Evaluation of macular abnormalities in Stargardt’s disease using optical coherence tomography and scanning laser ophthalmoscope microperimetry
- 349 Downloads
The purpose of this study is to evaluate the diagnostic value of optical coherence tomography (Stratus OCT) and scanning laser ophthalmoscope (SLO) microperimetry in patients with Stargardt’s disease (STGD), and the correlation between macular morphology and visual function in these patients.
Twenty-two patients with STGD (mean age 44 years, range 11 to 71 years) and 20 age-matched healthy control subjects were included in the study. OCT imaging was performed using six radial line scans manually centered on the fovea. SLO microperimetry was used to assess central scotoma and fixation behavior in patients with STGD.
Mean best corrected Snellen visual acuity (BCVA) was 20/80, range 20/25 to 20/300 (log MAR 0.6, range 0.1 to 1.2) in the STGD group and 20/20 (log MAR 0.0) in the control group. Foveal thickness was significantly reduced in patients with STGD (119.0 ± 19.6 μm) compared to controls (210.7 ± 19.6 μm, P < 0.0001). A significant correlation between foveal thickness and BCVA was observed within the STGD group (R2 = 0.62, P < 0.0001). Photoreceptor loss in the macular area and a corresponding central scotoma were observed in all STGD patients.
OCT findings, particularly reduced foveomacular thickness and photoreceptor loss in the macular area may be useful in the diagnosis of STGD. Furthermore, a strong correlation between foveal thickness and visual function was observed in our patients. Assessment of central visual function using SLO microperimetry provides additional useful information, important in the management of STGD.
KeywordsStargardt’s disease Optical coherence tomography Scanning laser ophthalmoscope microperimetry
- 4.Berisha F, Hovland PG, Feke GT, Arroyo JG, Bertram K, Hirose T (2006) Preoperative OCT evaluation of photoreceptor defects is a prognostic indicator of visual acuity outcome in macular hole surgery. Program and abstracts of the AAO/APAO Joint Meeting; Las Vegas, Nevada. Poster number 737Google Scholar
- 7.Edwards AO, Miedziak A, Vrabec T, Verhoeven J, Acott TS, Weleber RG et al (1999) Autosomal dominant Stargardt-like macular dystrophy: I. Clinical characterization, longitudinal follow-up, and evidence for a common ancestry in families linked to chromosome 6q14. Am J Ophthalmol 127:426–435. doi: 10.1016/S0002-9394(98)00331-6 PubMedCrossRefGoogle Scholar
- 8.Ergun E, Hermann B, Wirtitsch M, Unterhuber A, Ko TH, Sattmann H et al (2005) Assessment of central visual function in Stargardt’s disease/fundus flavimaculatus with ultrahigh-resolution optical coherence tomography. Invest Ophthalmol Vis Sci 46:310–316. doi: 10.1167/iovs.04-0212 PubMedCrossRefGoogle Scholar
- 11.Franceschetti A (1963) Über tapetoretinale Degenerationen im Kindesalter. In: Sauter H (ed) Entwicklung und Fortschritt in der Augenheilkunde. Enke, Stuttgart, Germany, pp 107–120Google Scholar
- 12.Franceschetti A, Francois J (1965) Fundus flavimaculatus. Arch Ophtalmol (Paris) 25:505–530Google Scholar
- 19.Kanski JJ (2007) Clinical Ophthalmology: a systematic approach, 6th edn, Chapter 18. Fundus Dystrophies, pp 670–672Google Scholar