmerman B (2003) Visual deterioration in giant cell arteritis patients while on high doses of corticosteroid therapy. Ophthalmology 110:1204–1215. doi: 10.1016/S0161-6420(03)00228-8 PubMedCrossRefGoogle Scholar
  25. 25.
    Dagenais GR, Yi Q, Lonn E, Sleight P, Ostergren J, Yusuf S, HOPE Trial Investigators (2005) Impact of cigarette smoking in high-risk patients participating in a clinical trial. A substudy from the Heart Outcomes Prevention Evaluation (HOPE) trial. Eur J Cardiovasc Prev Rehabil 12:75–81. doi: 10.1097/00149831-200502000-00012 PubMedCrossRefGoogle Scholar
  26. 26.
    Newman NJ, Scherer R, Langenberg P, Kelman S, Feldon S, Kaufman D, Dickersin K (2002) The fellow eye in NAION: report from the ischemic optic neuropathy decompression trial follow-up study. Am J Ophthalmol 134:317–328. doi: 10.1016/S0002-9394(02)01639-2 PubMedCrossRefGoogle Scholar
  27. 27.
    Beck RW, Hayreh SS, Podhajsky PA, Tan ES, Moke PS (1997) Aspirin therapy in nonarteritic anterior ischemic optic neuropathy. Am J Ophthalmol 123:212–217PubMedGoogle Scholar
  28. 28.
    Botelho PJ, Johnson LN, Arnold AC (1996) The effect of aspirin on the visual outcome of nonarteritic anterior ischemic optic neuropathy. Am J Ophthalmol 121:450–451PubMedGoogle Scholar
  29. 29.
    Beck RW, Servais GE, Hayreh SS (1987) Anterior ischemic optic neuropathy. IX. Cup-to-disc ratio and its role in pathogenesis. Ophthalmology 94:1503–1508PubMedGoogle Scholar
  30. 30.
    Hayreh SS, Zimmerman MB (2008) Nonarteritic anterior ischemic optic neuropathy: refractive error and its relationship to cup/disc ratio. Ophthalmology (in press)Google Scholar
  31. 31.
    Heit JA (2007) Thrombophilia: common questions on laboratory assessment and management. Hematology (Am Soc Hematol Educ Program) 2007:127–135. doi: 10.1182/asheducation-2007.1.127 Google Scholar
  32. 32.
    Salomon O, Huna-Baron R, Kurtz S, Steinberg DM, Moisseiev J, Rosenberg N, Yassur I, Vidne O, Zivelin A, Gitel S, Davidson J, Ravid B, Seligsohn U (1999) Analysis of prothrombotic and vascular risk factors in patients with nonarteritic anterior ischemic optic neuropathy. Ophthalmology 106:739–742. doi: 10.1016/S0161-6420(99)90159-8 PubMedCrossRefGoogle Scholar
  33. 33.
    Biousse V, Kerrison JB, Newman NJ (2000) Is non-arteritic anterior ischaemic optic neuropathy related to homocysteine? Br J Ophthalmol 84:555 doi: 10.1136/bjo.84.5.554c PubMedCrossRefGoogle Scholar
  34. 34.
    Stanger O, Weger M, Obeid R, Temmel W, Meinitzer A, Steinbrugger I, Schmut O, Herrmann W (2005) Impairment of homocysteine metabolism in patients with retinal vascular occlusion and non-arteritic ischemic optic neuropathy. Clin Chem Lab Med 43:1020–1025. doi: 10.1515/CCLM.2005.179 PubMedCrossRefGoogle Scholar
  35. 35.
    Eldibany MM, Caprini JA (2007) Hyperhomocysteinemia and thrombosis: an overview. Arch Pathol Lab Med 131:872–884PubMedGoogle Scholar
  36. 36.
    McCully KS (2005) Hyperhomocysteinemia and arteriosclerosis: historical perspectives. Clin Chem Lab Med 43:980–986. doi: 10.1515/CCLM.2005.172 PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  1. 1.Department of Ophthalmology and Visual Sciences, College of MedicineUniversity of IowaIowa CityUSA
  2. 2.Department of Ophthalmology and Visual SciencesUniversity Hospitals & ClinicsIowa CityUSA

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