Optical energy transfer for intraocular microsystems studied in rabbits

  • Thomas LaubeEmail author
  • Claudia Brockmann
  • Rüdiger Buß
  • Carsten Lau
  • Kerstin Höck
  • Natalie Stawski
  • Thomas Stieglitz
  • Horst A. Richter
  • Harald Schilling
Laboratory Investigation



The development of a visual prosthesis aims to restore partial vision in patients with diseases which lead to total photoreceptor loss. The wireless power supply for a retinal implant may be realized with electromagnetic induction or with optical energy transfer. The present study investigates the feasibility of a photovoltaic power generation in the intraocular lens (IOL) part of an epiretinal implant for long-term tests in rabbits.


IOLs containing an array of photovoltaic cells (PVC) and a light-emitting diode (LED) were implanted into the capsular bag after phacoemulsification in three chinchilla rabbits. Optical energy transfer was established with an infrared laser beam at 850 nm wavelength. Lighting up of the LED proved the functioning of the PVC array. The maximum duration of in vivo functioning of the implant was determined by regular tests involving laser beam application. The explanted microsystems were technically analyzed. Tissues of both eyes underwent routine histological examinations.


The lifespan of the microsystems ranged from 14 days to more than 7 months. Final malfunction was caused by PVC defects or by defective contacts between PVC and LED that may originate from the low adhesive strength between the silicone cover and the underlying electronic components. The histological examination showed no alterations of the retinal structure in the treated eyes.


The power supply for intraocular microsystems by an array of photovoltaic cells was proven to be feasible in long-term tests in rabbits. An essential prerequisite for a future device is hermetic coating of the electronics.


Silicone Layer Microelectrode Array Corneal Edema Visual Prosthesis Infrared Laser Beam 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Financial support: BMBF grant to the EPI-RET research group, Germany


  1. 1.
    Birngruber R, Gabel VP (1983) Thermal versus photochemical damage in the retina—thermal calculations for exposure limits. Trans Ophthalmol Soc U K 103: 422–427PubMedGoogle Scholar
  2. 2.
    Chow AY, Chow VY (1997) Subretinal electrical stimulation of the rabbit retina. Neurosci Lett 225:13–16PubMedGoogle Scholar
  3. 3.
    Chow AY, Chow VY, Pardue MT, Perlman JI, Peachey NS (1998) Retinal and cortical potentials induced by subretinally implanted microphotodiode arrays. Invest Ophthalmol Vis Sci 39: S565Google Scholar
  4. 4.
    Eckmiller R (1997) Learning retina implants with epiretinal contacts. Ophthalmic Res 29:281–289PubMedGoogle Scholar
  5. 5.
    Hämmerle H, Kobuch K, Kohler K, Nisch W, Sachs H, Stelzle M (2002) Biostability of micro-photodiode arrays for subretinal implantation. Biomaterials 23:797–804CrossRefPubMedGoogle Scholar
  6. 6.
    Humayun MS, de Juan E, Jr., Dagnelie G, Greenberg RJ, Propst RH, Phillips DH (1996) Visual perception elicited by electrical stimulation of retina in blind humans. Arch Ophthalmol 114:40–46PubMedGoogle Scholar
  7. 7.
    Loeb GE, Bak MJ, Salcman M, Schmidt EM (1977) Parylene as a chronically stable, reproducible microelectrode insulator. IEEE Trans Biomed Eng 24:121–128PubMedGoogle Scholar
  8. 8.
    Margalit E, Maia M, Weiland JD, Greenberg RJ, Fujii GY, Torres G, Piyathaisere DV, O’Hearn TM, Liu W, Lazzi G, Dagnelie G, Scribner DA, de Juan E Jr, Humayun MS (2002) Retinal prosthesis for the blind. Surv Ophthalmol 47:335–356CrossRefPubMedGoogle Scholar
  9. 9.
    Moore K, Graham M, Barr M (1953) The detection of chromosomal sex in hermaphrodites from a skin biopsy. Surg Gynecol Obstet 96:641–648PubMedGoogle Scholar
  10. 10.
    Peachey NS, Chow AY (1999) Subretinal implantation of semiconductor-based photodiodes: progress and challenges. J Rehabil Res Dev 36:371–376PubMedGoogle Scholar
  11. 11.
    Rizzo JF, Wyatt JL (1997) Prospects for a visual prosthesis. Neuroscientist 3:251–262Google Scholar
  12. 12.
    Rizzo JF, Wyatt JL (1999) Retinal prosthesis. In: Maguire MG (ed) Age-related macular degeneration. Mosby, St. Louis, pp 413–432Google Scholar
  13. 13.
    Stieglitz T, Beutel H, Keller R, Blau C, Meyer J-U (1997) Development of flexible stimulation devices for a retina implant system. Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 30 Oct–2 Nov 1997, Chicago, pp 2307–2310Google Scholar
  14. 14.
    Stieglitz T, Beutel H, Schuettler M, Meyer JU (2000) Micromachined, polyimide-based devices for flexible neural interfaces. Biomedical Microdevices 2:283–294CrossRefGoogle Scholar
  15. 15.
    Stieglitz T, Keller R, Beutel H, Meyer J-U (2000) Microsystem integration techniques for intraocular vision prostheses using flexible polyimide-foils. Proceedings of MICRO.tec 2000, 25–27 September, Hannover, Germany, pp 467–472Google Scholar
  16. 16.
    Stieglitz T, Kammer S, Koch KP, Wien S, Robitzki A (2002) Encapsulation of flexible biomedical microdevices with Parylene C. Proceedings of the 7th Annual International Conference of the International Functional Electrical Stimulation Society, 25–29 June 2002, Ljubljana, Slowenia, pp 231–233Google Scholar
  17. 17.
    Walter P, Heimann K (2000) Evoked cortical potentials after electrical stimulation of the inner retina in rabbits. Graefes Arch Clin Exp Ophthalmol 238:315–318PubMedGoogle Scholar
  18. 18.
    Yuen TG, Agnew WF, Bullara LA (1987) Tissue response to potential neuroprosthetic materials implanted subdurally. Biomaterials 8:138–141CrossRefPubMedGoogle Scholar
  19. 19.
    Zrenner E (2002) Will retinal implants restore vision? Science 295:1022–1025PubMedGoogle Scholar
  20. 20.
    Zrenner E, Stett A, Weiss S, Aramant RB, Guenther E, Kohler K, Miliczek KD, Seiler MJ, Haemmerle H (1999) Can subretinal microphotodiodes successfully replace degenerated photoreceptors? Vision Res 39:2555–2567PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Thomas Laube
    • 1
    Email author
  • Claudia Brockmann
    • 1
  • Rüdiger Buß
    • 2
  • Carsten Lau
    • 3
  • Kerstin Höck
    • 1
  • Natalie Stawski
    • 2
  • Thomas Stieglitz
    • 4
  • Horst A. Richter
    • 3
  • Harald Schilling
    • 1
  1. 1.Department of OphthalmologyDuisburg-Essen UniversityEssenGermany
  2. 2.Optoelectronics Department, Center for Semiconductor Technology and OptoelectronicsDuisburg-Essen UniversityDuisburgGermany
  3. 3.Working Group on Biomaterials, Institute of PathologyAachen UniversityAachenGermany
  4. 4.Neural Prosthetics GroupFraunhofer Institute for Biomedical EngineeringSt. IngbertGermany

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