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Efficacy and safety of heavy silicone oil Densiron 68® in the treatment of complicated retinal detachment with large inferior retinectomy

  • Sylvain Auriol
  • Véronique Pagot-Mathis
  • Laurence Mahieu
  • Claudia Lemoine
  • André MathisEmail author
Retinal Disorders

Abstract

Purpose

To assess the efficacy and safety of a heavy silicone oil (Densiron 68®), a mixture of perfluorohexyloctane (F6H8) with silicone oil as temporary internal tamponade in selected retinal detachments treated with large inferior retinectomy.

Methods

Complicated retinal detachments with severe posterior and anterior proliferative vitreoretinopathy (PVR) were included in this study. In all cases, a large inferior retinectomy involving the inferior quadrants was performed. Densiron 68® was injected at the end of surgery after perfluorocarbon injection. A minimum follow-up of 6 months was required in order to be included in this retrospective study.

Results

Twenty-seven patients were operated on with a mean follow-up of 57.5 weeks. Twenty-three patients presented a posterior PVR > CP6 and 26 patients an anterior PVR > CA5. Heavy silicone oil was removed in 19 patients after a mean follow-up of 14 weeks. At the 4-week follow-up visit, only one retinectomy was reopened by a recurrent inferior retinal detachment with PVR CP3. Finally, anatomical success was achieved in 25 of the 27 patients (92.5%) after Densiron 68® removal at the last follow-up. The main adverse effect was inflammatory reaction with fibrin accumulation in the anterior chamber (40.7%).

Conclusion

Densiron 68® appeared to be an efficient endotamponade agent in selected retinal detachments treated with large inferior retinectomy. It avoids fluid accumulation under the inferior retina and seems to limit the rate of inferior retinectomy reopening.

Keywords

Heavy silicone oil Ocular endotamponade Perfluorohexyloctane Proliferative vitreoretinopathy Retinal detachment Retinectomy 

References

  1. 1.
    Abrams GW, Azen SP, McCuen BW II, Flynn HW Jr, Lai MY, Ryan SJ (1997) Vitrectomy with silicone oil or long-acting gas in eyes with severe proliferative vitreoretinopathy: results of additional and long-term follow-up. Silicone study report 11. Arch Ophthalmol 115:335–344PubMedGoogle Scholar
  2. 2.
    Azen SP, Scott IU, Flynn HW Jr, Lai MY, Topping TM, Benati L, Trask DK, Rogus LA (1998) Silicone oil in the repair of complex retinal detachments. A prospective observation multicenter study. Ophthalmology 105:1587–1597PubMedCrossRefGoogle Scholar
  3. 3.
    Cammacho H, Bajaire B, Mejia LF (1992) Silicone oil in the management of giant retinal tears. Ann Ophthalmol 24:45–49CrossRefGoogle Scholar
  4. 4.
    Capone A Jr, Aasberg TM (1995) Silicone oil in vitreoretinal surgery. Curr Opin Ophthalmol 6:33–37PubMedGoogle Scholar
  5. 5.
    Cibis A, Becker B, Okun E, Canaan S (1962) The use of liquid silicone oil in retinal detachment surgery. Arch Ophthalmol 68:46–55Google Scholar
  6. 6.
    Cox MS, Trese MT, Murphy PL (1986) Silicone oil for advanced proliferative vitreoretinopathy. Ophthalmology 93:646–650PubMedGoogle Scholar
  7. 7.
    Faude F, Lambert A, Wiedemann P (1998) 360 degrees retinectomy in severe anterior PVR and PDR. Int Ophthalmol. 22:119–123PubMedCrossRefGoogle Scholar
  8. 8.
    Gonvers M (1983) Temporary use of silicone oil in the treatment of special cases of retinal detachment. Ophthalmologica 187:202–209PubMedCrossRefGoogle Scholar
  9. 9.
    Herbrig E, Sandner D, Engelmann K (2007) Anatomical results of endotemponade with heavy silicone oil – Densiron 68 – in complicated retinal detachment. Ophthalmic Res 39:198–206PubMedCrossRefGoogle Scholar
  10. 10.
    Jonas JB, Budde WM, Knorr HL (1999) Timing of retinal redetachment after removal of intraocular silicone oil tamponade. Am J Ophthalmol 128:628–631PubMedCrossRefGoogle Scholar
  11. 11.
    Kampik A, Hoing C, Heidenkummer HP (1992) Problems and timing in the removal of silicone oil. Retina 12:S11–S16PubMedCrossRefGoogle Scholar
  12. 12.
    Lucke KH, Foerster MH, Laqua H (1987) Long-term results of vitrectomy and silicone oil in 500 cases of complicated retinal detachments. Am J Ophthalmol 104:624–633PubMedGoogle Scholar
  13. 13.
    Machemer R, Aaberg TM, Freeman HM, Irvine AR, Lean JS, Michels RM (1991) An updated classification of retinal detachment with proliferative vitreoretinopathy. Am J Ophthalmol 112:159–165PubMedGoogle Scholar
  14. 14.
    McCuen BW, de Juan E Jr, Landers MB, Machemer R (1985) Silicone oil in vitreoretinal surgery. Part 2: results and complications. Retina 5:198–205PubMedCrossRefGoogle Scholar
  15. 15.
    McCuen BW, de Juan E Jr, Machemer R (1985) Silicone oil in vitreoretinal surgery. Part 1: surgical techniques. Retina 5:189–197PubMedCrossRefGoogle Scholar
  16. 16.
    McCuen BW, Landers MB, Machemer R (1985) The use of silicone oil following failed vitrectomy for retinal detachment. Ophthalmology 92:1029–1034PubMedGoogle Scholar
  17. 17.
    Morse LS, McCuen BW 2nd, Machemer R (1990) Relaxing retinotomies. Analysis of anatomical and visual results. Ophthalmology 97:642–647, discussion 647–648PubMedGoogle Scholar
  18. 18.
    Pagot-Mathis V, Benouaich X, Mathis A, Rico-Lates I, Dumoulin A (2006) Tamponnement interne par huile de silicone lourde (Oxane Hd®) dans les décollements de rétine complexes. J Fr Ophtalmol 29:137–145PubMedCrossRefGoogle Scholar
  19. 19.
    Riedel KG, Gabel VP, Neubauer L, Kampik A, Lund OE (1990) Intravitreal silicone oil injection: complications and treatment of 415 consecutive patients. Graefes Arch Clin Exp Ophthalmol 228:19–23PubMedCrossRefGoogle Scholar
  20. 20.
    Rizzo S, Belting C, Genovesi-Ebert F, Cresti F, Vento A, Martini R (2006) Successful treatment of persistent macular holes using “heavy silicone oil” as intraocular tamponade. Retina 26:905–908PubMedCrossRefGoogle Scholar
  21. 21.
    Sandner D, Engelmann K (2006) First experiences with high-density silicone oil (Densiron) as intraocular tamponade in complex retinal detachment. Graefe’s Arch Clin Exp Ophthalmol 244:609–619CrossRefGoogle Scholar
  22. 22.
    Sandner D, Herbrig E, Engelmann K (2007) High-silicone oil (Densiron) as a primary intraocular tamponade: 12-month follow-up. Graefe Arch Clin Exp Ophthalmol 245:1097–105CrossRefGoogle Scholar
  23. 23.
    Scholda C, Egger S, Lakits A, Haddad R (1997) Silicone oil removal: results, risks and complications. Acta Ophthalmol Scand 75:695–699PubMedCrossRefGoogle Scholar
  24. 24.
    Scholda C, Egger S, Lakits A, Walch K, von Eclarstein E, Biowski R (2000) Retinal detachment after silicone oil removal. Acta Ophthalmol Scand 78:182–186PubMedCrossRefGoogle Scholar
  25. 25.
    Sell CH, McCuen BWD, Landers MBD, Machemer R (1987) Long-term results of successful vitrectomy with silicone oil for advanced proliferative vitreoretinopathy. Am J Ophthalmol 103:24–28PubMedGoogle Scholar
  26. 26.
    Theelen T, Tilanus M, Klevering BJ (2004) Intraocular inflammation following endotamponade with high-density silicone oil. Graefes Arch Clin Exp Ophthalmol 242:617–620PubMedCrossRefGoogle Scholar
  27. 27.
    Van Meurs JC, Mertens DA, Perperkamp E, Post J (1993) Five-year results of vitrectomy and silicone oil in patients with proliferative vitreoretinopathy. Retina 13:285–289PubMedCrossRefGoogle Scholar
  28. 28.
    Wiedemann P, Hilgers RD, Bauer P, Heimann K (1998) Adjunctive daunorubicin in the treatment of proliferative vitreoretinopathy: results of a multicenter clinical trial. Daunomycin Study Group. Am J Ophthalmol 126:550–559PubMedCrossRefGoogle Scholar
  29. 29.
    Wolf S, Verena Schon PhD, Meier P, Wiedemann P (2003) Silicone oil-RMN3 mixture (« Heavy silicone oil ») as internal tamponade for complicated retinal detachment. Retina 23:335–342PubMedCrossRefGoogle Scholar
  30. 30.
    Wong D, Van Meurs JC, Stappler T, Groenewald C, Pearce IA, McGalliard JN, Manousakis E, Herbert EN (2005) A pilot study on the use of a perfluorohexyloctane/silicone oil solution as a heavier than water internal tamponade. Br J Ophthalmol 89:662–665PubMedCrossRefGoogle Scholar
  31. 31.
    Yeo JH, Glaser BM, Michels RG (1987) Silicone oil in the treatment of complicated retinal detachments. Ophthalmology 94:1109–1113PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Sylvain Auriol
    • 1
  • Véronique Pagot-Mathis
    • 1
  • Laurence Mahieu
    • 1
  • Claudia Lemoine
    • 1
  • André Mathis
    • 1
    • 2
    Email author
  1. 1.Department of OphthalmologyHopital RangueilToulouse Cedex 9France
  2. 2.Hopital Rangueil, Service d’OphtalmologieCedex 9France

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