Intravitreal dexamethasone as adjuvant in the treatment of postoperative endophthalmitis: a prospective randomized trial

  • Ivan M. Gan
  • Luana C. Ugahary
  • Jaap T. van Dissel
  • Eric Feron
  • Ed Peperkamp
  • Marc Veckeneer
  • Paul G. H. Mulder
  • Gert Jan Platenkamp
  • Jan C. van Meurs
Clinical Investigation

Abstract

Purpose

To study whether intravitreal dexamethasone as adjuvant to intravitreal antibiotics improves the outcome in patients with suspected postoperative bacterial endophthalmitis.

Design

Prospective randomized clinical trial.

Setting

Tertiary referral center.

Patient population

Twenty-nine consecutive patients with suspected postoperative bacterial endophthalmitis within 6 weeks of cataract surgery.

Intervention

Patients underwent a vitreous biopsy followed by intravitreal injection of antibiotics (0.2 mg vancomycin and 0.05 mg gentamicin) and 400 μg dexamethasone or placebo. After 3–4 days the intravitreal injection of antibiotics and dexamethasone or placebo was repeated

Primary outcome measure

Snellen visual acuity at 3 and 12 months after treatment.

Results

In 20/29 patients (69%) the vitreous cultures were positive. 13/29 patients received dexamethasone. Seven patients had a functionally lost eye (final vision of hand movements or less), in four due to retinal detachment. Visual acuity tended to be better in the dexamethasone treated patients than in those given placebo, at both 3 months (P=0.055) and 12 months (P=0.080).

Conclusion

This small prospective, placebo-controlled series showed a trend towards a better visual outcome in patients with suspected bacterial endophthalmitis when treatment with intravitreal antibiotics was combined with intravitreal dexamethasone. Our findings justify a larger multicenter randomized study.

Keywords

Endophthalmitis Dexamethasone Adjuvant 

Notes

Acknowledgements

We gratefully acknowledge the help of Diane A.E. Mertens, Peter J. Ringens, vitreoretinal surgeons and Jan Jansen, Westblaak Pharmacy, Rotterdam.

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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Ivan M. Gan
    • 1
  • Luana C. Ugahary
    • 1
  • Jaap T. van Dissel
    • 2
  • Eric Feron
    • 1
  • Ed Peperkamp
    • 1
  • Marc Veckeneer
    • 1
  • Paul G. H. Mulder
    • 3
  • Gert Jan Platenkamp
    • 4
  • Jan C. van Meurs
    • 1
  1. 1.The Rotterdam Eye HospitalRotterdamThe Netherlands
  2. 2.Department of Infectious DiseasesUniversity of Leiden Medical CenterLeidenThe Netherlands
  3. 3.Department of Epidemiology & BiostatisticsErasmus University Medical Center RotterdamRotterdamThe Netherlands
  4. 4.Regional Medical Microbiological LaboratoryRotterdamThe Netherlands

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