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Group IIA phospholipase A2 content of tears in patients with keratoconjunctivitis sicca

  • Valtteri V. Aho
  • Timo J. Nevalainen
  • Matti K. Saari
Clinical Investigation

Abstract

Purpose. To determine the concentration of group IIA phospholipase A2 (GIIAPLA2) in tears of patients with keratoconjunctivitis sicca (KCS) and to compare it with the GIIAPLA2 content of tears in age-matched healthy controls.

Methods. The GIIAPLA2 content of tears was measured with time-resolved fluoroimmunoassay in 20 patients with KCS (mean age 70.7±8.7 years) and in 20 normal subjects (mean age 70.2±9.9 years).

Results. The GIIAPLA2 content of tears in patients with KCS was 75.8±54.2 µg/ml and in normal subjects it was 34.2±21.4 µg/ml. The difference was statistically significant. In patients with KCS the GIIAPLA2 concentration slightly increased with decreasing Schirmer test values (Spearman's correlation =–0.20)

Conclusion. The results of this study indicate that in patients with KCS the relative concentration of GIIAPLA2 of tears was increased due to decreased aqueous production in the lacrimal glands and better preservation of the acinar cells in the central parts of the lobules of the lacrimal glands producing GIIAPLA2.

Keywords

Acinar Cell Lacrimal Gland Micrococcus Luteus Schirmer Test Senile Cataract 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • Valtteri V. Aho
    • 1
  • Timo J. Nevalainen
    • 2
  • Matti K. Saari
    • 1
  1. 1.Department of Ophthalmology, University of Turku, 20520 Turku, FinlandFinland
  2. 2.Department of Pathology, University of Turku, Turku, FinlandFinland

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