Combination of laser photocoagulation and intravitreal bevacizumab (Avastin®) for aggressive zone I retinopathy of prematurity

  • Eun Jee Chung
  • Ji Hyun Kim
  • Hyun Seok Ahn
  • Hyoung Jun Koh
Case Report



This report describes the use of combined laser photocoagulation and intravitreal bevacizumab administration for aggressive zone I retinopathy of prematurity (ROP).


A male patient, born at 25 weeks gestation with a birth weight of 884 g, received indirect laser photocoagulation and a 0.75 mg intravitreal bevacizumab injection to each eye for aggressive stage 3 zone I ROP. Structural outcomes were evaluated 3 months after treatment.


At 3-month follow-up, treatment had resulted in ROP regression, prompt resolution of plus signs and neovascular proliferation in both eyes, and no signs of systemic or ocular adverse events.


The combination of indirect laser photocoagulation and intravitreal bevacizumab injection was well tolerated and induced prompt regression of aggressive zone I ROP.


Retinopathy of prematurity Indirect laser photocoagulation Intravitreal bevacizumab injection 


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Eun Jee Chung
    • 1
  • Ji Hyun Kim
    • 1
  • Hyun Seok Ahn
    • 1
  • Hyoung Jun Koh
    • 1
    • 2
  1. 1.The Institute of Vision ResearchDepartment of Ophthalmology,Yonsei University College of MedicineSeoulSouth Korea
  2. 2.Department of OphthalmologyYonsei University College of MedicineSeoulSouth Korea

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