Non-invasive polarimetric measurement of glucose concentration in the anterior chamber of the eye
Diabetes mellitus is one of the most common diseases in industrialized countries as well as in emerging economies such as India or China. One of the key technologies for diabetes therapy is semi-continuous monitoring of the glucose level of diabetics.
Compared with skin-perforating techniques, optical measurement techniques promising good results bear the potential for high patient compliance with more frequent measurements. Due to its excellent optical properties, the anterior chamber and the aqueous humor (AH) contained therein offer promise for non-invasive in vivo glucose measurements. However, a number of strongly limiting factors, such as the precise optical properties of the eye, laser safety regulations and subconscious eye movements during the measurement period have to be considered for in vivo applications.
This article presents a high-resolution polarimetric measurement system that utilizes the optical rotatory dispersion (optical activity) of the glucose molecule for measurements of the glucose concentration in AH.
Based on this example of a suitable optical measurement system, the special limitations and conditions that have to be considered for in vivo glucose measurement at the human eye are presented and analyzed. This includes the optical properties of the cornea and the anterior chamber, the impact of typical eye movements during a measurement and laser safety regulations.
- 2.Baba J, Meledeo A, Cameron BD, Coté GL (2001) Investigation of pH and temperature on optical rotatory dispersion for noninvasive glucose monitoring. Proc SPIE 4263Google Scholar
- 3.Böckle S, Rovati L, Ansari RR (2002) Polarimetric glucose sensing using Brewster-reflection off of eye lens: theoretical analysis, optical diagnostics and sensing of biological fluids and glucose and cholesterol monitoring II. Proc SPIE 4624:160–164Google Scholar
- 4.Born M, Wolf E (1980) Principles of optics. Pergamon, New YorkGoogle Scholar
- 5.Cameron BD, Coté GL (2000) Optical polarimetry applied to the development of a noninvasive in-vivo glucose monitor. Proc SPIE BiOSGoogle Scholar
- 7.Center for Disease Control: http://www.cdc.gov/Diabetes/, National diabetics fact sheet
- 10.Diabetes Control and Complications Trial Research Group (1997) Lifetime benefits and costs of intensive therapy as practiced in the diabetes control and complications trial. Clin Diabetes 15:140–146Google Scholar
- 11.European safety laser regulations: EN/IEC 60825-1:1993 + A11:1996 + A2:2001 (November 2001)Google Scholar
- 12.Gullstrand A (1924) Helmholz’s physiological optics. Optical Society of America, App. pp 350–358Google Scholar
- 14.International Diabetes Foundation: http://www.idf.org/
- 15.Le Grand Y, El Hage SG (1980) Physiological optics. Springer Series in Optical Science. Springer, Berlin Heidelberg New YorkGoogle Scholar
- 16.McNichols RJ, Cameron BD, Coté GL (2001) Development of a non-invasive polarimetric glucose sensor, IEEE, LEOS NewsletterGoogle Scholar
- 17.Pierscionek BK (1994) Refractive index of the human lens surface measured with an optical fibre sensor. Ophthalmic Res 66:32–35Google Scholar
- 18.Pierscionek BK, Chan DYC (1998) Refractive index gradient of human lenses. Optom Vis Sci 66:822–829Google Scholar
- 19.Rawer R, Stork W et al (2002) Polarimetric methods for measurements of intra ocular glucose concentration. 36. Jahrestagung der Deutschen Gesellschaft für Biomedizinische Technik (DGBMT). Schiele Schön 47:186–187Google Scholar
- 20.Rawer R, Malz A, Vollmer P, Stork W (2003) Analysis of signal processing scheme for polarimetric in-vivo glucose measurement in aqueous humor. 37. Jahrestagung der Deutschen Gesellschaft für Biomedizinische Technik (DGBMT). Schiele Schön 48:430–431Google Scholar
- 21.Rysa P, Sarvaranta J (1974) Corneal temperature in man and rabit. Observations made using an infra-red camera and a cold chamber. Acta Ophthalmol Copenh Suppl 123:324–339Google Scholar
- 22.Schrader W (2000) Spektrometrie des Auges: Wege zur nichtinvasiven Diagnostik. Habilitationsschrift, Julius-Maximilians Universität WürzburgGoogle Scholar
- 23.World Health Organization (WHO) http://www.who.int/
- 24.Yu NT, Long JR, Price JF et al (1996) Development of a noninvasive diabetes screening device using the ratio of fluorescence to Rayleigh scattered light. J Biomed Opt 3:280–288Google Scholar