Journal of Neurology

, Volume 248, Issue 1, pp 45–50

Neuropsychological profiles of familial Alzheimer's disease associated with mutations in the presenilin 1 and amyloid precursor protein genes

  • E.K. Warrington
  • S.K. Agnew
  • A.M. Kennedy
  • M.N. Rossor
Original communication

DOI: 10.1007/s004150170268

Cite this article as:
Warrington, E., Agnew, S., Kennedy, A. et al. J Neurol (2001) 248: 45. doi:10.1007/s004150170268

Abstract

Patients with familial Alzheimer's disease and a subset known to have presenilin mutations were compared with sporadic cases on a comprehensive battery of cognitive tests. These included measures of memory, intelligence, language and perception. The three group were very comparable, in terms of severity, on global measures of dementia. However, their profiles/patterns of cognitive impairment differed in two respects; the group with sporadic Alzheimer's disease were significantly more impaired on tests of object naming and object perception than either the group with familial Alzheimer's disease or group with familial Alzheimer's disease and presenilin mutations, yet they scored at a significantly higher level on the measure of verbal intelligence. This study provides further evidence of the heterogeneity of the disease process.

Key words Neuropsychology Familial Alzheimer's disease 

Copyright information

© Steinkopff Verlag 2001

Authors and Affiliations

  • E.K. Warrington
    • 1
  • S.K. Agnew
    • 1
  • A.M. Kennedy
    • 1
  • M.N. Rossor
    • 1
  1. 1.Dementia Research Group, Department of Clinical Neurology, Institute of Neurology, Queen Square, London, WC1 3BG, UK, Tel.: +44-20-78 37 36 11, ext 36 39, Fax: +44-20-72 09 01 82GB

Personalised recommendations